Reactome | DNM2 [plasma membrane]

DNM2 [plasma membrane]

Stable Identifier

R-HSA-2984201

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Dynamin-2

Locations in the PathwayBrowser for interactor ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Function (Homo sapiens)
        
        Degradation of CDH1 (Homo sapiens)
        
        The complex of MDM2 and CDH1 translocates to early endosomes (Homo sapiens)
        
        DNM2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50570 DNM2

Gene Names

DNM2, DYN2

Chain

chain:1-870

Reference Genes

BioGPS Gene:1785 DNM2

COSMIC (genes):DNM2 DNM2

CTD Gene:1785 DNM2

dbSNP Gene:1785 DNM2

ENSEMBL:ENSG00000079805 DNM2

HGNC:2974 DNM2

KEGG:hsa:1785 DNM2

Monarch:1785 DNM2

NCBI Gene:1785 DNM2

OMIM:602378 DNM2

UCSC:P50570 DNM2

Reference Transcript

Participates

as an input of

eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)

as a component of

as a candidate of

This entity regulates

Positively

The complex of MDM2 and CDH1 translocates to early endosomes (Homo sapiens)

Other forms of this molecule

DNM2 [lysosomal membrane]

DNM2 [cytosol]

DNM2 [endocytic vesicle membrane]

DNM2 [Golgi membrane]

Inferred To

dnm2b [plasma membrane] (Danio rerio)

DNM2 [plasma membrane] (Bos taurus)

DNM2 [plasma membrane] (Canis familiaris)

DNM2 [plasma membrane] (Gallus gallus)

DNM2 [plasma membrane] (Sus scrofa)

Dynamin-2 [plasma membrane] (Rattus norvegicus)

dyn-1 [plasma membrane] (Caenorhabditis elegans)

Dnm2 [plasma membrane] (Mus musculus)

shi [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_004936.2, NP_001177645.1, NP_001005360.1, NP_001005361.1, NP_001005362.1

OpenTargets

ENSG00000079805

ENSEMBL

ENST00000585892, ENST00000389253, ENSP00000386192, ENSG00000079805, ENST00000359692, ENST00000355667, ENSP00000468734, ENSP00000352721, ENST00000408974, ENSP00000347890, ENSP00000373905

ZINC - Substances

DYN2_HUMAN

ZINC target

P50570

PRO

P50570

GlyGen

P50570

PDB

2YS1

IntEnz

3.6.5.5

GeneCards

DNM2

HPA

ENSG00000079805-DNM2

Pharos - Targets

P50570

Orphanet

DNM2

ZINC - Predictions - Purchasable

DYN2_HUMAN

HMDB Protein

HMDBP08364

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.933	11
UniProt:Q9Y5X1 SNX9	3	SNX9 [cytosol] (R-HSA-8867737) SNX9 [Golgi membrane] (R-HSA-432988) SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)	0.918	12
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.78	4
UniProt:Q05193 DNM1	3	DNM1 [plasma membrane] (R-HSA-177488) DNM1 [lysosomal membrane] (R-HSA-196150) DNM1 [cytosol] (R-HSA-2213182)	0.738	6
UniProt:Q99962 SH3GL2	4	SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.722	4
UniProt:P49418 AMPH	1	AMPH [cytosol] (R-HSA-8867728)	0.713	3
UniProt:Q8WV41 SNX33			0.669	5
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.645	5
UniProt:Q9UQ16 DNM3	2	DNM3 [plasma membrane] (R-HSA-443610) DNM3 [cytosol] (R-HSA-2213188)	0.643	5
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.556	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
UniProt:Q9BUZ4 TRAF4			0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	3
UniProt:Q15436 SEC23A	4	SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) p-S738,T744 SEC23A [cytosol] (R-HSA-5685740)	0.556	3
UniProt:P57075-2 UBASH3A			0.556	3
UniProt:Q8NFF5-2 FLAD1			0.556	3
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.556	3
UniProt:Q5HYK7 SH3D19	1	SH3D19 [cytosol] (R-HSA-434202)	0.527	2
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.527	4
UniProt:Q6XZF7 DNMBP	1	DNMBP [cytosol] (R-HSA-9644182)	0.527	2
UniProt:P22392 NME2	4	NME2 [cytosol] (R-HSA-60024) NME2 [ficolin-1-rich granule lumen] (R-HSA-6803324) NME2 [extracellular region] (R-HSA-6806464) NME2 [secretory granule lumen] (R-HSA-6803277)	0.525	2
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.524	5
UniProt:Q9UNF0 PACSIN2	1	PACSIN2 [cytosol] (R-HSA-8868267)	0.524	4
UniProt:Q12965 MYO1E			0.524	2
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.524	3
UniProt:O14645 IDLC			0.508	2
UniProt:Q96RU3 FNBP1	1	FNBP1 [cytosol] (R-HSA-8862261)	0.499	2
UniProt:Q8N157 AHI1	1	AHI1 [cytosol] (R-HSA-6804284)	0.499	2
UniProt:Q96HA8 NTAQ1			0.488	2
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.488	2
UniProt:P50570 DNM2	5	DNM2 [plasma membrane] (R-HSA-2984201) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [cytosol] (R-HSA-2213180) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [Golgi membrane] (R-HSA-2980842)	0.488	2
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE			0.462	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2

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