Reactome | BCL2L11 [cytosol]

BCL2L11 [cytosol]

Stable Identifier

R-HSA-2976673

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Bcl-2-like protein 11, B2L11_HUMAN, BIM

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Activation of BH3-only proteins (Homo sapiens)
      - Activation of BIM and translocation to mitochondria (Homo sapiens)
        
        Phosphorylation of BIM by JNK (Homo sapiens)
        
        BIM sequestered to dynein (DLC1) [plasma membrane] (Homo sapiens)
        
        BCL2L11 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43521 BCL2L11

Gene Names

BCL2L11, BIM

Chain

chain:1-198

Reference Genes

BioGPS Gene:10018 BCL2L11

COSMIC (genes):BCL2L11 BCL2L11

CTD Gene:10018 BCL2L11

dbSNP Gene:10018 BCL2L11

ENSEMBL:ENSG00000153094 BCL2L11

HGNC:994 BCL2L11

KEGG:hsa:10018 BCL2L11

Monarch:10018 BCL2L11

NCBI Gene:10018 BCL2L11

OMIM:603827 BCL2L11

UCSC:O43521 BCL2L11

Reference Transcript

Participates

as an output of

as an input of

JNK phosphorylates BIM, BAD and other targets (Homo sapiens)

as a component of

BIM sequestered to dynein (DLC1) [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-BCL2L11 [cytosol]

p-BCL2L11 [mitochondrial outer membrane]

BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol]

BCL2L11(1-131)-BRAF(397-766) fusion [cytosol]

p-S69-BCL2L11 [cytosol]

BCL2L11 [mitochondrial outer membrane]

Inferred To

BCL2L11 [cytosol] (Bos taurus)

BCL2L11 [cytosol] (Canis familiaris)

BCL2L11 [cytosol] (Sus scrofa)

MEI1 [cytosol] (Gallus gallus)

Bcl2l11 [cytosol] (Mus musculus)

Bcl2l11 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_047298055.1, NP_619532.1, NP_996886.1, NP_001191039.1, NP_001191038.1, NP_619531.1, NP_001191042.1, NP_619527.1, NP_619530.1, NP_001191040.1, NP_619529.1, NP_001191041.1, NP_619528.1, NP_001191037.1, NP_619533.1, XP_047298057.1, NP_001191036.1, NP_001191035.1, NP_996885.1, XP_005263616.2, NP_006529.1

OpenTargets

ENSG00000153094

ENSEMBL

ENST00000452231, ENSP00000384641, ENST00000431217, ENST00000393256, ENSP00000403727, ENST00000405953, ENST00000715206, ENSG00000153094, ENSP00000376943, ENST00000415458, ENST00000308659, ENST00000437029, ENST00000436733, ENSP00000520413, ENSP00000411137, ENSP00000394640, ENSP00000412892, ENSP00000309226, ENST00000439718, ENSP00000393781, ENSP00000391292

GeneCards

BCL2L11

HPA

ENSG00000153094-BCL2L11

PRO

O43521

Pharos - Targets

O43521

PDB

3KJ1, 3KJ0, 2K7W, 5VX3, 4YJ4, 5AGW, 5AGX, 2NL9, 4A1W, 5VX2, 4UF3, 2WH6, 6QFI, 4B4S, 4D2M, 5VWZ, 5C3G, 6UA3, 6X8O, 5WOS, 6UAB, 6VBX, 3KJ2, 6TQQ, 8T5E, 4QVF, 4A1U, 4ZIH, 2V6Q, 5VX0, 3IO8, 4ZIF, 4ZIE, 1F95, 5VWW, 3FDL, 5VWV, 3IO9, 2VM6, 5VWY, 2YQ7, 3D7V, 2YQ6, 5VWX, 6RJP

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.951	20
UniProt:Q07812 BAX	3	BAX [mitochondrial outer membrane] (R-HSA-139949) BAX activated [cytosol] (R-HSA-139907) BAX [cytosol] (R-HSA-139916)	0.943	22
UniProt:Q07817-1 BCL2L1			0.935	10
UniProt:Q92843 B2CL2			0.93	11
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.926	11
UniProt:Q07817 BCL2L1	2	BCL2L1 [mitochondrial outer membrane] (R-HSA-114236) BCL2L1 [cytosol] (R-HSA-50771)	0.866	12
UniProt:Q9HD36 B2L10			0.832	11
UniProt:P97287 MCL1			0.796	7
UniProt:Q16548 BCL2A1	1	BCL2A1 [cytosol] (R-HSA-9725307)	0.683	4
UniProt:P68451 PG045			0.621	4
UniProt:Q07440 B2LA1			0.609	2
UniProt:O43521 BCL2L11	7	BCL2L11 [cytosol] (R-HSA-2976673) p-BCL2L11 [cytosol] (R-HSA-140525) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674)	0.589	2
UniProt:Q07813-1 BAX			0.558	7
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.556	3
UniProt:P43364-2 MAGEA11			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:A6NP61 ZAR1L			0.527	2
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.527	2
UniProt:Q504Y0 S39AC			0.527	2
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.527	2
UniProt:P03495 NS1			0.508	2
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.499	2

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