Reactome | SNAI1 [nucleoplasm]

SNAI1 [nucleoplasm]

Stable Identifier

R-HSA-2980903

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Zinc finger protein SNAI1, SNAI1_HUMAN, Protein snail homolog 1, SNAH, Snail1

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
        
        Regulation of CDH11 Expression and Function (Homo sapiens)
        
        Regulation of CDH11 gene transcription (Homo sapiens)
        
        CDH11 gene is transcribed into nascent CDH11 mRNA (Homo sapiens)
        
        SNAI1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95863 SNAI1

Gene Names

SNAI1, SNAH

Chain

chain:1-264

Reference Genes

BioGPS Gene:6615 SNAI1

COSMIC (genes):SNAI1 SNAI1

CTD Gene:6615 SNAI1

dbSNP Gene:6615 SNAI1

ENSEMBL:ENSG00000124216 SNAI1

ENSEMBL_homo_sapiens_GENE:ENSG00000124216.4 SNAI1

HGNC:11128 SNAI1

KEGG Gene (Homo sapiens):6615 SNAI1

Monarch:6615 SNAI1

NCBI Gene:6615 SNAI1

OMIM:604238 SNAI1

UCSC:O95863 SNAI1

Reference Transcript

RefSeq:NM_005985.3 SNAI1

Other Identifiers

11720513_at

16914791

219480_PM_at

219480_at

3888528

3888529

3888530

3888531

3888532

53649_at

6615

8063382

A_23_P131846

GE79727

GO:0000122

GO:0000977

GO:0000978

GO:0001227

GO:0001649

GO:0001650

GO:0001707

GO:0001837

GO:0003180

GO:0003198

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005721

GO:0005730

GO:0005737

GO:0005829

GO:0006325

GO:0006351

GO:0006355

GO:0006357

GO:0006629

GO:0006766

GO:0007219

GO:0007498

GO:0010631

GO:0010718

GO:0010957

GO:0012501

GO:0019900

GO:0022414

GO:0023052

GO:0030154

GO:0030335

GO:0031069

GO:0034330

GO:0043226

GO:0043231

GO:0043518

GO:0043565

GO:0045892

GO:0045893

GO:0046872

GO:0048856

GO:0048870

GO:0060021

GO:0060070

GO:0060536

GO:0060707

GO:0060806

GO:0060972

GO:0070828

GO:0070888

GO:0140110

GO:1902230

GO:1990837

GO:2000810

HMNXSV003013402

ILMN_1758086

PH_hs_0028893

TC20000395.hg

g5174686_3p_at

Participates

as a component of

as an input of

as an output of

Expression of SNAI1 during gastrulation (Homo sapiens)

as a member of

SNAI1,SNAI2 [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

CDH11 gene is transcribed into nascent CDH11 mRNA (Homo sapiens)

Inferred To

Snai1 [nucleoplasm] (Mus musculus)

Snai1 [nucleoplasm] (Rattus norvegicus)

esg [nucleoplasm] (Drosophila melanogaster)

snai3 [nucleoplasm] (Danio rerio)

Homologues of SNAI1 [nucleoplasm] (Danio rerio)

snai2 [nucleoplasm] (Danio rerio)

snai2 [nucleoplasm] (Xenopus tropicalis)

SNAI1 [nucleoplasm] (Bos taurus)

SNAI1 [nucleoplasm] (Canis familiaris)

SNAI1 [nucleoplasm] (Gallus gallus)

SNAI1 [nucleoplasm] (Plasmodium falciparum)

SNAI1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_005976.2

OpenTargets

ENSG00000124216

GeneCards

O95863

HPA

ENSG00000124216-SNAI1

Ensembl

ENSP00000244050, ENST00000244050, ENSG00000124216

PRO

O95863

Pharos - Targets

O95863

HMDB Protein

HMDBP14022

PDB

2Y48, 4QLI, 3W5K, 3ZMT

Interactors (38)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.835	33
UniProt:P36406 TRI23			0.781	7
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.781	7
UniProt:Q04206 RELA	7	MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S536-RELA [nucleoplasm] (R-HSA-9861499) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.693	5
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.666	4
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.666	4
UniProt:Q7Z3S9 NOTCH2NLA	1	NOTCH2NLA [extracellular region] (R-HSA-9908935)	0.666	4
UniProt:Q15654 TRIP6			0.666	4
UniProt:Q9UKL0 RCOR1	1	RCOR1 [nucleoplasm] (R-HSA-996766)	0.643	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.642	3
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.564	5
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.564	2
UniProt:Q96IF1 AJUBA	3	AJUBA [cytosol] (R-HSA-2564698) p-S-AJUBA [cytosol] (R-HSA-2574841) AJUBA [nucleoplasm] (R-HSA-5687935)	0.558	3
UniProt:Q99471 PFDN5	1	PFDN5 [cytosol] (R-HSA-379548)	0.556	3
UniProt:Q9UJV3-2 MID2			0.556	3
UniProt:Q96B26 EXOSC8	2	EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [cytosol] (R-HSA-429912)	0.556	3
UniProt:Q92990 GLMN	1	GLMN [cytosol] (R-HSA-8951779)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q5JVL4 EFHC1			0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q08043 ACTN3	1	ACTN3 [cytosol] (R-HSA-390565)	0.556	3
UniProt:Q9Y2V7 COG6	2	COG6 [Golgi membrane] (R-HSA-2980958) COG6 [trans-Golgi network membrane] (R-HSA-6813872)	0.556	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:P63085 Mapk1	9	phospho-p-T185,Y187-MAPK1 [nucleoplasm] (R-MMU-112354) phospho-p-T185,Y187-MAPK1 [cytosol] (R-MMU-109853) MAPK1 [cytosol] (R-MMU-59282) MAPK1 [nucleoplasm] (R-MMU-199960) p-T183,Y185-Mapk1 [nucleoplasm] (R-MMU-198682) phospho-p-T185-MAPK1 [cytosol] (R-MMU-9635773) MAPK1 [azurophil granule lumen] (R-MMU-6799225) MAPK1 [extracellular region] (R-MMU-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-MMU-6800964)	0.544	3
UniProt:Q96CD0 FBXL8	1	FBXL8 [cytosol] (R-HSA-8850912)	0.527	2
UniProt:Q9NP66 HM20A			0.527	2
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.525	3
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.525	2
UniProt:Q86XK2 FBXO11	1	FBXO11 [cytosol] (R-HSA-8955092)	0.524	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.524	2
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.504	9
UniProt:Q9NRM7 LATS2	2	p-S872,T1041-LATS2 [cytosol] (R-HSA-2028565) LATS2 [cytosol] (R-HSA-2028580)	0.499	2
UniProt:P45481 Crebbp	4	CREBBP [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.499	7
UniProt:P09874 PARP1	4	polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.463	10
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.462	2

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