COX10 transforms heme to heme O

Stable Identifier
R-HSA-2995330
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix, mitochondrial inner membrane
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COX10 transforms heme to heme O
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Heme O and heme A are specifically synthesised for the heme-copper respiratory oxidases. Mitochondrial protoheme IX farnesyltransferase (COX10) mediates the transformation of protoheme IX (heme) and farnesyl diphosphate (FAPP) to heme O (Glerum & Tzagoloff 1994). COX10 is highly expressed in muscle, heart and brain (Murakami et al. 1997).

Literature References
PubMed ID Title Journal Year
8078902 Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant

Glerum, DM, Tzagoloff, A

Proc. Natl. Acad. Sci. U.S.A. 1994
9177788 Genomic structure and expression of the human heme A:farnesyltransferase (COX10) gene

Murakami, T, Reiter, LT, Lupski, JR

Genomics 1997
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protoheme IX farnesyltransferase activity of COX10(?-443) [mitochondrial inner membrane]
Physical Entity
COX10(?-443) [mitochondrial inner membrane]
Activity
protoheme IX farnesyltransferase activity (0008495)
Orthologous Events
COX10 transforms heme to heme O (Bos taurus)
COX10 transforms heme to heme O (Caenorhabditis elegans)
COX10 transforms heme to heme O (Canis familiaris)
COX10 transforms heme to heme O (Dictyostelium discoideum)
COX10 transforms heme to heme O (Drosophila melanogaster)
COX10 transforms heme to heme O (Gallus gallus)
COX10 transforms heme to heme O (Mus musculus)
COX10 transforms heme to heme O (Plasmodium falciparum)
COX10 transforms heme to heme O (Rattus norvegicus)
COX10 transforms heme to heme O (Saccharomyces cerevisiae)
COX10 transforms heme to heme O (Schizosaccharomyces pombe)
COX10 transforms heme to heme O (Sus scrofa)
COX10 transforms heme to heme O (Xenopus tropicalis)
Authored
Jassal, B  (2013-01-22)
Reviewed
D'Eustachio, P  (2013-04-15)
Created
Jassal, B  (2013-01-22)