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GNAO1 [plasma membrane]
Stable Identifier
R-HSA-2997536
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Guanine nucleotide-binding protein G alpha (o), GNAO_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
G-protein alpha releases G-protein heterotrimer from PDCL (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
G-protein heterotrimer [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein activation (Homo sapiens)
G-protein alpha subunit is inactivated (Homo sapiens)
G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
G-protein alpha:GDP [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
G-protein beta-gamma subunits rebind the alpha-GDP subunit (Homo sapiens)
G protein-GDP complex [plasma membrane] (Homo sapiens)
G-protein alpha:GDP [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
G-protein alpha:GDP [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
The high affinity receptor complex binds to G-protein (Homo sapiens)
G protein-GDP complex [plasma membrane] (Homo sapiens)
G-protein alpha:GDP [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
Opioid:MOR:G protein-GDP complex [plasma membrane] (Homo sapiens)
G protein-GDP complex [plasma membrane] (Homo sapiens)
G-protein alpha:GDP [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
The receptor:G-protein complex binds GTP (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
Opioid:MOR:G protein-GTP complex [plasma membrane] (Homo sapiens)
G protein-GTP [plasma membrane] (Homo sapiens)
G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
The receptor:G-protein complex dissociates (Homo sapiens)
G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
Opioid:MOR:G protein-GTP complex [plasma membrane] (Homo sapiens)
G protein-GTP [plasma membrane] (Homo sapiens)
G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
The receptor:G-protein complex releases GDP (Homo sapiens)
Opioid:MOR:G protein-GDP complex [plasma membrane] (Homo sapiens)
G protein-GDP complex [plasma membrane] (Homo sapiens)
G-protein alpha:GDP [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
Activation of PLC beta-1/4 (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
Inactivation of PLC beta (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
G-protein alpha:GDP [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
PIP2 hydrolysis (Homo sapiens)
Activated PLC beta 1/4 [plasma membrane] (Homo sapiens)
G protein alpha:GTP complex [plasma membrane] (Homo sapiens)
G-protein alpha (i/o/z/t) subunit [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
FZD recruits trimeric G-proteins (Homo sapiens)
Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (o/t2):GDP [plasma membrane] (Homo sapiens)
G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (o/t2):GDP [plasma membrane] (Homo sapiens)
G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
G-protein subunits dissociate from WNT:FZD complex (Homo sapiens)
G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Homo sapiens)
G-protein alpha (o/t2):GTP [plasma membrane] (Homo sapiens)
G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
WNT:FZD complex promotes G-protein nucleotide exchange (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) active [plasma membrane] (Homo sapiens)
G-protein alpha (o/t2):GTP [plasma membrane] (Homo sapiens)
G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
WNT5A/11:FZD:G-protein (alpha o/t2) inactive [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein (o/t2) (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (o/t2):GDP [plasma membrane] (Homo sapiens)
G-protein alpha (o/t2) [plasma membrane] (Homo sapiens)
GNAO1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09471 GNAO1
Gene Names
GNAO1
Chain
initiator methionine:1, chain:2-354
Reference Genes
BioGPS Gene:2775 GNAO1
COSMIC (genes):GNAO1 GNAO1
CTD Gene:2775 GNAO1
dbSNP Gene:2775 GNAO1
ENSEMBL:ENSG00000087258 GNAO1
HGNC:4389 GNAO1
KEGG Gene (Homo sapiens):2775 GNAO1
Monarch:2775 GNAO1
NCBI Gene:2775 GNAO1
OMIM:139311 GNAO1
UCSC:P09471 GNAO1
Reference Transcript
RefSeq:NM_138736.2 GNAO1
RefSeq:NM_020988.2 GNAO1
Other Identifiers
0001990324
11733813_a_at
11733814_a_at
11742976_at
11742977_a_at
11756528_x_at
16819161
204762_s_at
204763_s_at
215912_at
231951_at
236_at
2775
34138_at
34698_at
3661941
3661942
3661943
3661944
3661945
3661947
3661981
3661997
3661999
3662001
3662009
3662010
3662011
3662012
3662013
3662015
3662016
3662017
3662018
69489_at
7995739
90648_at
91782_f_at
91785_r_at
A_14_P108997
A_23_P26582
A_24_P393611
A_24_P936145
A_33_P3404814
GE57855
GE80588
GO:0000166
GO:0001664
GO:0003013
GO:0003674
GO:0003924
GO:0005102
GO:0005525
GO:0005575
GO:0005622
GO:0005834
GO:0005886
GO:0006457
GO:0006810
GO:0006936
GO:0006950
GO:0007165
GO:0007186
GO:0007188
GO:0007212
GO:0007223
GO:0007267
GO:0007568
GO:0007626
GO:0008016
GO:0008150
GO:0009987
GO:0010243
GO:0014070
GO:0016020
GO:0019001
GO:0030154
GO:0030425
GO:0030900
GO:0031175
GO:0031683
GO:0031821
GO:0031852
GO:0032794
GO:0032991
GO:0034097
GO:0042475
GO:0042493
GO:0042542
GO:0043005
GO:0043167
GO:0043209
GO:0043278
GO:0043547
GO:0044297
GO:0044877
GO:0046872
GO:0048856
GO:0051430
GO:0051926
Hs.198511.0.S1_3p_at
Hs.296184.0.S1_3p_a_at
Hs.296184.0.S1_3p_s_at
Hs.296184.1.S1_3p_at
ILMN_1742704
ILMN_1800381
M60165_cds1_at
PH_hs_0023187
PH_hs_0035715
TC16000461.hg
TC16001574.hg
g10567815_3p_a_at
Participant Of
hasMember
G-protein alpha (i/o/z/t) subunit [plasma membrane]
G-protein alpha (o/t2) [plasma membrane]
Inferred To
GNAO1 [plasma membrane] (Canis familiaris)
GNAO1 [plasma membrane] (Danio rerio)
GNAO1 [plasma membrane] (Gallus gallus)
GNAO1 [plasma membrane] (Sus scrofa)
goa-1 [plasma membrane] (Caenorhabditis elegans)
gpa2 [plasma membrane] (Schizosaccharomyces pombe)
gnao1 [plasma membrane] (Xenopus tropicalis)
GPA1 [plasma membrane] (Saccharomyces cerevisiae)
Gnao1 [plasma membrane] (Mus musculus)
Gnao1 [plasma membrane] (Rattus norvegicus)
gpa1 [plasma membrane] (Schizosaccharomyces pombe)
Homologues of GNAO1 [plasma membrane] (Danio rerio)
Homologues of GNAO1 [plasma membrane] (Schizosaccharomyces pombe)
gnao1a [plasma membrane] (Danio rerio)
gpaA [plasma membrane] (Dictyostelium discoideum)
Galphao [plasma membrane] (Drosophila melanogaster)
Cross References
RefSeq
NP_620073.2
,
NP_066268.1
OpenTargets
ENSG00000087258
HPA
ENSG00000087258-GNAO1
GeneCards
P09471
ZINC target
P09471
Ensembl
ENSP00000262493
,
ENST00000262493
,
ENST00000262494
,
ENST00000638705
,
ENSG00000087258
,
ENSP00000262494
,
ENSP00000491223
PRO
P09471
Orphanet
22304
HMDB Protein
HMDBP11470
PDB
6K41
,
6WWZ
,
6OIK
,
6G79
,
6FUF
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
7
UniProt:P55072 VCP
8
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [cytosol]
(R-HSA-1181251)
0.556
3
UniProt:P27797 CALR
6
CALR [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128fs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128fs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:P45973 CBX5
2
SUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
CBX5 [nucleoplasm]
(R-HSA-994093)
0.556
3
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