PIAS1,4 SUMOylates BRCA1 with SUMO1

Stable Identifier
Reaction [transition]
Homo sapiens
Conjugation of SUMO1 to BRCA1
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PIAS1,4 SUMOylate BRCA1 with SUMO1 at lysine-109 (Morris et al. 2009, Xu et al. 2009). SUMOylation occurs in response to genotoxic stress and double-strand breaks to which PIAS1 and PIAS4 are recruited (Galanty et al. 2009). SUMOylation enhances the ability of BRCA1 to bind and modulate ESR1 (ERalpha) transcriptional activity (Xu et al. 2009). More SUMO2:BRCA1 than SUMO1:BRCA1 is observed in vivo (Morris et al. 2009, Galanty et al. 2009).

Literature References
PubMed ID Title Journal Year
20016603 Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

Jackson, SP, Polo, S, Coates, J, Miller, KM, Galanty, Y, Belotserkovskaya, R

Nature 2009
20016594 The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress

Morris, JR, Keppler, M, Solomon, E, Alamshah, A, Kiuchi, T, Galanty, Y, Pangon, L, Densham, R, Ng, T, Butler, L, Boutell, C, Weekes, D

Nature 2009
19287951 A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells

Xu, J, Reddy, ES, Watkins, T, Rao, VN, Reddy, A

Int. J. Oncol. 2009
Catalyst Activity

SUMO transferase activity of PIAS1,4 [nucleoplasm]

Orthologous Events
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