BORA binds PLK1 and AURKA

Stable Identifier
R-HSA-3000319
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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BORA is able to interact with both AURKA (Aurora A kinase) and PLK1. Binding of BORA to PLK1 increases the accessibility of PLK1 threonine residue T210 and also brings PLK1 in proximity to AURKA, enabling AURKA to phosphorylate T210 of PLK1 and thereby activate PLK1 (Seki et al. 2008). While BORA is required for mitotic activation of AURKA in Drosophila (Hutterer et al. 2006), it does not significantly activate AURKA in human cells (Seki et al. 2008). AURKA is able to phosphorylate BORA in vitro, but the functional significance of this modification has not been determined (Hutterer et al. 2006).

Literature References
PubMed ID Title Journal Year
16890155 Mitotic activation of the kinase Aurora-A requires its binding partner Bora

Hutterer, A, Berdnik, D, Wirtz-Peitz, F, Zigman, M, Schleiffer, A, Knoblich, JA

Dev. Cell 2006
18566290 Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

Seki, A, Coppinger, JA, Jang, CY, Yates, JR, Fang, G

Science 2008
Participants
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