Activation of NIMA Kinases NEK9, NEK6, NEK7

Stable Identifier
R-HSA-2980767
Type
Pathway
Species
Homo sapiens
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NEK6 and NEK7 are activated during mitosis by another NIMA family kinase, NEK9 (Belham et al. 2003, Richards et al. 2009), which is activated by CDK1- and PLK1-mediated phosphorylation (Roig et al. 2002, Bertran et al. 2011).

Literature References
PubMed ID Title Journal Year
21642957 Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5

Bertran, MT, Sdelci, S, Regué, L, Avruch, J, Caelles, C, Roig, J

EMBO J. 2011
19941817 An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9

Richards, MW, O'Regan, L, Mas-Droux, C, Blot, JM, Cheung, J, Hoelder, S, Fry, AM, Bayliss, R

Mol. Cell 2009
12840024 A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases

Belham, C, Roig, J, Caldwell, JA, Aoyama, Y, Kemp, BE, Comb, M, Avruch, J

J. Biol. Chem. 2003
12101123 Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression

Roig, J, Mikhailov, A, Belham, C, Avruch, J

Genes Dev. 2002
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