PP2A dephosphorylates BANF1

Stable Identifier
R-HSA-2995388
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SVG |   | PPTX  | SBGN
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The PP2A complex that contains the regulatory subunit B55-alpha (PPP2R2A) is the only phosphatase essential for mitotic exit (Schmitz et al. 2010). The PP2A complex is necessary for BANF1 (BAF) dephosphorylation in late mitotic anaphase. ANKLE2 (LEM4) binds the PP2A complex that contains the B55-alpha regulatory subunit and facilitates BANF1 dephosphorylation, but as ANKLE2 does not interact with BANF1 (BAF) directly, the exact mechanism has not been determined (Asencio et al. 2012).

Literature References
PubMed ID Title Journal Year
22770216 Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis

Asencio, C, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Mall, M, Wallenfang, MR, Mattaj, IW, Gorjánácz, M

Cell 2012
20711181 Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

Schmitz, MH, Held, M, Janssens, V, Hutchins, JR, Hudecz, O, Ivanova, E, Goris, J, Trinkle-Mulcahy, L, Lamond, AI, Poser, I, Hyman, AA, Mechtler, K, Peters, JM, Gerlich, DW

Nat. Cell Biol. 2010
Participants
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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine phosphatase activity of PP2A (Aalpha:B55alpha:Calpha) [cytosol]
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Activity
This event is regulated
Orthologous Events
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Created