Reactome: A Curated Pathway Database

PIAS1,4 SUMOylates BRCA1 with SUMO2,3

Stable Identifier
R-HSA-2997616
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO2,3 to BRCA1
Locations in the PathwayBrowser
Summation

PIAS1,4 SUMOylate BRCA1 with SUMO2,3 (Galanty et al. 2009, Morris et al. 2009, Vialter et al. 2011, Hendriks et al. 2014). More SUMO2,3-BRCA1 than SUMO1-BRCA1 is observed in vivo (Morris et al. 2009, Galanty et al. 2009). SUMOylation with SUMO2,3 increases in response to oxidative stress (Vialter et al. 2011). SUMOylation of BRCA1 increases its ubiquitin ligase activity (Morris et al. 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of PIAS1,4 [nucleoplasm] PIAS1,4 [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events