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ARHGEF4 [cytosol]
Stable Identifier
R-HSA-2976635
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Rho guanine nucleotide exchange factor 4, ARHG4_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF4 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
ARHGEF4 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
ARHGEF4 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
ARHGEF4 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
ARHGEF4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NR80 ARHGEF4
Gene Names
ARHGEF4, KIAA1112
Chain
chain:1-690
Reference Genes
BioGPS Gene:50649 ARHGEF4
COSMIC (genes):ARHGEF4 ARHGEF4
CTD Gene:50649 ARHGEF4
dbSNP Gene:50649 ARHGEF4
ENSEMBL:ENSG00000136002 ARHGEF4
HGNC:684 ARHGEF4
KEGG:hsa:50649 ARHGEF4
Monarch:50649 ARHGEF4
NCBI Gene:50649 ARHGEF4
OMIM:605216 ARHGEF4
UCSC:Q9NR80 ARHGEF4
Reference Transcript
RefSeq:NM_015320.3 ARHGEF4
RefSeq:NM_032995.2 ARHGEF4
Participates
as a candidate of
RHOA GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
as a member of
CDC42 GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
Cross References
ENSEMBL
ENST00000355771
,
ENSP00000348017
,
ENST00000326016
,
ENSG00000136002
,
ENSP00000316845
OpenTargets
ENSG00000136002
GeneCards
ARHGEF4
HPA
ENSG00000136002-ARHGEF4
PRO
Q9NR80
Pharos - Targets
Q9NR80
HMDB Protein
HMDBP11493
PDB
2DX1
,
3NMX
,
2PZ1
,
3NMZ
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.483
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.483
2
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