PIAS4 SUMOylates TP53BP1 with SUMO1 in response to double-strand breaks in DNA (Galanty et al. 2009, Impens et al. 2014). Overall, like TP53BP1, SUMO1,2,3, UBE2I, PIAS1 and PIAS4 are all observed to accumulate at double-strand breaks.
Impens, F, Radoshevich, L, Cossart, P, Ribet, D
Galanty, Y, Belotserkovskaya, R, Coates, J, Polo, S, Miller, KM, Jackson, SP
SUMO transferase activity of PIAS4 [nucleoplasm]
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