RANBP2 SUMOylates SP100 with SUMO2

Stable Identifier
R-HSA-3000348
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO2 to SP100
Locations in the PathwayBrowser
Summation

RANBP2 of the nuclear pore complex SUMOylates SP100 with SUMO2 at lysine-297 (Tatham et al. 2005, Hendriks et al. 2014). RANBP2 binds UBE2I (UBC9) to facilitate the transfer of SUMO2 from SUMO2:UBE2I to SP100 (Tatham et al. 2005).

Literature References
PubMed ID Title Journal Year
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner

Hendriks, IA, D'Souza, RC, Yang, B, Verlaan-de Vries, M, Mann, M, Vertegaal, AC

Nat. Struct. Mol. Biol. 2014
15608651 Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection

Tatham, MH, Kim, S, Jaffray, E, Song, J, Chen, Y, Hay, RT

Nat. Struct. Mol. Biol. 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed