Reactome | PIAS4 SUMOylates TP53BP1 with SUMO1

PIAS4 SUMOylates TP53BP1 with SUMO1

Stable Identifier

R-HSA-2997723

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Conjugation of SUMO1 to TP53BP1

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PIAS4 SUMOylates TP53BP1 with SUMO1 in response to double-strand breaks in DNA (Galanty et al. 2009, Impens et al. 2014). Overall, like TP53BP1, SUMO1,2,3, UBE2I, PIAS1 and PIAS4 are all observed to accumulate at double-strand breaks.

Literature References

PubMed ID	Title	Journal	Year
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Radoshevich, L, Cossart, P, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014
20016603	Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks Galanty, Y, Belotserkovskaya, R, Coates, J, Polo, S, Miller, KM, Jackson, SP	Nature	2009