PIAS4 SUMOylates TP53BP1 with SUMO1

Stable Identifier
R-HSA-2997723
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO1 to TP53BP1
Locations in the PathwayBrowser
Summation

PIAS4 SUMOylates TP53BP1 with SUMO1 in response to double-strand breaks in DNA (Galanty et al. 2009, Impens et al. 2014). Overall, like TP53BP1, SUMO1,2,3, UBE2I, PIAS1 and PIAS4 are all observed to accumulate at double-strand breaks.

Literature References
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed