Reactome | ECM proteoglycans

ECM proteoglycans

Stable Identifier

R-HSA-3000178

DOI

10.3180/REACT_163906.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Proteoglycans are major components of the extracellular matrix. In cartilage the matrix constitutes more than 90% of tissue dry weight. Proteoglycans are proteins substituted with glycosaminoglycans (GAGs), linear polysaccharides consisting of a repeating disaccharide, generally of an acetylated amino sugar alternating
with a uronic acid. Most proteoglycans are located in the extracellular
space. Proteoglycans are highly diverse, both in terms of the core proteins and the subtypes of GAG chains, namely chondroitin sulfate (CS), keratan sulfate (KS), dermatan sulfate (DS) and heparan sulfate (HS). Hyaluronan is a non-sulfated GAG whose molecular weight runs into millions of Dalton; in articular cartilage, a single hyaluronan molecule can hold upto 100 aggrecan molecules and these aggregates are stabilized by a link protein.

Literature References

PubMed ID	Title	Journal	Year
	Cell Biology of Extracellular Matrix Hay, E		1991
21307119	Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor Kim, SH, Turnbull, J, Guimond, S	J. Endocrinol.	2011
	Proteoglycans and Sulfated Glycosaminoglycans Esko, JD, Esko, JD, Kimata, K, Lindahl, U, Varki, A, Cummings, RD, Freeze, HH, Stanley, P, Bertozzi, CR, Hart, GW, Etzler, ME		2009
	Cell Biology of Extracellular Matrix Hay, E		1991