Reactome: A Curated Pathway Database

UBE2I, HDAC7 SUMOylate PML with SUMO1

Stable Identifier
R-HSA-3000383
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Conjugation of SUMO1 to PML
Locations in the PathwayBrowser
Summation

UBE2I (UBC9) alone and in association with HDAC7 can SUMOylate PML with SUMO1 at lysine-65, lysine-160, and lysine-490 (Sternsdorf et al. 1997, Kamitani et al. 1998, Duprez et al. 1999, Knipscheer et al. 2008). SUMOylated PML is observed during interphase but not during mitosis (Everett et al. 1999). Knockdown of HDAC7 reduces the number of PML bodies (Gao et al. 2008).

Literature References
PubMed ID Title Journal Year
9756909 Identification of three major sentrinization sites in PML J. Biol. Chem. 1998
18691969 Ubc9 sumoylation regulates SUMO target discrimination Mol. Cell 2008
21098080 A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells Mol. Cell Proteomics 2011
9452416 Covalent modification of PML by the sentrin family of ubiquitin-like proteins J. Biol. Chem. 1998
9412458 Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1 J. Cell Biol. 1997
9885291 SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation J. Cell. Sci. 1999
18625722 Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation Mol. Cell. Biol. 2008
10574707 Cell cycle regulation of PML modification and ND10 composition J. Cell. Sci. 1999
Participants
input
output
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of UBE2I,HDAC7 [nucleoplasm] UBE2I,HDAC7 [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events
 
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