Reactome | UBE2I, HDAC7 SUMOylate PML with SUMO1

UBE2I, HDAC7 SUMOylate PML with SUMO1

Stable Identifier

R-HSA-3000383

Type

Reaction

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Conjugation of SUMO1 to PML

Locations in the PathwayBrowser

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Summation

UBE2I (UBC9) alone and in association with HDAC7 can SUMOylate PML with SUMO1 at lysine-65, lysine-160, and lysine-490 (Sternsdorf et al. 1997, Kamitani et al. 1998, Duprez et al. 1999, Knipscheer et al. 2008). SUMOylated PML is observed during interphase but not during mitosis (Everett et al. 1999). Knockdown of HDAC7 reduces the number of PML bodies (Gao et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
9756909	Identification of three major sentrinization sites in PML	J. Biol. Chem.	1998
18691969	Ubc9 sumoylation regulates SUMO target discrimination	Mol. Cell	2008
21098080	A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells	Mol. Cell Proteomics	2011
9452416	Covalent modification of PML by the sentrin family of ubiquitin-like proteins	J. Biol. Chem.	1998
9412458	Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1	J. Cell Biol.	1997
9885291	SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation	J. Cell. Sci.	1999
18625722	Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation	Mol. Cell. Biol.	2008
10574707	Cell cycle regulation of PML modification and ND10 composition	J. Cell. Sci.	1999