Reactome | CRK [cytosol]

CRK [cytosol]

Stable Identifier

R-HSA-2980677

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Adapter molecule crk, CRK_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        CRKII:DOCK180:ELMO binds FCGR3A (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        CRK [cytosol] (Homo sapiens)
        
        IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMO [plasma membrane] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        CRK [cytosol] (Homo sapiens)
        
        DOCK180 exchanges GTP for GDP on RAC1:GDP (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        CRK [cytosol] (Homo sapiens)
        
        IgG:Leishmania surface:p-FCGR3A:p-6Y-SYK:CRKII:DOCK180:ELMO [plasma membrane] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        CRK [cytosol] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Platelet Aggregation (Plug Formation) (Homo sapiens)
    - Integrin signaling (Homo sapiens)
      - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
        
        Crk binding to p130cas (Homo sapiens)
        
        CRK [cytosol] (Homo sapiens)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        CRK [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46108 CRK

Gene Names

CRK

Chain

initiator methionine:, chain:2-304

Reference Genes

BioGPS Gene:1398 CRK

COSMIC (genes):CRK CRK

CTD Gene:1398 CRK

dbSNP Gene:1398 CRK

ENSEMBL:ENSG00000167193 CRK

ENSEMBL_homo_sapiens_GENE:ENSG00000167193.8 CRK

HGNC:2362 CRK

KEGG Gene (Homo sapiens):1398 CRK

Monarch:1398 CRK

NCBI Gene:1398 CRK

OMIM:164762 CRK

UCSC:P46108 CRK

Reference Transcript

Other Identifiers

11725320_x_at

11725321_a_at

11736647_s_at

1398

16839345

202224_PM_at

202224_at

202225_PM_at

202225_at

202226_PM_s_at

202226_s_at

3205250

3740172

3740173

3740174

3740175

3740177

3740178

3740179

3740180

3740181

38219_at

49090_at

772_at

8011018

A_23_P83556

A_24_P270814

D10656_at

GE57045

GO:0001764

GO:0001784

GO:0001878

GO:0002376

GO:0002685

GO:0005159

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006357

GO:0006629

GO:0007010

GO:0007155

GO:0007163

GO:0007165

GO:0007167

GO:0008092

GO:0008283

GO:0008360

GO:0009966

GO:0014911

GO:0015629

GO:0016020

GO:0016358

GO:0016477

GO:0017124

GO:0019899

GO:0019900

GO:0019904

GO:0021766

GO:0021987

GO:0023052

GO:0030010

GO:0030036

GO:0030154

GO:0030159

GO:0030307

GO:0030674

GO:0030971

GO:0031594

GO:0031625

GO:0032956

GO:0032991

GO:0033628

GO:0034330

GO:0035020

GO:0035022

GO:0035591

GO:0035685

GO:0035728

GO:0038026

GO:0042060

GO:0042169

GO:0042542

GO:0043087

GO:0043226

GO:0043393

GO:0043621

GO:0045309

GO:0045953

GO:0046330

GO:0046875

GO:0048013

GO:0048856

GO:0048870

GO:0050773

GO:0060090

GO:0060326

GO:0061024

GO:0061045

GO:0061847

GO:0070062

GO:0071560

GO:0071732

GO:0072657

GO:0097110

GO:0098542

GO:0098698

GO:0098749

GO:1900026

GO:1901652

GO:1902531

GO:1904395

GO:1990090

GO:1990314

GO:1990782

GO:1990859

GO:2000145

GO:2000146

GO:2000404

HMNXSV003021767

Hs.306088.0.A2_3p_at

Hs.306088.0.A3_3p_at

ILMN_1666494

ILMN_1686805

ILMN_1803302

PH_hs_0016623

PH_hs_0026639

TC17000973.hg

TC17002435.hg

g8400705_3p_a_at

Participates

as a component of

as an input of

as a member of

CRK, CRKL [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of CRK [cytosol] (Dictyostelium discoideum)

ced-2 [cytosol] (Caenorhabditis elegans)

CRK [cytosol] (Bos taurus)

CRK [cytosol] (Canis familiaris)

CRK [cytosol] (Gallus gallus)

CRK [cytosol] (Sus scrofa)

Crk [cytosol] (Drosophila melanogaster)

Crk [cytosol] (Mus musculus)

Crk [cytosol] (Rattus norvegicus)

crk [cytosol] (Danio rerio)

crk [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_058431.2, NP_005197.3

OpenTargets

ENSG00000167193

GeneCards

P46108

HPA

ENSG00000167193-CRK

Ensembl

ENSG00000167193, ENST00000300574, ENST00000398970, ENSP00000300574, ENSP00000381942

PRO

P46108

Pharos - Targets

P46108

PDB

2EYZ, 2EYX, 5UL6, 2EYY, 2EYV, 6ATV, 1JU5, 2MS4, 2DVJ, 2EYW

Interactors (78)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.919	13
UniProt:P56945 BCAR1	4	p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.816	7
UniProt:Q13905 RAPGEF1	2	RAPGEF1 [cytosol] (R-HSA-913472) RAPGEF1 [endosome] (R-HSA-3008667)	0.813	7
UniProt:Q70EK8 UBP53			0.795	11
UniProt:Q07889 SOS1	3	p-4S-SOS1 [cytosol] (R-HSA-109821) SOS1 [plasma membrane] (R-HSA-983559) SOS1 [cytosol] (R-HSA-64847)	0.792	6
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.781	10
UniProt:P54253 ATX1			0.77	9
UniProt:Q14185 DOCK1	1	DOCK1 [cytosol] (R-HSA-372654)	0.77	5
UniProt:P42684 ABL2	1	ABL2 [cytosol] (R-HSA-375998)	0.77	6
UniProt:Q8TDY4 ASAP3			0.765	6
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.744	5
UniProt:Q8ND30 PPFIBP2	1	PPFIBP2 [cytosol] (R-HSA-6799320)	0.743	5
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.709	5
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.692	4
UniProt:Q9H7D0 DOCK5	1	DOCK5 [cytosol] (R-HSA-1012991)	0.688	4
UniProt:P16234 PDGFRA	20	PDGFRA L629P [plasma membrane] (R-HSA-9673596) PDGFRA N659K [plasma membrane] (R-HSA-9671535) PDGFRA T674I [plasma membrane] (R-HSA-9673603) PDGFRA S601P [plasma membrane] (R-HSA-9673600) PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971) PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673609) p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027) p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673634) PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526) PDGFRA D842Y [plasma membrane] (R-HSA-9671956) PDGFRA D842V [plasma membrane] (R-HSA-9671549) PDGFRA I843_D846del [plasma membrane] (R-HSA-9671537) PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545) PDGFRA D842del [plasma membrane] (R-HSA-9671538) PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563) PDGFRA D846Y [plasma membrane] (R-HSA-9671958) PDGFRA D843_845del [plasma membrane] (R-HSA-9671552) PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547) PDGFRA N848K [plasma membrane] (R-HSA-9671961) PDGFRA Y849C [plasma membrane] (R-HSA-9671974)	0.671	4
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.669	5
UniProt:Q07890 SOS2	1	SOS2 [cytosol] (R-HSA-167221)	0.669	3
UniProt:Q7L190 DPPA4	1	DPPA4 [nucleoplasm] (R-HSA-452999)	0.666	4
UniProt:Q9H706 GARE1			0.646	3
UniProt:Q9H792 PEAK1	1	PEAK1 [cytosol] (R-HSA-9715162)	0.643	4
UniProt:Q6P2E9 EDC4	1	EDC4 [cytosol] (R-HSA-429963)	0.643	4
UniProt:P42566 EPS15	2	p-Y849 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.643	5
UniProt:Q9Y4K4 M4K5			0.641	5
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.635	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.621	3
UniProt:Q9NZM4 BICRA			0.609	2
UniProt:Q96T58 SPEN	1	SPEN [cytosol] (R-HSA-9715142)	0.609	2
UniProt:P41970 ELK3			0.601	4
UniProt:Q9BRX9 WDR83	1	WDR83 [endosome membrane] (R-HSA-5672942)	0.592	2
UniProt:O43683 BUB1	1	BUB1 [cytosol] (R-HSA-377888)	0.592	2
UniProt:A7KAX9 ARHGAP32	1	ARHGAP32 [cytosol] (R-HSA-195134)	0.59	3
UniProt:P10721 KIT	20	KIT C443Y [plasma membrane] (R-HSA-9680045) KIT T417_D419delinsY [plasma membrane] (R-HSA-9680110) KIT S476I [plasma membrane] (R-HSA-9680090) KIT K509I [plasma membrane] (R-HSA-9680177) KIT D419A [plasma membrane] (R-HSA-9680051) KIT D419del [plasma membrane] (R-HSA-9680079) KIT S501_A502dup [plasma membrane] (R-HSA-9680105) KIT D419G [plasma membrane] (R-HSA-9680057) KIT N505_F508dup [plasma membrane] (R-HSA-9680085) KIT C443S [plasma membrane] (R-HSA-9680038) KIT D419N [plasma membrane] (R-HSA-9680071) KIT S476N [plasma membrane] (R-HSA-9680097) KIT D419H [plasma membrane] (R-HSA-9680066) KIT V560_L576del [plasma membrane] (R-HSA-9670336) KIT Y823N [plasma membrane] (R-HSA-9669591) KIT Y823C [plasma membrane] (R-HSA-9669585) p6Y-KIT Y823D [plasma membrane] (R-HSA-9669628) p7Y-KIT D816V [plasma membrane] (R-HSA-9669612) p7Y-KIT K642E [plasma membrane] (R-HSA-9669596) p7Y-KIT N822K [plasma membrane] (R-HSA-9669617)	0.59	4
UniProt:Q92918 M4K1			0.589	3
UniProt:Q8TB24 RIN3	1	RIN3 [cytosol] (R-HSA-8875292)	0.573	2
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q6P1W5 CA094			0.556	3
UniProt:Q96Q35-2 FLACC1			0.556	3
UniProt:Q8IYX7 SAXO1			0.556	3
UniProt:P42681 TXK	3	TXK [cytosol] (R-HSA-3448733) p-Y91,Y420-TXK [cytosol] (R-HSA-3448740) p-Y420-TXK [cytosol] (R-HSA-3448734)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P29074 PTPN4	2	PTPN4 [nucleoplasm] (R-HSA-9008925) PTPN4 [cytosol] (R-HSA-8877173)	0.543	3
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.536	3
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.536	2
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.527	4
UniProt:Q96P48 ARAP1	2	ARAP1 [cytosol] (R-HSA-3211582) p-Y231-ARAP1 [cytosol] (R-HSA-8848869)	0.527	3
UniProt:Q8IU60 DCP2	1	DCP2 [cytosol] (R-HSA-429937)	0.527	3
UniProt:A6NI28 ARHGAP42	1	ARHGAP42 [cytosol] (R-HSA-8873908)	0.527	3
UniProt:Q96JJ3 ELMO2	1	ELMO2 [cytosol] (R-HSA-372642)	0.527	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.527	3
UniProt:Q86YV5 SGK223	1	PRAG1 [cytosol] (R-HSA-9696532)	0.527	3
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.508	2
UniProt:Q96DX5 ASB9	1	ASB9 [cytosol] (R-HSA-975424)	0.508	2
UniProt:O40931 O40931			0.499	2
UniProt:O13016 PTN1			0.489	2
UniProt:Q8WZ19 KCTD13	1	KCTD13 [cytosol] (R-HSA-9696533)	0.488	2
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.488	2
UniProt:Q12841 FSTL1	3	FSTL1 [extracellular region] (R-HSA-201832) p-FSTL1 [endoplasmic reticulum lumen] (R-HSA-8957089) FSTL1 [endoplasmic reticulum lumen] (R-HSA-8956749)	0.488	2
UniProt:Q99645 EPYC			0.488	2
UniProt:P29372-4 MPG			0.488	2
UniProt:P27986-2 PIK3R1			0.488	2
UniProt:P42684-3 ABL2			0.488	2
UniProt:Q92854 SEMA4D	1	SEMA4D [plasma membrane] (R-HSA-197744)	0.488	2
UniProt:Q9Y3I0 RTCB	1	RTCB [nucleoplasm] (R-HSA-5696792)	0.488	2
UniProt:Q14847 LASP1			0.488	2
UniProt:Q9UKT9 IKZF3			0.488	2
UniProt:Q14765 STAT4	4	p-Y693-STAT4 [nucleoplasm] (R-HSA-8950636) p-STAT4 [cytosol] (R-HSA-8950350) p-Y693-STAT4 [cytosol] (R-HSA-8950343) STAT4 [cytosol] (R-HSA-8950606)	0.488	2
UniProt:Q7L591-3 DOK3			0.488	2
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.488	2
UniProt:O14669 TMG2			0.488	2
UniProt:Q8N448 LNX2			0.488	2
UniProt:P19419 ELK1	2	ELK1 [nucleoplasm] (R-HSA-3009346) p-4S,T336-ELK1 [nucleoplasm] (R-HSA-3009350)	0.488	2
UniProt:O60496 DOK2	1	DOK2 [cytosol] (R-HSA-204823)	0.488	2
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.483	2
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.483	2
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.483	3
UniProt:O14654 IRS4	2	p-Y-IRS4 [plasma membrane] (R-HSA-2424302) IRS4 [plasma membrane] (R-HSA-2424297)	0.462	8
UniProt:A9UF07 A9UF07			0.462	4

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