Reactome: A Curated Pathway Database

UBE2I, HDAC7 SUMOylate PML with SUMO1

Stable Identifier
R-HSA-3000383
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO1 to PML
Locations in the PathwayBrowser
Summation

UBE2I (UBC9) alone and in association with HDAC7 can SUMOylate PML with SUMO1 at lysine-65, lysine-160, and lysine-490 (Sternsdorf et al. 1997, Kamitani et al. 1998, Duprez et al. 1999, Knipscheer et al. 2008). SUMOylated PML is observed during interphase but not during mitosis (Everett et al. 1999). Knockdown of HDAC7 reduces the number of PML bodies (Gao et al. 2008).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of UBE2I,HDAC7 [nucleoplasm] UBE2I,HDAC7 [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events