Reactome | PIAS2 [nucleoplasm]

PIAS2 [nucleoplasm]

Stable Identifier

R-HSA-2993787

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 SUMO-protein ligase PIAS2 ecNumber6.3.2.-/ecNumber, PIAS2_HUMAN, PIASx

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75928 PIAS2

Gene Names

PIAS2, PIASX

Chain

chain:1-621

Reference Genes

BioGPS Gene:9063 PIAS2

COSMIC (genes):PIAS2 PIAS2

CTD Gene:9063 PIAS2

dbSNP Gene:9063 PIAS2

ENSEMBL:ENSG00000078043 PIAS2

HGNC:17311 PIAS2

KEGG:hsa:9063 PIAS2

Monarch:9063 PIAS2

NCBI Gene:9063 PIAS2

OMIM:603567 PIAS2

UCSC:O75928 PIAS2

Reference Transcript

This entity regulates

Positively

HOXB1 gene is transcribed (Homo sapiens)

Cross References

RefSeq

NP_004662.2, NP_001310989.1, NP_775298.1

OpenTargets

ENSG00000078043

ENSEMBL

ENST00000585916, ENSG00000078043, ENSP00000465676, ENSP00000317163, ENST00000324794

HPA

ENSG00000078043-PIAS2

GeneCards

PIAS2

PRO

O75928

Pharos - Targets

O75928

GlyGen

O75928

PDB

4FO9, 2ASQ

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944)	0.853	8
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.782	8
UniProt:Q8IVL1 NAV2			0.666	4
UniProt:O95273 CCDB1			0.666	4
UniProt:Q96T51 RUFY1	3	p-Y389,400-RUFY1 [early endosome membrane] (R-HSA-5215951) RUFY1 [cytosol] (R-HSA-8871374) p-Y389,400-RUFY1 [cytosol] (R-HSA-8871352)	0.581	3
UniProt:Q96HD9 ACY3	1	ACY3 [cytosol] (R-HSA-5433065)	0.556	3
UniProt:Q96BR9 ZBT8A			0.556	3
UniProt:O43741 PRKAB2	3	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096) PRKAB2 [endoplasmic reticulum lumen] (R-HSA-9931271)	0.556	3
UniProt:P20592 MX2	1	MX2 [cytosol] (R-HSA-1015675)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q7KZS0 Q7KZS0			0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:Q969E8 TSR2			0.556	3
UniProt:Q59GP6 Q59GP6			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.519	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.499	4
UniProt:P0C206 REX			0.488	2

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