Reactome: A Curated Pathway Database

PIAS1,4 SUMOylates BRCA1 with SUMO1

Stable Identifier
R-HSA-2997709
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO1 to BRCA1
Locations in the PathwayBrowser
Summation

PIAS1,4 SUMOylate BRCA1 with SUMO1 at lysine-109 (Morris et al. 2009, Xu et al. 2009). SUMOylation occurs in response to genotoxic stress and double-strand breaks to which PIAS1 and PIAS4 are recruited (Galanty et al. 2009). SUMOylation enhances the ability of BRCA1 to bind and modulate ESR1 (ERalpha) transcriptional activity (Xu et al. 2009). More SUMO2:BRCA1 than SUMO1:BRCA1 is observed in vivo (Morris et al. 2009, Galanty et al. 2009).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of PIAS1,4 [nucleoplasm] PIAS1,4 [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events