Reactome | VRK1 [cytosol]

VRK1 [cytosol]

Stable Identifier

R-HSA-2995381

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Serine/threonine-protein kinase VRK1, Vaccinia-related kinase 1

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
        
        ANKLE2 binds VRK1,(VRK2) (Homo sapiens)
        
        ANKLE2:VRK1/VRK2 [endoplasmic reticulum membrane] (Homo sapiens)
        
        VRK1,(VRK2) [cytosol] (Homo sapiens)
        
        VRK1 [cytosol] (Homo sapiens)
        
        VRK1,(VRK2) [cytosol] (Homo sapiens)
        
        VRK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99986 VRK1

Gene Names

VRK1

Chain

chain:1-396

Reference Genes

BioGPS Gene:7443 VRK1

COSMIC (genes):VRK1 VRK1

CTD Gene:7443 VRK1

dbSNP Gene:7443 VRK1

ENSEMBL:ENSG00000100749 VRK1

HGNC:12718 VRK1

KEGG:hsa:7443 VRK1

Monarch:7443 VRK1

NCBI Gene:7443 VRK1

OMIM:602168 VRK1

UCSC:Q99986 VRK1

Reference Transcript

RefSeq:NM_003384.2 VRK1

Other Identifiers

11743536_at

16788142

203856_PM_at

203856_at

241737_PM_x_at

241737_x_at

2565176

3550526

3550527

3550528

3550529

3550530

3550536

3550537

3550538

3550540

3550541

3550542

3550543

3550544

3550545

3550546

3550547

3550548

3550550

3550551

3550552

3550553

3550554

3550555

3550556

3550557

3550558

3550562

3550563

3550564

3550565

3550566

3550574

3550575

3550576

3550577

3550578

3550579

3550580

3550581

3550583

3550584

3550587

3550588

3550589

3550590

3550591

3550592

39980_at

59179_at

7443

7894573

7976621

90364_at

AB000449_at

A_14_P125646

A_14_P139143

A_23_P76761

A_33_P3304824

GE53012

GE712859

GE778666

GE85181

GE900386

GO:0000785

GO:0003677

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005795

GO:0005829

GO:0006325

GO:0006338

GO:0006468

GO:0006974

GO:0007077

GO:0007165

GO:0015030

GO:0016020

GO:0016301

GO:0016740

GO:0019901

GO:0030576

GO:0031175

GO:0031492

GO:0035175

GO:0042393

GO:0043226

GO:0046777

GO:0051301

GO:0061024

GO:0072354

GO:0090166

GO:0106310

GO:0120187

GO:0140096

GO:0141003

GO:2001222

HMNXSV003040412

HMNXSV003043699

HMNXSV003053828

Hs.138777.0.A1_3p_at

ILMN_1805828

PH_hs_0025158

TC14000608.hg

TC14000609.hg

g4507902_3p_at

p29110

p4966

Participates

as a member of

VRK1,(VRK2) [cytosol] (Homo sapiens)

Other forms of this molecule

VRK1 [nucleoplasm]

Inferred To

Homologues of VRK1 [cytosol] (Drosophila melanogaster)

VRK1 [cytosol] (Bos taurus)

VRK1 [cytosol] (Caenorhabditis elegans)

VRK1 [cytosol] (Canis familiaris)

VRK1 [cytosol] (Danio rerio)

VRK1 [cytosol] (Drosophila melanogaster)

VRK1 [cytosol] (Gallus gallus)

VRK1 [cytosol] (Mus musculus)

VRK1 [cytosol] (Rattus norvegicus)

VRK1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_003375.1

Guide to Pharmacology - Targets

2275

OpenTargets

ENSG00000100749

ENSEMBL

ENSP00000506151, ENSP00000216639, ENSP00000506525, ENST00000679816, ENST00000680756, ENSP00000506214, ENST00000216639, ENSP00000506648, ENST00000681355, ENST00000681344

ZINC - Substances

VRK1_HUMAN

ZINC target

Q99986

PRO

Q99986

GlyGen

Q99986

PDB

2LAV, 2KTY, 6CSW, 5UVF, 6AC9, 7TAN, 3OP5, 6BU6, 5UKF, 6CQH, 6CFM, 6BP0, 6CMM, 2KUL, 2RSV, 6VXU, 6CNX, 6NPN, 6BRU, 7M10, 8F8Y, 6BTW, 6VZH, 6DD4

HPA

ENSG00000100749-VRK1

Pharos - Targets

Q99986

Orphanet

VRK1

HMDB Protein

HMDBP01270

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.761	11
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.675	5
UniProt:O60934 NBN	3	p-S343-NBN [nucleoplasm] (R-HSA-75237) NBN [cytosol] (R-HSA-5684005) NBN [nucleoplasm] (R-HSA-75163)	0.65	13
UniProt:Q96GD4 AURKB	3	AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360) polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414)	0.65	14
UniProt:Q9H4B4 PLK3	1	PLK3 [nucleoplasm] (R-HSA-3222161)	0.65	12
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.645	6
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.61	14
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.602	8
UniProt:P15336 ATF2	2	p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243) ATF2 [nucleoplasm] (R-HSA-450336)	0.571	5
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.544	3
UniProt:P02675 FGB	5	FGB [extracellular region] (R-HSA-140584) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [plasma membrane] (R-HSA-140917) FGB(31-491) [extracellular region] (R-HSA-140846) FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:P04798 CYP1A1	1	CYP1A1 [endoplasmic reticulum membrane] (R-HSA-52623)	0.527	2

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