COX10 transforms heme to heme O

Stable Identifier
R-HSA-2995330
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Heme O and heme A are specifically synthesised for the heme-copper respiratory oxidases. Mitochondrial protoheme IX farnesyltransferase (COX10) mediates the transformation of protoheme IX (heme) and farnesyl diphosphate (FAPP) to heme O (Glerum & Tzagoloff 1994). COX10 is highly expressed in muscle, heart and brain (Murakami et al. 1997).

Literature References
PubMed ID Title Journal Year
8078902 Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant

Glerum, DM, Tzagoloff, A

Proc. Natl. Acad. Sci. U.S.A. 1994
9177788 Genomic structure and expression of the human heme A:farnesyltransferase (COX10) gene

Murakami, T, Reiter, LT, Lupski, JR

Genomics 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protoheme IX farnesyltransferase activity of COX10(?-443) [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created