Transfer of SUMO2 from E1 to UBE2I (UBC9)

Stable Identifier
R-HSA-2993790
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SUMO2 is transferred from cysteine-173 of UBA2 to cysteine-93 of UBC9 (UBE2I) in a transthiolation reaction (Tatham et al. 2001, Werner et al. 2009).

Literature References
PubMed ID Title Journal Year
19107418 Performing in vitro sumoylation reactions using recombinant enzymes

Werner, A, Moutty, MC, Möller, U, Melchior, F

Methods Mol. Biol. 2009
11451954 Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9

Tatham, MH, Jaffray, E, Vaughan, OA, Desterro, JM, Botting, CH, Naismith, JH, Hay, RT

J. Biol. Chem. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of UBA2:SAE1 [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created