ANKLE2 binds VRK1 or VRK2

Stable Identifier
R-HSA-2995389
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ANKLE2 (LEM4) is required for nuclear envelope formation in C. elegans and its function appears to be conserved in human cells. Both human LEM4 and the C. elegans ortholog bind VRK1 (and possibly VRK2), the kinase responsible for phosphorylation of BANF1 (BAF) in mitotic prophase, and inhibit VRK1 catalytic activity (Asencio et al. 2012).

Literature References
PubMed ID Title Journal Year
22770216 Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis

Asencio, C, Davidson, IF, Santarella-Mellwig, R, Ly-Hartig, TB, Mall, M, Wallenfang, MR, Mattaj, IW, Gorjánácz, M

Cell 2012
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created