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p-S29,T210,T333,S750,S869-NEK9 [cytosol]
Stable Identifier
R-HSA-2984225
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-3S,2T-NEK9, p-S29,T210,T333,S750,S869-Serine/threonine-protein kinase Nek9, p-S29,T210,T333,S750,S869-NimA-related protein kinase 9
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 binds to microtubules (Homo sapiens)
p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol] (Homo sapiens)
p-3S,2T-NEK9 [cytosol] (Homo sapiens)
p-S29,T210,T333,S750,S869-NEK9 [cytosol] (Homo sapiens)
NEK6 and NEK7 phosphorylate EML4 (Homo sapiens)
p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol] (Homo sapiens)
p-3S,2T-NEK9 [cytosol] (Homo sapiens)
p-S29,T210,T333,S750,S869-NEK9 [cytosol] (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Activation of NIMA Kinases NEK9, NEK6, NEK7 (Homo sapiens)
NEK9 binds NEK6/NEK7 in the cytosol (Homo sapiens)
p-3S,2T-NEK9 [cytosol] (Homo sapiens)
p-S29,T210,T333,S750,S869-NEK9 [cytosol] (Homo sapiens)
p-3S,2T-NEK9:NEK6/NEK7 [cytosol] (Homo sapiens)
p-3S,2T-NEK9 [cytosol] (Homo sapiens)
p-S29,T210,T333,S750,S869-NEK9 [cytosol] (Homo sapiens)
NEK9 phosphorylates NEK6/NEK7 (Homo sapiens)
p-3S,2T-NEK9 [cytosol] (Homo sapiens)
p-S29,T210,T333,S750,S869-NEK9 [cytosol] (Homo sapiens)
p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol] (Homo sapiens)
p-3S,2T-NEK9 [cytosol] (Homo sapiens)
p-S29,T210,T333,S750,S869-NEK9 [cytosol] (Homo sapiens)
p-3S,2T-NEK9:NEK6/NEK7 [cytosol] (Homo sapiens)
p-3S,2T-NEK9 [cytosol] (Homo sapiens)
p-S29,T210,T333,S750,S869-NEK9 [cytosol] (Homo sapiens)
PLK1 phosphorylates NEK9 (Homo sapiens)
p-3S,2T-NEK9 [cytosol] (Homo sapiens)
p-S29,T210,T333,S750,S869-NEK9 [cytosol] (Homo sapiens)
Nuclear Pore Complex (NPC) Disassembly (Homo sapiens)
NEK6/NEK7 phosphorylates NUP98 (Homo sapiens)
p-3S,2T-NEK9: p-S206-NEK6/ p-S195-NEK7 [cytosol] (Homo sapiens)
p-3S,2T-NEK9 [cytosol] (Homo sapiens)
p-S29,T210,T333,S750,S869-NEK9 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TD19 NEK9
Gene Names
NEK9, KIAA1995, NEK8, NERCC
Chain
initiator methionine:, chain:2-979
Reference Genes
BioGPS Gene:91754 NEK9
COSMIC (genes):NEK8 NEK9
COSMIC (genes):NEK9 NEK9
CTD Gene:91754 NEK9
dbSNP Gene:91754 NEK9
ENSEMBL:ENSG00000119638 NEK9
HGNC:18591 NEK9
KEGG:hsa:91754 NEK9
Monarch:91754 NEK9
NCBI Gene:91754 NEK9
OMIM:609798 NEK9
UCSC:Q8TD19 NEK9
Reference Transcript
RefSeq:NM_001329238.1 NEK9
RefSeq:NM_001329237.1 NEK9
RefSeq:NM_033116.5 NEK9
Other Identifiers
11736077_a_at
11736078_a_at
11736079_a_at
16794898
212299_PM_at
212299_at
214738_3p_s_at
214738_PM_s_at
214738_s_at
3572143
3572144
3572279
3572280
3572281
3572282
3572283
3572284
3572285
3572287
3572288
3572289
3572291
3572292
3572293
3572295
3572296
3572297
3572298
3572299
3572300
3572302
3572303
3572304
3572305
3572306
3572307
3572308
3572309
3572310
3572312
3572313
3572314
3572315
3572316
3572318
3572320
3572321
3572322
3572323
3572337
3572339
35843_at
60722_at
7980271
91754
A_23_P3131
A_24_P347480
GE501409
GE56489
GE890268
GE905911
GO:0000278
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0006468
GO:0007346
GO:0016740
GO:0019901
GO:0030295
GO:0043226
GO:0046872
GO:0051301
GO:0098772
GO:0106310
GO:0140096
HMNXSV003034185
Hs.306533.0.S1_3p_s_at
Hs.7200.0.A1_3p_at
ILMN_1847889
PH_hs_0000740
TC14001317.hg
Participates
as a component of
p-3S,2T-NEK9 [cytosol] (Homo sapiens)
Other forms of this molecule
p-T333-NEK9 [cytosol]
p-S29,T333,S750,S869-NEK9 [cytosol]
Inferred To
phospho-NEK9 [cytosol]
(Bos taurus)
phospho-NEK9 [cytosol]
(Canis familiaris)
phospho-NEK9 [cytosol]
(Sus scrofa)
phospho-Nek9 [cytosol]
(Rattus norvegicus)
phospho-p-S29,T210,T333,S750,S869-NEK9 [cytosol]
(Caenorhabditis elegans)
phospho-p-S29,T210,T333,S750,S869-NEK9 [cytosol]
(Gallus gallus)
phospho-p-S29,T210,T333,S750,S869-NEK9 [cytosol]
(Mus musculus)
Modified Residues
Name
O-phospho-L-serine at 29
Coordinate
29
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 210
Coordinate
210
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 333
Coordinate
333
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 750
Coordinate
750
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 869
Coordinate
869
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_149107.4
,
NP_001316166.1
,
NP_001316167.1
ZINC - World Drugs
NEK9_HUMAN
Guide to Pharmacology - Targets
2124
OpenTargets
ENSG00000119638
ENSEMBL
ENSP00000238616
,
ENST00000238616
ZINC - FDA approved
NEK9_HUMAN
ZINC - Substances
NEK9_HUMAN
ZINC target
Q8TD19
ZINC - Biogenic
NEK9_HUMAN
PRO
Q8TD19
GlyGen
Q8TD19
PDB
3ZKE
,
3ZKF
ZINC - Investigational
NEK9_HUMAN
HPA
ENSG00000119638-NEK9
Pharos - Targets
Q8TD19
ZINC - Predictions - Purchasable
NEK9_HUMAN
Orphanet
NEK9
HMDB Protein
HMDBP01300
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P53350 PLK1
4
PLK1 [cytosol]
(R-HSA-164603)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
PLK1 [nucleoplasm]
(R-HSA-156720)
0.625
5
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
0.544
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.524
2
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