Reactome | monoSUMO1-K297-SP100 [nucleoplasm]

monoSUMO1-K297-SP100 [nucleoplasm]

Stable Identifier

R-HSA-3000382

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO1 N-glycyl-lys297 SP100, Nuclear autoantigen Sp-100, SP100_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9UKL3 CASP8AP2

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Literature References

PubMed ID	Title	Journal	Year
10212234	The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers Reich, B, Sternsdorf, T, Will, H, Jensen, K	J. Biol. Chem.	1999

External Reference Information

External Reference

UniProt:P23497 SP100

Gene Names

SP100

Chain

initiator methionine:, chain:2-879

Reference Genes

COSMIC (genes):SP100 SP100

dbSNP Gene:6672 SP100

ENSEMBL:ENSG00000067066 SP100

Participates

as an output of

RANBP2 SUMOylates SP100 with SUMO1 (Homo sapiens)

Other forms of this molecule

polySUMO2-K297-SP100 [nucleoplasm]

SP100 [nucleoplasm]

Inferred To

Sp100 [nucleoplasm] (Mus musculus)

Sp100 [nucleoplasm] (Rattus norvegicus)

aire [nucleoplasm] (Xenopus tropicalis)

LOC100517129 [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (monoSUMO1 [nucleoplasm]) at 297

Coordinate

297

Modification

monoSUMO1 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.764	6
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.666	6
UniProt:Q9Y228 T3JAM			0.666	4
UniProt:Q8TF65 GIPC2			0.666	4
UniProt:P03169 VIE1			0.625	4
UniProt:Q9UKL3 CASP8AP2	2	monoSUMO1-K1813-CASP8AP2 [nucleoplasm] (R-HSA-3927850) CASP8AP2 [nucleoplasm] (R-HSA-3927945)	0.602	5
UniProt:Q59GP6 Q59GP6			0.556	3
UniProt:Q96GY0 ZC21A			0.556	3
UniProt:P0DTD1-PRO_0000449627 REP			0.556	3
UniProt:V9HWG0 V9HWG0			0.556	3
UniProt:Q96JM7 LMBL3			0.556	3
UniProt:Q9Y2J4-4 AMOTL2			0.556	3
UniProt:Q14D33 RTP5			0.556	3
UniProt:Q14498-3 RBM39			0.556	3
UniProt:Q92630 DYRK2	3	DYRK2 [nucleoplasm] (R-HSA-3215037) p-T106,S442-DYRK2 [nucleoplasm] (R-HSA-6798368) PolyUb-DYRK2 [nucleoplasm] (R-HSA-6798383)	0.556	3
UniProt:Q9Y6K1 DNMT3A	2	DNMT3A [nucleoplasm] (R-HSA-212287) monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415)	0.556	3
UniProt:P23497 SP100	3	polySUMO2-K297-SP100 [nucleoplasm] (R-HSA-3000454) monoSUMO1-K297-SP100 [nucleoplasm] (R-HSA-3000382) SP100 [nucleoplasm] (R-HSA-1031705)	0.553	2
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.547	2
UniProt:P09429 HMGB1	5	HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [nucleoplasm] (R-HSA-266221) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [secretory granule lumen] (R-HSA-6803337) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291)	0.527	2
UniProt:P55854 SUMO3	5	UBE2I-G92-SUMO3 [nucleoplasm] (R-HSA-3730611) SUMO3 [nucleoplasm] (R-HSA-2984269) lysyl-G92-SUMOyl-K11-SUMO3 [nucleoplasm] (R-HSA-9761547) UBA2-G92-SUMO3 [nucleoplasm] (R-HSA-3730627) SUMO3(1-103) [nucleoplasm] (R-HSA-2990830)	0.524	2
UniProt:P14921 ETS1	2	ETS1 [nucleoplasm] (R-HSA-1629809) p-T38-ETS1 [nucleoplasm] (R-HSA-3132720)	0.508	4
UniProt:Q85601 REX			0.488	2
UniProt:Q03060 CREM			0.488	2
UniProt:P0C206 REX			0.488	2
UniProt:P03410 TAX			0.488	2
UniProt:Q8AZK7 EBNA5			0.482	2

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