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DNM2 [plasma membrane]
Stable Identifier
R-HSA-2984201
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Dynamin-2
Locations in the PathwayBrowser for interactor UniProt:Q99962
Expand all
Metabolism (Homo sapiens)
Metabolism of nitric oxide: NOS3 activation and regulation (Homo sapiens)
NOSTRIN mediated eNOS trafficking (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)
DNM2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50570 DNM2
Gene Names
DNM2, DYN2
Chain
chain:1-870
Reference Genes
BioGPS Gene:1785 DNM2
COSMIC (genes):DNM2 DNM2
CTD Gene:1785 DNM2
dbSNP Gene:1785 DNM2
ENSEMBL:ENSG00000079805 DNM2
ENSEMBL_homo_sapiens_GENE:ENSG00000079805.19 DNM2
HGNC:2974 DNM2
KEGG Gene (Homo sapiens):1785 DNM2
Monarch:1785 DNM2
NCBI Gene:1785 DNM2
OMIM:602378 DNM2
UCSC:P50570 DNM2
Reference Transcript
RefSeq:NM_001005360.2 DNM2
RefSeq:NM_004945.3 DNM2
RefSeq:NM_001005362.2 DNM2
RefSeq:NM_001005361.2 DNM2
RefSeq:NM_001190716.1 DNM2
Other Identifiers
11735759_a_at
11741014_x_at
11749116_a_at
1785
202253_PM_s_at
202253_s_at
32622_at
3820759
3820760
3820771
3820777
3820779
3820780
3820781
3820782
3820784
3820786
3820789
3820795
3820797
3820803
3820809
3820813
3820816
3820818
3820820
3820821
3820825
3820827
3820828
3820830
3820831
3820832
3820833
8025741
A_23_P407074
GE57744
GO:0000086
GO:0000139
GO:0000166
GO:0000278
GO:0001891
GO:0002376
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005737
GO:0005794
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0005905
GO:0005925
GO:0006351
GO:0006355
GO:0006892
GO:0006897
GO:0006898
GO:0006909
GO:0007165
GO:0008017
GO:0008092
GO:0012501
GO:0014069
GO:0016020
GO:0016192
GO:0016787
GO:0017124
GO:0019886
GO:0019899
GO:0023052
GO:0030154
GO:0030426
GO:0030496
GO:0030516
GO:0030666
GO:0030670
GO:0031410
GO:0031623
GO:0033572
GO:0042995
GO:0043065
GO:0043226
GO:0045202
GO:0045211
GO:0045893
GO:0048488
GO:0048489
GO:0048812
GO:0048856
GO:0061024
GO:0070062
GO:0070161
GO:0098793
GO:1903526
HMNXSV003025647
ILMN_1656822
ILMN_2339377
L36983_at
PH_hs_0025257
TC19002623.hg
g4826699_3p_a_at
p33942
Participates
as an input of
eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 (Homo sapiens)
as a component of
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Homo sapiens)
eNOS:Caveolin-1:NOSTRIN:dynamin-2:N-WASP [plasma membrane] (Homo sapiens)
as a candidate of
Dynamin-1/2/3 [plasma membrane] (Homo sapiens)
Dynamin [plasma membrane] (Homo sapiens)
Other forms of this molecule
DNM2 [Golgi membrane]
DNM2 [endocytic vesicle membrane]
DNM2 [cytosol]
DNM2 [lysosomal membrane]
Inferred To
DNM2 [plasma membrane]
(Bos taurus)
DNM2 [plasma membrane]
(Caenorhabditis elegans)
DNM2 [plasma membrane]
(Canis familiaris)
DNM2 [plasma membrane]
(Drosophila melanogaster)
DNM2 [plasma membrane]
(Gallus gallus)
DNM2 [plasma membrane]
(Mus musculus)
DNM2 [plasma membrane]
(Sus scrofa)
Dynamin-2 [plasma membrane]
(Rattus norvegicus)
dnm2l [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_001005362.1
,
NP_001005361.1
,
NP_004936.2
,
NP_001177645.1
,
NP_001005360.1
OpenTargets
ENSG00000079805
ZINC - Substances
DYN2_HUMAN
ZINC target
P50570
PRO
P50570
PDB
2YS1
IntEnz
3.6.5.5
HPA
ENSG00000079805-DNM2
GeneCards
P50570
Ensembl
ENSG00000079805
,
ENSP00000386192
,
ENST00000389253
,
ENSP00000373905
,
ENSP00000468734
,
ENSP00000347890
,
ENST00000359692
,
ENST00000355667
,
ENSP00000352721
,
ENST00000585892
,
ENST00000408974
Pharos - Targets
P50570
Orphanet
15882
ZINC - Predictions - Purchasable
DYN2_HUMAN
HMDB Protein
HMDBP08364
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.918
9
UniProt:Q9Y5X1 SNX9
3
SNX9 [cytosol]
(R-HSA-8867737)
SNX9 [Golgi membrane]
(R-HSA-432988)
SNX9 [cytoplasmic vesicle membrane]
(R-HSA-432990)
0.807
8
UniProt:Q99962 SH3GL2
4
SH3GL2 [cytosol]
(R-HSA-182958)
SH3GL2 [plasma membrane]
(R-HSA-177495)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130629)
SH3GL2 [Golgi membrane]
(R-HSA-351189)
0.722
4
UniProt:P49418 AMPH
1
AMPH [cytosol]
(R-HSA-8867728)
0.713
3
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.713
3
UniProt:Q14247 CTTN
2
CTTN [cytosol]
(R-HSA-201894)
p-S113-CTTN [cytosol]
(R-HSA-442842)
0.645
5
UniProt:O76064 RNF8
1
RNF8 [nucleoplasm]
(R-HSA-5682539)
0.556
3
UniProt:Q8NFF5-2 FLAD1
0.556
3
UniProt:P57075-2 UBASH3A
0.556
3
UniProt:Q9BUZ4 TRAF4
0.556
3
IntAct:EBI-22313194 CCSB ORF ID
0.556
3
UniProt:O95817 BAG3
1
BAG3 [cytosol]
(R-HSA-5255451)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:P47897 QARS1
2
QARS [cytosol]
(R-HSA-379615)
QARS [mitochondrial matrix]
(R-HSA-379592)
0.556
3
UniProt:Q15436 SEC23A
4
p-S738,T744 SEC23A [cytosol]
(R-HSA-5685740)
SEC23A [ER to Golgi transport vesicle membrane]
(R-HSA-204024)
SEC23A [cytosol]
(R-HSA-203972)
SEC23A [endoplasmic reticulum membrane]
(R-HSA-203976)
0.556
3
UniProt:P22392 NME2
4
NME2 [secretory granule lumen]
(R-HSA-6803277)
NME2 [extracellular region]
(R-HSA-6806464)
NME2 [ficolin-1-rich granule lumen]
(R-HSA-6803324)
NME2 [cytosol]
(R-HSA-60024)
0.525
2
UniProt:Q12965 MYO1E
0.524
2
UniProt:Q9UNF0 PACSIN2
1
PACSIN2 [cytosol]
(R-HSA-8868267)
0.524
4
UniProt:Q96B97 SH3KBP1
3
SH3KBP1 [plasma membrane]
(R-HSA-182955)
SH3KBP1 [cytosol]
(R-HSA-182957)
Ub-SH3KBP1 [cytosol]
(R-HSA-182926)
0.524
5
UniProt:Q9P0V3 SH3BP4
1
SH3BP4 [cytosol]
(R-HSA-8866227)
0.524
3
UniProt:O14645 IDLC
0.508
2
UniProt:Q8N157 AHI1
1
AHI1 [cytosol]
(R-HSA-6804284)
0.499
2
UniProt:Q96RU3 FNBP1
1
FNBP1 [cytosol]
(R-HSA-8862261)
0.499
2
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.488
2
UniProt:P50570 DNM2
5
DNM2 [Golgi membrane]
(R-HSA-2980842)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
DNM2 [plasma membrane]
(R-HSA-2984201)
0.488
2
UniProt:Q96HA8 NTAQ1
0.488
2
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.488
2
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.488
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE
0.462
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
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