PIAS1,4 SUMOylates BRCA1 with SUMO2,3

Stable Identifier
R-HSA-2997616
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO2,3 to BRCA1
Locations in the PathwayBrowser
Summation

PIAS1,4 SUMOylate BRCA1 with SUMO2,3 (Galanty et al. 2009, Morris et al. 2009, Vialter et al. 2011, Hendriks et al. 2014). More SUMO2,3-BRCA1 than SUMO1-BRCA1 is observed in vivo (Morris et al. 2009, Galanty et al. 2009). SUMOylation with SUMO2,3 increases in response to oxidative stress (Vialter et al. 2011). SUMOylation of BRCA1 increases its ubiquitin ligase activity (Morris et al. 2009).

Literature References
PubMed ID Title Journal Year
20016594 The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

Morris, JR, Boutell, C, Keppler, M, Densham, R, Weekes, D, Alamshah, A, Butler, L, Galanty, Y, Pangon, L, Kiuchi, T, Ng, T, Solomon, E

Nature 2009
20016603 Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

Galanty, Y, Belotserkovskaya, R, Coates, J, Polo, S, Miller, KM, Jackson, SP

Nature 2009
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
21147198 Cell cycle-dependent conjugation of endogenous BRCA1 protein with SUMO-2/3

Vialter, A, Vincent, A, Demidem, A, Morvan, D, Stepien, G, Venezia, ND, Rio, PG

Biochim. Biophys. Acta 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1,4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed