PIAS4 SUMOylates TP53BP1 with SUMO1

Stable Identifier
R-HSA-2997723
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO1 to TP53BP1
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PIAS4 SUMOylates TP53BP1 with SUMO1 in response to double-strand breaks in DNA (Galanty et al. 2009, Impens et al. 2014). Overall, like TP53BP1, SUMO1,2,3, UBE2I, PIAS1 and PIAS4 are all observed to accumulate at double-strand breaks.

Literature References
PubMed ID Title Journal Year
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
20016603 Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

Galanty, Y, Belotserkovskaya, R, Coates, J, Polo, S, Miller, KM, Jackson, SP

Nature 2009
Participants
Participates
Event Information
Go Biological Process
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Orthologous Events
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