PIAS4 SUMOylates TP53BP1 with SUMO1

Stable Identifier
R-HSA-2997723
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Conjugation of SUMO1 to TP53BP1
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PIAS4 SUMOylates TP53BP1 with SUMO1
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PIAS4 SUMOylates TP53BP1 with SUMO1 in response to double-strand breaks in DNA (Galanty et al. 2009, Impens et al. 2014). Overall, like TP53BP1, SUMO1,2,3, UBE2I, PIAS1 and PIAS4 are all observed to accumulate at double-strand breaks.

Literature References
PubMed ID Title Journal Year
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli

Impens, F, Radoshevich, L, Cossart, P, Ribet, D

Proc. Natl. Acad. Sci. U.S.A. 2014
20016603 Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

Galanty, Y, Belotserkovskaya, R, Coates, J, Polo, S, Miller, KM, Jackson, SP

Nature 2009
Participants
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Output
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as an event of
Event Information
Go Biological Process
protein sumoylation (0016925)
Catalyst Activity

SUMO transferase activity of PIAS4 [nucleoplasm]

Physical Entity
PIAS4 [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
PIAS4 SUMOylates TP53BP1 with SUMO1 (Caenorhabditis elegans)
PIAS4 SUMOylates TP53BP1 with SUMO1 (Danio rerio)
PIAS4 SUMOylates TP53BP1 with SUMO1 (Dictyostelium discoideum)
PIAS4 SUMOylates TP53BP1 with SUMO1 (Gallus gallus)
PIAS4 SUMOylates TP53BP1 with SUMO1 (Mus musculus)
PIAS4 SUMOylates TP53BP1 with SUMO1 (Rattus norvegicus)
PIAS4 SUMOylates TP53BP1 with SUMO1 (Saccharomyces cerevisiae)
PIAS4 SUMOylates TP53BP1 with SUMO1 (Schizosaccharomyces pombe)
Authored
May, B  (2013-01-19)
Reviewed
Galanty, Y  (2015-10-10)
Created
May, B  (2013-01-24)
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