Reactome | monoSUMO1-K-TP53BP1 [nucleoplasm]

monoSUMO1-K-TP53BP1 [nucleoplasm]

Stable Identifier

R-HSA-2997591

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO1 N-glycyl-lys TP53BP1, Tumor suppressor p53-binding protein 1, TP53B_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
20016603	Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks Jackson, SP, Polo, S, Coates, J, Miller, KM, Galanty, Y, Belotserkovskaya, R	Nature	2009

External Reference Information

External Reference

UniProt:Q12888 TP53BP1

Gene Names

TP53BP1

Chain

chain:1-1972

Reference Genes

BioGPS Gene:7158 TP53BP1

COSMIC (genes):TP53BP1 TP53BP1

CTD Gene:7158 TP53BP1

dbSNP Gene:7158 TP53BP1

ENSEMBL:ENSG00000067369 TP53BP1

ENSEMBL_homo_sapiens_GENE:ENSG00000067369.14 TP53BP1

HGNC:11999 TP53BP1

KEGG Gene (Homo sapiens):7158 TP53BP1

Monarch:7158 TP53BP1

NCBI Gene:7158 TP53BP1

OMIM:605230 TP53BP1

UCSC:Q12888 TP53BP1

Reference Transcript

Other Identifiers

11718808_a_at

11735724_a_at

11735725_x_at

1569097_PM_at

1569097_at

1569098_PM_s_at

1569098_s_at

16808109

1711_at

203050_PM_at

203050_at

213266_PM_at

213266_at

3621190

3621191

3621193

3621195

3621196

3621197

3621198

3621200

3621202

3621203

3621206

3621208

3621209

3621212

3621213

3621214

3621218

3621219

3621220

3621222

3621223

3621225

3621227

3621230

3621234

3621235

3621236

3621237

3621238

3621240

3621241

3621242

3621244

3621245

3621246

3621248

3621250

3621251

3621252

3621255

3621256

3621257

3621259

3621260

3621263

40986_s_at

7158

78028_at

7988093

A_23_P88703

A_32_P118978

GE54711

GO:0000077

GO:0000775

GO:0000776

GO:0000781

GO:0002039

GO:0002376

GO:0003677

GO:0003684

GO:0003712

GO:0005515

GO:0005634

GO:0005654

GO:0005657

GO:0005694

GO:0005737

GO:0006281

GO:0006303

GO:0006310

GO:0006325

GO:0006351

GO:0006355

GO:0006974

GO:0016604

GO:0023052

GO:0035064

GO:0035861

GO:0042162

GO:0042393

GO:0043226

GO:0043565

GO:0045830

GO:0045893

GO:0045944

GO:0048856

GO:0051091

GO:0051260

GO:0060090

GO:0061629

GO:0061649

GO:0065003

GO:0071481

GO:0097680

GO:0140110

GO:0140566

GO:1990391

GO:2000042

HMNXSV003044702

HMNXSV003051954

Hs.20621.1.A1_3p_at

Hs2.407233.1.S1_3p_s_at

ILMN_1664440

PH_hs_0025822

TC15001278.hg

TC15002510.hg

U09477_at

g5032188_3p_at

Participates

as an output of

PIAS4 SUMOylates TP53BP1 with SUMO1 (Homo sapiens)

Other forms of this molecule

p-S25,S1778-TP53BP1 [nucleoplasm]

TP53BP1 [nucleoplasm]

Inferred To

TP53BP1 [nucleoplasm] (Bos taurus)

TP53BP1 [nucleoplasm] (Sus scrofa)

crb2 [nucleoplasm] (Schizosaccharomyces pombe)

RAD9 [nucleoplasm] (Saccharomyces cerevisiae)

tp53bp1 [nucleoplasm] (Xenopus tropicalis)

Tp53bp1 [nucleoplasm] (Mus musculus)

Tp53bp1 [nucleoplasm] (Rattus norvegicus)

monoSUMO1-K-TP53BP1 [nucleoplasm] (Dictyostelium discoideum)

monoSUMO1-K-TP53BP1 [nucleoplasm] (Gallus gallus)

hsr-9 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at unknown position

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_005648.1, NP_001135452.1, NP_001135451.1

OpenTargets

ENSG00000067369

ZINC - Substances

TP53B_HUMAN

GeneCards

Q12888

HPA

ENSG00000067369-TP53BP1

ZINC target

Q12888

Ensembl

ENST00000382044, ENSP00000393497, ENSG00000067369, ENST00000450115, ENSP00000371475, ENSP00000263801, ENST00000263801

PRO

Q12888

Pharos - Targets

Q12888

ZINC - Predictions - Purchasable

TP53B_HUMAN

PDB

2G3R, 6MXZ, 1GZH, 5ECG, 6MY0, 2MWP, 6MXY, 3LH0, 8EOM, 6IUA, 6VIP, 2IG0, 6RMM, 8U4U, 7YQK, 6VA5, 5KGF, 4RG2, 2LVM, 5Z78, 3LGF, 7LIN, 6CO2, 4CRI, 1KZY, 8HKW, 6CO1, 7LIO, 6MXX, 2MWO, 3LGL, 6RML, 5ZCJ, 8F0W, 6IU7, 4X34, 5J26, 8SWJ, 6UPT, 1XNI

Interactors (63)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.87	14
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.87	8
UniProt:P16104 H2AFX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583)	0.793	6
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.718	6
UniProt:P53350 PLK1	4	PLK1 [nucleoplasm] (R-HSA-156720) p-T210-PLK1 [cytosol] (R-HSA-3000318) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) PLK1 [cytosol] (R-HSA-164603)	0.718	6
UniProt:Q6NZQ4 Paxip1	2	Paxip1 [nucleoplasm] (R-MMU-5619398) Paxip1 [nucleoplasm] (R-MMU-5619395)	0.708	5
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.7	5
UniProt:P0C0S8 H2AC11	11	K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) HIST1H2AG [nucleoplasm] (R-HSA-212084) Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311)	0.672	21
UniProt:Q6ZW49 PAXIP1	1	PAXIP1 [nucleoplasm] (R-HSA-5619395)	0.656	5
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.655	5
UniProt:P63167 DYNLL1	6	DYNLL1 [ciliary tip] (R-HSA-5625335) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [cytosol] (R-HSA-387105)	0.643	3
UniProt:Q99986 VRK1	2	VRK1 [nucleoplasm] (R-HSA-2528998) VRK1 [cytosol] (R-HSA-2995381)	0.602	8
UniProt:Q13315 ATM	5	Ac-K3016-ATM [nucleoplasm] (R-HSA-5682043) ATM [nucleoplasm] (R-HSA-69484) p-S1981,Ac-K3016-ATM [nucleoplasm] (R-HSA-5693527) ATM [peroxisomal matrix] (R-HSA-9665169) ATM [cytosol] (R-HSA-9665171)	0.571	2
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P23763-3 VAMP1			0.556	3
UniProt:P50570-2 DNM2			0.556	3
UniProt:Q5SWW7 CJ055			0.556	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
IntAct:EBI-25857482 CCSB			0.556	3
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.556	3
UniProt:Q13393 PLD1	4	PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [tertiary granule membrane] (R-HSA-6800955) PLD1 [specific granule membrane] (R-HSA-6799531)	0.556	3
UniProt:Q02930-3 CREB5			0.556	3
UniProt:P61086 UBE2K	2	UBE2K [cytosol] (R-HSA-934631) Ub-C92-UBE2K [cytosol] (R-HSA-8864200)	0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:Q5T6F2 UBAP2			0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [platelet alpha granule membrane] (R-HSA-61489) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:P13637 ATP1A3	1	ATP1A3 [plasma membrane] (R-HSA-936803)	0.556	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.556	3
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171)	0.556	3
UniProt:Q49AR9 Q49AR9			0.556	3
UniProt:P78424 PO6F2			0.556	3
UniProt:Q96G42 KLD7B			0.556	3
UniProt:O43711 TLX3			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:P04275-2 P042752			0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P78337 PITX1			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:O75190-2 DNAJB6			0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:Q14676 MDC1	6	monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) MDC1 [nucleoplasm] (R-HSA-75231)	0.548	4
UniProt:P62807 H2BC4	9	Ub-HIST1H2BC [nucleoplasm] (R-HSA-6782552) AcK-HIST1H2BC [nucleoplasm] (R-HSA-4549246) HIST1H2BC [extracellular region] (R-HSA-977564) AcK16-HIST1H2BC [nucleoplasm] (R-HSA-4568634) AcK6-HIST1H2BC [nucleoplasm] (R-HSA-4568623) AcK13-HIST1H2BC [nucleoplasm] (R-HSA-4568620) AcK21-HIST1H2BC [nucleoplasm] (R-HSA-4568626) Ub-121-HIST1H2BC [nucleoplasm] (R-HSA-3364029) HIST1H2BC [nucleoplasm] (R-HSA-181906)	0.544	6
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.536	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.536	2
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.536	2
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.527	2
UniProt:O43257 ZNHI1			0.524	2
UniProt:Q9UMN6 KMT2B	5	KMT2B [cytosol] (R-HSA-9818624) KMT2B(2-2062) [cytosol] (R-HSA-9818621) KMT2B(2063-2715) [cytosol] (R-HSA-9818626) KMT2B(2063-2715) [nucleoplasm] (R-HSA-9818623) KMT2B(2-2062) [nucleoplasm] (R-HSA-9818620)	0.524	2
UniProt:Q8NAV1 PRPF38A	1	PRPF38A [nucleoplasm] (R-HSA-8867897)	0.508	2
UniProt:Q86V20-2 SHLD2			0.499	3
UniProt:Q14686 NCOA6	1	NCOA6 [nucleoplasm] (R-HSA-376414)	0.499	3
UniProt:Q96SB8 SMC6	1	SMC6 [nucleoplasm] (R-HSA-2993777)	0.483	2
UniProt:Q96RU2 USP28	1	USP28 [nucleoplasm] (R-HSA-3215039)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7
UniProt:Q71F56 MED13L	1	MED13L [nucleoplasm] (R-HSA-556797)	0.483	2

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