NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter

Stable Identifier
R-HSA-2976563
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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GZMB (granzyme B) promoter contains several RBPJ binding elements (RBEs). NOTCH2 coactivator complex occupies the proximal RBE and at the same time interacts with phosphorylated CREB1, bound to an adjacent CRE site. EP300 transcriptional coactivator is also recruited to this complex through association with CREB1 (Maekawa et al. 2008).

Literature References
PubMed ID Title Journal Year
18724371 Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity

Maekawa, Y, Minato, Y, Ishifune, C, Kurihara, T, Kitamura, A, Kojima, H, Yagita, H, Sakata-Yanagimoto, M, Saito, T, Taniuchi, I, Chiba, S, Sone, S, Yasutomo, K

Nat. Immunol. 2008
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