Reactome | PIAS4 SUMOylates TP53BP1 with SUMO1

PIAS4 SUMOylates TP53BP1 with SUMO1

Stable Identifier

R-HSA-2997723

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Conjugation of SUMO1 to TP53BP1

Locations in the PathwayBrowser

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Summation

PIAS4 SUMOylates TP53BP1 with SUMO1 in response to double-strand breaks in DNA (Galanty et al. 2009, Impens et al. 2014). Overall, like TP53BP1, SUMO1,2,3, UBE2I, PIAS1 and PIAS4 are all observed to accumulate at double-strand breaks.

Literature References

PubMed ID	Title	Journal	Year
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli	Proc. Natl. Acad. Sci. U.S.A.	2014
20016603	Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks	Nature	2009

Participants

Input

Output

Participant Of

hasEvent

SUMOylation of transcription factors

Event Information

Go Biological Process

protein sumoylation (0016925)

Catalyst Activity

Catalyst Activity

Title

SUMO transferase activity of PIAS4 [nucleoplasm]

Physical Entity

PIAS4 [nucleoplasm]

Activity

SUMO transferase activity (0019789)

Orthologous Events

PIAS4 SUMOylates TP53BP1 with SUMO1 (Bos taurus)

PIAS4 SUMOylates TP53BP1 with SUMO1 (Caenorhabditis elegans)

PIAS4 SUMOylates TP53BP1 with SUMO1 (Canis familiaris)

PIAS4 SUMOylates TP53BP1 with SUMO1 (Danio rerio)

PIAS4 SUMOylates TP53BP1 with SUMO1 (Dictyostelium discoideum)

PIAS4 SUMOylates TP53BP1 with SUMO1 (Gallus gallus)

PIAS4 SUMOylates TP53BP1 with SUMO1 (Mus musculus)

PIAS4 SUMOylates TP53BP1 with SUMO1 (Rattus norvegicus)

PIAS4 SUMOylates TP53BP1 with SUMO1 (Sus scrofa)

PIAS4 SUMOylates TP53BP1 with SUMO1 (Taeniopygia guttata)

PIAS4 SUMOylates TP53BP1 with SUMO1 (Xenopus tropicalis)

Authored

May, B, 2013-01-19

Reviewed

Galanty, Yaron, 2015-10-10

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