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PIAS3 [nucleoplasm]
Stable Identifier
R-HSA-2993764
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 SUMO-protein ligase PIAS3 ecNumber6.3.2.-/ecNumber, PIAS3_HUMAN
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Formation of Incision Complex in GG-NER (Homo sapiens)
SUMOylation of XPC (Homo sapiens)
PIAS1,3 [nucleoplasm] (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
SUMOylation of immune response proteins (Homo sapiens)
PIAS3 SUMOylates RELA with SUMO3 (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS1,3 SUMOylate ESR1 with SUMO1 (Homo sapiens)
PIAS1,3 [nucleoplasm] (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
PIAS1,3 SUMOylates NR5A1 with SUMO1 (Homo sapiens)
PIAS1,3 [nucleoplasm] (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
PIAS1,3 SUMOylates NR5A1 with SUMO2 (Homo sapiens)
PIAS1,3 [nucleoplasm] (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
PIAS2,3,4 SUMOylate RORA with SUMO1 (Homo sapiens)
PIAS2-2,PIAS3,PIAS4 [nucleoplasm] (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
PIAS2,3,4 SUMOylate RORA with SUMO2 (Homo sapiens)
PIAS2-2,PIAS3,PIAS4 [nucleoplasm] (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
PIAS3 SUMOylates PGR with SUMO1 (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PIAS1,3 SUMOylate MBD1 with SUMO1 (Homo sapiens)
PIAS1,3 [nucleoplasm] (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
PIAS1,3 SUMOylate NRIP1 with SUMO1 (Homo sapiens)
PIAS1,3 [nucleoplasm] (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription factors (Homo sapiens)
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)
PIAS1,3,4 [nucleoplasm] (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
PIAS3 SUMOylates MITF with SUMO1 (Homo sapiens)
PIAS3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6X2 PIAS3
Gene Names
PIAS3
Chain
chain:1-628
Reference Genes
BioGPS Gene:10401 PIAS3
COSMIC (genes):PIAS3 PIAS3
CTD Gene:10401 PIAS3
dbSNP Gene:10401 PIAS3
ENSEMBL:ENSG00000131788 PIAS3
HGNC:16861 PIAS3
KEGG:hsa:10401 PIAS3
Monarch:10401 PIAS3
NCBI Gene:10401 PIAS3
OMIM:605987 PIAS3
UCSC:Q9Y6X2 PIAS3
Reference Transcript
RefSeq:NM_006099.3 PIAS3
Other Identifiers
10401
11716860_at
11745793_a_at
11745898_a_at
11757693_s_at
11760123_at
16669905
203035_PM_s_at
203035_s_at
2356304
2356305
2356306
2356308
2356309
2356310
2356311
2356312
2356313
2356314
2356315
2356316
2356317
2356318
2356319
2356320
2356321
2356322
2356323
2356324
2356325
2356326
2356328
2356329
2356330
2356331
2356332
2356333
32558_at
73183_at
7904812
A_14_P129358
A_23_P149678
A_24_P6889
GE53594
GO:0000122
GO:0000785
GO:0003712
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006355
GO:0006357
GO:0008270
GO:0010629
GO:0010803
GO:0016607
GO:0016740
GO:0016925
GO:0019789
GO:0033234
GO:0033235
GO:0043226
GO:0045671
GO:0045892
GO:0046872
GO:0060090
GO:0060255
GO:0061665
GO:0098978
GO:0099523
GO:0099524
GO:0140096
GO:0140110
HMNXSV003002144
ILMN_1814966
PH_hs_0028427
TC01001097.hg
g5174628_3p_a_at
Participates
as a member of
PIAS1,3 [nucleoplasm] (Homo sapiens)
PIAS2-2,PIAS3,PIAS4 [nucleoplasm] (Homo sapiens)
PIAS1,3,4 [nucleoplasm] (Homo sapiens)
as a candidate of
PIAS1,3 [nucleoplasm] (Homo sapiens)
Inferred To
Homologues of PIAS3 [nucleoplasm]
(Saccharomyces cerevisiae)
Su(var)2-10 [nucleoplasm]
(Drosophila melanogaster)
PIAS3 [nucleoplasm]
(Bos taurus)
PIAS3 [nucleoplasm]
(Caenorhabditis elegans)
PIAS3 [nucleoplasm]
(Gallus gallus)
PIAS3 [nucleoplasm]
(Mus musculus)
PIAS3 [nucleoplasm]
(Rattus norvegicus)
PIAS3 [nucleoplasm]
(Saccharomyces cerevisiae)
PIAS3 [nucleoplasm]
(Schizosaccharomyces pombe)
PIAS3 [nucleoplasm]
(Sus scrofa)
pias3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_006090.2
ENSEMBL
ENST00000393045
,
ENSP00000376765
OpenTargets
ENSG00000131788
HPA
ENSG00000131788-PIAS3
PRO
Q9Y6X2
Pharos - Targets
Q9Y6X2
PDB
4MVT
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UIS9 MBD1
2
MBD1 [nucleoplasm]
(R-HSA-417134)
monoSUMO1-K499,K538-MBD1 [nucleoplasm]
(R-HSA-4090331)
0.581
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.556
3
UniProt:Q8TAP4-4 LMO3
0.556
3
UniProt:Q15047-2 SETDB1
0.556
3
UniProt:P17252 PRKCA
8
PRKCA [cytosol]
(R-HSA-58196)
PRKCA [plasma membrane]
(R-HSA-156469)
pT497,T638,S657-PRKCA [plasma membrane]
(R-HSA-4332340)
p-T497,T638,S657-PRKCA [nucleoplasm]
(R-HSA-5223292)
p-T497-PRKCA [cytosol]
(R-HSA-5218731)
p-T497,T638,S657-PRKCA [cytosol]
(R-HSA-4332337)
PRKCA [photoreceptor disc membrane]
(R-HSA-2648987)
PRKCA [nucleoplasm]
(R-HSA-450530)
0.556
3
UniProt:O60664 PLIN3
7
p-PLIN3 [lysosomal lumen]
(R-HSA-9639396)
p-PLIN3 [cytosol]
(R-HSA-9613664)
p-PLIN3 [lipid droplet]
(R-HSA-9613539)
PLIN3 [lipid droplet]
(R-HSA-9613337)
p-PLIN3 [late endosome lumen]
(R-HSA-9639393)
PLIN3 [cytosol]
(R-HSA-6814628)
PLIN3 [transport vesicle]
(R-HSA-6813900)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
UBE2I [cytosol]
(R-HSA-4655342)
0.553
2
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