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SNAI1 [nucleoplasm]
Stable Identifier
R-HSA-2980903
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Zinc finger protein SNAI1, SNAI1_HUMAN, Protein snail homolog 1, SNAH, Snail1
Locations in the PathwayBrowser for interactor UniProt:P45481 Crebbp
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type II Classical Cadherins (Homo sapiens)
Regulation of CDH11 Expression and Function (Homo sapiens)
Regulation of CDH11 gene transcription (Homo sapiens)
CDH11 gene is transcribed into nascent CDH11 mRNA (Homo sapiens)
SNAI1 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Epithelial-Mesenchymal Transition (EMT) during gastrulation (Homo sapiens)
Expression of SNAI1 during gastrulation (Homo sapiens)
SNAI1 [nucleoplasm] (Homo sapiens)
SNAI1 binds the CDH1 gene (Homo sapiens)
SNAI1 [nucleoplasm] (Homo sapiens)
SNAI1 binds the CLDN7 gene (Homo sapiens)
SNAI1 [nucleoplasm] (Homo sapiens)
SNAI1 binds the OCLN gene (Homo sapiens)
SNAI1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95863 SNAI1
Gene Names
SNAI1, SNAH
Chain
chain:1-264
Reference Genes
BioGPS Gene:6615 SNAI1
COSMIC (genes):SNAI1 SNAI1
CTD Gene:6615 SNAI1
dbSNP Gene:6615 SNAI1
ENSEMBL:ENSG00000124216 SNAI1
ENSEMBL_homo_sapiens_GENE:ENSG00000124216.4 SNAI1
HGNC:11128 SNAI1
KEGG Gene (Homo sapiens):6615 SNAI1
Monarch:6615 SNAI1
NCBI Gene:6615 SNAI1
OMIM:604238 SNAI1
UCSC:O95863 SNAI1
Reference Transcript
RefSeq:NM_005985.3 SNAI1
Other Identifiers
11720513_at
16914791
219480_PM_at
219480_at
3888528
3888529
3888530
3888531
3888532
53649_at
6615
8063382
A_23_P131846
GE79727
GO:0000122
GO:0000977
GO:0000978
GO:0001227
GO:0001649
GO:0001650
GO:0001707
GO:0001837
GO:0003180
GO:0003198
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005721
GO:0005730
GO:0005737
GO:0005829
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006629
GO:0006766
GO:0007219
GO:0007498
GO:0010631
GO:0010718
GO:0010957
GO:0012501
GO:0019900
GO:0022414
GO:0023052
GO:0030154
GO:0030335
GO:0031069
GO:0034330
GO:0043226
GO:0043231
GO:0043518
GO:0043565
GO:0045892
GO:0045893
GO:0046872
GO:0048856
GO:0048870
GO:0060021
GO:0060070
GO:0060536
GO:0060707
GO:0060806
GO:0060972
GO:0070828
GO:0070888
GO:0140110
GO:1902230
GO:1990837
GO:2000810
HMNXSV003013402
ILMN_1758086
PH_hs_0028893
TC20000395.hg
g5174686_3p_at
Participates
as a component of
SNAI1:CDH1 gene [nucleoplasm] (Homo sapiens)
SNAI1:OCLN gene [nucleoplasm] (Homo sapiens)
SNAI1:CLDN7 gene [nucleoplasm] (Homo sapiens)
as an input of
SNAI1 binds the CDH1 gene (Homo sapiens)
SNAI1 binds the OCLN gene (Homo sapiens)
SNAI1 binds the CLDN7 gene (Homo sapiens)
as an output of
Expression of SNAI1 during gastrulation (Homo sapiens)
as a member of
SNAI1,SNAI2 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
CDH11 gene is transcribed into nascent CDH11 mRNA
(Homo sapiens)
Inferred To
Snai1 [nucleoplasm]
(Mus musculus)
Snai1 [nucleoplasm]
(Rattus norvegicus)
esg [nucleoplasm]
(Drosophila melanogaster)
snai3 [nucleoplasm]
(Danio rerio)
Homologues of SNAI1 [nucleoplasm]
(Danio rerio)
snai2 [nucleoplasm]
(Danio rerio)
snai2 [nucleoplasm]
(Xenopus tropicalis)
SNAI1 [nucleoplasm]
(Bos taurus)
SNAI1 [nucleoplasm]
(Canis familiaris)
SNAI1 [nucleoplasm]
(Gallus gallus)
SNAI1 [nucleoplasm]
(Plasmodium falciparum)
SNAI1 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_005976.2
OpenTargets
ENSG00000124216
GeneCards
O95863
HPA
ENSG00000124216-SNAI1
Ensembl
ENSP00000244050
,
ENST00000244050
,
ENSG00000124216
PRO
O95863
Pharos - Targets
O95863
HMDB Protein
HMDBP14022
PDB
2Y48
,
4QLI
,
3W5K
,
3ZMT
Interactors (38)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.835
33
UniProt:P36406 TRI23
0.781
7
UniProt:P35609 ACTN2
3
ACTN2 [cytosol]
(R-HSA-390562)
ACTN2 [platelet alpha granule lumen]
(R-HSA-349727)
ACTN2 [extracellular region]
(R-HSA-349725)
0.781
7
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.693
5
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.666
4
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.666
4
UniProt:Q7Z3S9 NOTCH2NLA
1
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
0.666
4
UniProt:Q15654 TRIP6
0.666
4
UniProt:Q9UKL0 RCOR1
1
RCOR1 [nucleoplasm]
(R-HSA-996766)
0.643
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.642
3
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.564
5
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.564
2
UniProt:Q96IF1 AJUBA
3
AJUBA [cytosol]
(R-HSA-2564698)
p-S-AJUBA [cytosol]
(R-HSA-2574841)
AJUBA [nucleoplasm]
(R-HSA-5687935)
0.558
3
UniProt:Q99471 PFDN5
1
PFDN5 [cytosol]
(R-HSA-379548)
0.556
3
UniProt:Q9UJV3-2 MID2
0.556
3
UniProt:Q96B26 EXOSC8
2
EXOSC8 [nucleoplasm]
(R-HSA-6791571)
EXOSC8 [cytosol]
(R-HSA-429912)
0.556
3
UniProt:Q92990 GLMN
1
GLMN [cytosol]
(R-HSA-8951779)
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:Q5JVL4 EFHC1
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:Q08043 ACTN3
1
ACTN3 [cytosol]
(R-HSA-390565)
0.556
3
UniProt:Q9Y2V7 COG6
2
COG6 [Golgi membrane]
(R-HSA-2980958)
COG6 [trans-Golgi network membrane]
(R-HSA-6813872)
0.556
3
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:P63085 Mapk1
9
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
(R-MMU-112354)
phospho-p-T185,Y187-MAPK1 [cytosol]
(R-MMU-109853)
MAPK1 [cytosol]
(R-MMU-59282)
MAPK1 [nucleoplasm]
(R-MMU-199960)
p-T183,Y185-Mapk1 [nucleoplasm]
(R-MMU-198682)
phospho-p-T185-MAPK1 [cytosol]
(R-MMU-9635773)
MAPK1 [azurophil granule lumen]
(R-MMU-6799225)
MAPK1 [extracellular region]
(R-MMU-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-MMU-6800964)
0.544
3
UniProt:Q96CD0 FBXL8
1
FBXL8 [cytosol]
(R-HSA-8850912)
0.527
2
UniProt:Q9NP66 HM20A
0.527
2
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.525
3
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.525
2
UniProt:Q86XK2 FBXO11
1
FBXO11 [cytosol]
(R-HSA-8955092)
0.524
6
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.524
2
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.504
9
UniProt:Q9NRM7 LATS2
2
p-S872,T1041-LATS2 [cytosol]
(R-HSA-2028565)
LATS2 [cytosol]
(R-HSA-2028580)
0.499
2
UniProt:P45481 Crebbp
4
CREBBP [nucleoplasm]
(R-MMU-193545)
Crebbp [nucleoplasm]
(R-MMU-556795)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.499
7
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.463
10
UniProt:Q96ST3 SIN3A
2
SIN3A [nucleoplasm]
(R-HSA-351657)
monoSUMO1-SIN3A [nucleoplasm]
(R-HSA-4086071)
0.462
2
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