NOTCH1 HD+PEST domain mutants bind DLL1

Stable Identifier
R-HSA-2900748
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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NOTCH1 in cis HD and PEST domain mutants are expected to bind DLL1 ligand, just like NOTCH1 HD mutants alone (Malecki et al. 2006).

Literature References
PubMed ID Title Journal Year
16738328 Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

Malecki, MJ, Sanchez-Irizarry, C, Mitchell, JL, Histen, G, Xu, ML, Aster, JC, Blacklow, SC

Mol. Cell. Biol. 2006
Participants
Participant Of
Normal reaction
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created