RANBP2 SUMOylates SP100 with SUMO2

Stable Identifier
R-HSA-3000348
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO2 to SP100
Locations in the PathwayBrowser
Summation

RANBP2 of the nuclear pore complex SUMOylates SP100 with SUMO2 at lysine-297 (Tatham et al. 2005, Hendriks et al. 2014). RANBP2 binds UBE2I (UBC9) to facilitate the transfer of SUMO2 from SUMO2:UBE2I to SP100 (Tatham et al. 2005).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
Physical Entity
Activity
Orthologous Events