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COG6 [Golgi membrane]
Stable Identifier
R-HSA-2980958
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Conserved oligomeric Golgi complex subunit 6, COG6_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Intra-Golgi traffic (Homo sapiens)
Formation of cis-SNARE complex and membrane fusion in intra-Golgi retrograde traffic (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
COG complex:CUX1 dimer:GOLGA5 dimer:STX5:PalmC-YKT6:BET1L:GOSR1:intra-Golgi retrograde cargo [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
The COG complex and CUX1 and GOLGA5 dimers contribute to intra-Golgi vesicle tethering (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
COG complex:CUX1 dimer:GOLGA5 dimer:STX5:PalmC-YKT6:BET1L:GOSR1:intra-Golgi retrograde cargo [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
The COG complex binds RABs at the Golgi membrane (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
COG complex:RABs [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
The COG tethering complex interacts with numerous SNAREs at the Golgi membrane (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
COG complex:Golgi snares [Golgi membrane] (Homo sapiens)
COG complex [Golgi membrane] (Homo sapiens)
COG6 [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2V7 COG6
Gene Names
COG6, KIAA1134
Chain
chain:1-657
Reference Genes
BioGPS Gene:57511 COG6
COSMIC (genes):COG6 COG6
CTD Gene:57511 COG6
dbSNP Gene:57511 COG6
ENSEMBL:ENSG00000133103 COG6
ENSEMBL_homo_sapiens_GENE:ENSG00000133103.17 COG6
HGNC:18621 COG6
KEGG Gene (Homo sapiens):57511 COG6
Monarch:57511 COG6
NCBI Gene:57511 COG6
OMIM:606977 COG6
UCSC:Q9Y2V7 COG6
Reference Transcript
RefSeq:NM_020751.2 COG6
RefSeq:NM_001145079.1 COG6
Other Identifiers
11724048_a_at
11724049_a_at
11739210_at
16774188
225769_PM_at
225769_at
232786_PM_at
232786_at
3486384
3486385
3486386
3486387
3486388
3486389
3486390
3486391
3486392
3486394
3486395
3486400
3486402
3486403
3486404
3486408
3486412
3486413
3486414
3486417
3486418
3486419
3486425
3486426
3486427
3486428
3486429
3486430
3486435
3486436
3486441
48586_at
57511
7968711
84000_at
A_14_P102773
A_14_P105706
A_14_P113837
A_23_P53866
A_24_P290692
GE79281
GE87975
GO:0000139
GO:0000301
GO:0005515
GO:0005794
GO:0006891
GO:0007030
GO:0015031
GO:0016020
GO:0016192
GO:0017119
GO:0032588
GO:0043226
GO:0070085
HMNXSV003035609
HMNXSV003046217
Hs.18282.0.S1_3p_at
Hs.18282.1.S1_3p_at
ILMN_1779530
PH_hs_0025461
PH_hs_0041065
TC13000137.hg
TC13001031.hg
Participates
as a component of
COG complex [Golgi membrane] (Homo sapiens)
Other forms of this molecule
COG6 [trans-Golgi network membrane]
Inferred To
cog6 [Golgi membrane]
(Dictyostelium discoideum)
cog6 [Golgi membrane]
(Schizosaccharomyces pombe)
cog6 [Golgi membrane]
(Xenopus tropicalis)
Cog6 [Golgi membrane]
(Drosophila melanogaster)
Cog6 [Golgi membrane]
(Mus musculus)
Cog6 [Golgi membrane]
(Rattus norvegicus)
COG6 [Golgi membrane]
(Bos taurus)
COG6 [Golgi membrane]
(Canis familiaris)
COG6 [Golgi membrane]
(Gallus gallus)
COG6 [Golgi membrane]
(Sus scrofa)
cogc-6 [Golgi membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_065802.1
,
NP_001138551.1
OpenTargets
ENSG00000133103
HPA
ENSG00000133103-COG6
GeneCards
Q9Y2V7
Ensembl
ENSP00000348983
,
ENST00000356576
,
ENST00000416691
,
ENSP00000403733
,
ENSG00000133103
,
ENSP00000397441
,
ENST00000455146
PRO
Q9Y2V7
Pharos - Targets
Q9Y2V7
Orphanet
22399
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95999 BCL10
3
K48polyUb-BCL10 [cytosol]
(R-HSA-8939329)
BCL10 [cytosol]
(R-HSA-202447)
p-BCL10 [cytosol]
(R-HSA-202488)
0.696
5
UniProt:P55040 GEM
1
GEM [plasma membrane]
(R-HSA-9769962)
0.556
3
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.556
3
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.556
3
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.556
3
UniProt:P55081 MFAP1
1
MFAP1 [nucleoplasm]
(R-HSA-2396419)
0.556
3
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.556
3
UniProt:Q9BV20 MRI1
1
MRI1 [cytosol]
(R-HSA-1237095)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.488
2
UniProt:O15287 FANCG
2
FANCG [nucleoplasm]
(R-HSA-419532)
FANCG [cytosol]
(R-HSA-420788)
0.488
2
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.488
2
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