Reactome | GNAO1 [plasma membrane]

GNAO1 [plasma membrane]

Stable Identifier

R-HSA-2997536

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Guanine nucleotide-binding protein G alpha (o), GNAO_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein activation (Homo sapiens)
        
        G-protein alpha subunit is inactivated (Homo sapiens)
        
        G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        G-protein alpha:GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        G-protein beta-gamma subunits rebind the alpha-GDP subunit (Homo sapiens)
        
        G protein-GDP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha:GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        G-protein alpha:GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        The high affinity receptor complex binds to G-protein (Homo sapiens)
        
        G protein-GDP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha:GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        Opioid:MOR:G protein-GDP complex [plasma membrane] (Homo sapiens)
        
        G protein-GDP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha:GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        The receptor:G-protein complex binds GTP (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        Opioid:MOR:G protein-GTP complex [plasma membrane] (Homo sapiens)
        
        G protein-GTP [plasma membrane] (Homo sapiens)
        
        G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        The receptor:G-protein complex dissociates (Homo sapiens)
        
        G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        Opioid:MOR:G protein-GTP complex [plasma membrane] (Homo sapiens)
        
        G protein-GTP [plasma membrane] (Homo sapiens)
        
        G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        The receptor:G-protein complex releases GDP (Homo sapiens)
        
        Opioid:MOR:G protein-GDP complex [plasma membrane] (Homo sapiens)
        
        G protein-GDP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha:GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Activation of PLC beta-1/4 (Homo sapiens)
        
        Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
        
        G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        Inactivation of PLC beta (Homo sapiens)
        
        Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
        
        G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        G-protein alpha:GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        PIP2 hydrolysis (Homo sapiens)
        
        Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
        
        G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
        
        G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - Beta-catenin independent WNT signaling (Homo sapiens)
    - Ca2+ pathway (Homo sapiens)
      - FZD recruits trimeric G-proteins (Homo sapiens)
        
        Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
      - G-protein subunits dissociate from WNT:FZD complex (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2):GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
      - WNT:FZD complex promotes G-protein nucleotide exchange (Homo sapiens)
        
        WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2):GTP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)
        
        WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2):GDP [plasma membrane] (Homo sapiens)
        
        G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
        
        GNAO1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09471 GNAO1

Gene Names

GNAO1

Chain

initiator methionine:1, chain:2-354

Reference Genes

BioGPS Gene:2775 GNAO1

COSMIC (genes):GNAO1 GNAO1

CTD Gene:2775 GNAO1

dbSNP Gene:2775 GNAO1

ENSEMBL:ENSG00000087258 GNAO1

HGNC:4389 GNAO1

KEGG Gene (Homo sapiens):2775 GNAO1

Monarch:2775 GNAO1

NCBI Gene:2775 GNAO1

OMIM:139311 GNAO1

UCSC:P09471 GNAO1

Reference Transcript

Other Identifiers

0001990324

11733813_a_at

11733814_a_at

11742976_at

11742977_a_at

11756528_x_at

16819161

204762_s_at

204763_s_at

215912_at

231951_at

236_at

2775

34138_at

34698_at

3661941

3661942

3661943

3661944

3661945

3661947

3661981

3661997

3661999

3662001

3662009

3662010

3662011

3662012

3662013

3662015

3662016

3662017

3662018

69489_at

7995739

90648_at

91782_f_at

91785_r_at

A_14_P108997

A_23_P26582

A_24_P393611

A_24_P936145

A_33_P3404814

GE57855

GE80588

GO:0000166

GO:0001664

GO:0003013

GO:0003674

GO:0003924

GO:0005102

GO:0005525

GO:0005575

GO:0005622

GO:0005834

GO:0005886

GO:0006457

GO:0006810

GO:0006936

GO:0006950

GO:0007165

GO:0007186

GO:0007188

GO:0007212

GO:0007223

GO:0007267

GO:0007568

GO:0007626

GO:0008016

GO:0008150

GO:0009987

GO:0010243

GO:0014070

GO:0016020

GO:0019001

GO:0030154

GO:0030425

GO:0030900

GO:0031175

GO:0031683

GO:0031821

GO:0031852

GO:0032794

GO:0032991

GO:0034097

GO:0042475

GO:0042493

GO:0042542

GO:0043005

GO:0043167

GO:0043209

GO:0043278

GO:0043547

GO:0044297

GO:0044877

GO:0046872

GO:0048856

GO:0051430

GO:0051926

Hs.198511.0.S1_3p_at

Hs.296184.0.S1_3p_a_at

Hs.296184.0.S1_3p_s_at

Hs.296184.1.S1_3p_at

ILMN_1742704

ILMN_1800381

M60165_cds1_at

PH_hs_0023187

PH_hs_0035715

TC16000461.hg

TC16001574.hg

g10567815_3p_a_at

Participant Of

hasMember

Inferred To

GNAO1 [plasma membrane] (Canis familiaris)

GNAO1 [plasma membrane] (Danio rerio)

GNAO1 [plasma membrane] (Gallus gallus)

GNAO1 [plasma membrane] (Sus scrofa)

goa-1 [plasma membrane] (Caenorhabditis elegans)

gpa2 [plasma membrane] (Schizosaccharomyces pombe)

gnao1 [plasma membrane] (Xenopus tropicalis)

GPA1 [plasma membrane] (Saccharomyces cerevisiae)

Gnao1 [plasma membrane] (Mus musculus)

Gnao1 [plasma membrane] (Rattus norvegicus)

gpa1 [plasma membrane] (Schizosaccharomyces pombe)

Homologues of GNAO1 [plasma membrane] (Danio rerio)

Homologues of GNAO1 [plasma membrane] (Schizosaccharomyces pombe)

gnao1a [plasma membrane] (Danio rerio)

gpaA [plasma membrane] (Dictyostelium discoideum)

Galphao [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_620073.2, NP_066268.1

OpenTargets

ENSG00000087258

HPA

ENSG00000087258-GNAO1

GeneCards

P09471

ZINC target

P09471

Ensembl

ENSP00000262493, ENST00000262493, ENST00000262494, ENST00000638705, ENSG00000087258, ENSP00000262494, ENSP00000491223

PRO

P09471

Orphanet

22304

HMDB Protein

HMDBP11470

PDB

6K41, 6WWZ, 6OIK, 6G79, 6FUF

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [cytosol] (R-HSA-1181251)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128fs3 [cytosol] (R-HSA-3642173) TGFBR2 K128fs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:P45973 CBX5	2	SUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849) CBX5 [nucleoplasm] (R-HSA-994093)	0.556	3

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