Reactome | polySUMO3-K65,K160,K490-PML [nucleoplasm]

polySUMO3-K65,K160,K490-PML [nucleoplasm]

Stable Identifier

R-HSA-3000386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO3 N-glycyl-lys65,160,490 PML, Protein PML, PML_HUMAN

Locations in the PathwayBrowser

Expand all

General

Fu et al. (2005) report that only lysine-160 is conjugated to SUMO3. Gong and Yeh (2006) report that lysine-65, lysine-160, and lysine-490 are conjugated to SUMO3.

Literature References

PubMed ID	Title	Journal	Year
16608850	Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3 Yeh, ET, Gong, L	J. Biol. Chem.	2006
15940266	Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3 Yang, Z, Fu, C, Zhu, Y, Ding, X, Ding, H, Lan, J, Huang, H, Shi, Y, Ahmed, K, Miao, Y, Yao, X, Zhu, J	Oncogene	2005

External Reference Information

External Reference

UniProt:P29590 PML

Gene Names

PML, MYL, PP8675, RNF71, TRIM19

Chain

chain:1-882

Reference Genes

BioGPS Gene:5371 PML

COSMIC (genes):PML PML

CTD Gene:5371 PML

dbSNP Gene:5371 PML

ENSEMBL:ENSG00000140464 PML

ENSEMBL:ENSG00000140464.20 PML

HGNC:9113 PML

KEGG Gene (Homo sapiens):5371 PML

Monarch:5371 PML

NCBI Gene:5371 PML

OMIM:102578 PML

UCSC:P29590 PML

Reference Transcript

Other Identifiers

11726875_a_at

11726876_a_at

11728557_s_at

11729443_a_at

11741878_a_at

11741879_x_at

11745905_a_at

11751121_a_at

11751251_a_at

16802918

16802939

206503_PM_x_at

206503_x_at

210362_PM_x_at

210362_x_at

211012_PM_s_at

211012_s_at

211013_PM_x_at

211013_x_at

211014_PM_s_at

211014_s_at

211588_PM_s_at

211588_s_at

239582_PM_at

239582_at

3601388

3601389

3601390

3601393

3601394

3601395

3601401

3601403

3601410

3601412

3601413

3601414

3601415

3601416

3601417

3601418

3601419

3601420

3601421

3601422

3601423

3601424

3601425

3601426

3601427

3601428

3601436

3601437

3601438

3601439

3601441

3601442

3601443

3601445

3601447

3601449

3601450

3601451

38787_at

38788_at

5371

566_at

567_s_at

7984779

A_14_P130961

A_21_P0008833

A_23_P306148

A_23_P334664

A_23_P358944

A_24_P133542

A_24_P198598

A_24_P207139

GE515151

GE58085

GO:0000278

GO:0000781

GO:0000792

GO:0001666

GO:0002230

GO:0002376

GO:0003677

GO:0003713

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005768

GO:0005783

GO:0005789

GO:0005829

GO:0006281

GO:0006351

GO:0006355

GO:0006605

GO:0006606

GO:0006886

GO:0006913

GO:0006915

GO:0006919

GO:0006977

GO:0007155

GO:0007179

GO:0007182

GO:0008270

GO:0008285

GO:0008630

GO:0008631

GO:0009411

GO:0010332

GO:0010522

GO:0010761

GO:0012501

GO:0016020

GO:0016363

GO:0016525

GO:0016605

GO:0016740

GO:0016925

GO:0019789

GO:0023052

GO:0030099

GO:0030154

GO:0030155

GO:0030163

GO:0030308

GO:0030578

GO:0031065

GO:0031410

GO:0031503

GO:0031625

GO:0031901

GO:0032183

GO:0032200

GO:0032206

GO:0032211

GO:0032469

GO:0032691

GO:0032692

GO:0032922

GO:0032938

GO:0034097

GO:0036211

GO:0042752

GO:0042771

GO:0042802

GO:0042803

GO:0043153

GO:0043161

GO:0043226

GO:0044790

GO:0045087

GO:0045165

GO:0045892

GO:0045893

GO:0046332

GO:0046872

GO:0048146

GO:0048384

GO:0048511

GO:0048856

GO:0048870

GO:0050821

GO:0050897

GO:0051457

GO:0051607

GO:0051726

GO:0051974

GO:0055065

GO:0055085

GO:0060058

GO:0060444

GO:0061659

GO:0065003

GO:0070059

GO:0071353

GO:0072332

GO:0090398

GO:0090402

GO:0097191

GO:0098542

GO:0140037

GO:0140096

GO:0140110

GO:1901798

GO:1904816

GO:1990830

GO:2000059

GO:2000758

GO:2000779

GO:2001235

GO:2001238

HMNXSV003003061

HMNXSV003024547

HMNXSV003051703

HMNXSV003054775

Hs.258217.0.A1_3p_at

ILMN_1731299

ILMN_1750861

ILMN_1811588

ILMN_2248192

ILMN_2398378

M79462_at

M79463_s_at

PH_hs_0005007

TC15000671.hg

TC15002275.hg

TC15002276.hg

X63131_s_at

g12275906_3p_s_at

g12275908_3p_s_at

g190116_3p_at

g4505902_3p_a_at

p19791

Participates

as an output of

SUMOylation of PML with SUMO3 (Homo sapiens)

Other forms of this molecule

polySUMO2-K65,K160,K490-PML [nucleoplasm]

monoSUMO1-K65,160,490-PML [nucleoplasm]

PML [nucleoplasm]

PML [cytosol]

Inferred To

Pml [nucleoplasm] (Rattus norvegicus)

polySUMO3-K65,K160,K490-PML [nucleoplasm] (Canis familiaris)

polySUMO3-K65,K160,K490-PML [nucleoplasm] (Dictyostelium discoideum)

polySUMO3-K65,K160,K490-PML [nucleoplasm] (Mus musculus)

PML [nucleoplasm] (Bos taurus)

Modified Residues

Name

sumoylated lysine (polySUMO3 [nucleoplasm]) at 65

Coordinate

Modification

polySUMO3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (polySUMO3 [nucleoplasm]) at 160

Coordinate

160

Modification

polySUMO3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (polySUMO3 [nucleoplasm]) at 490

Coordinate

490

Modification

polySUMO3 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_150252.1, NP_150243.2, NP_150253.2, NP_150242.1, NP_150249.1, NP_002666.1, NP_150250.2, NP_150247.2, NP_150241.2

OpenTargets

ENSG00000140464

HPA

ENSG00000140464-PML

GeneCards

P29590

Ensembl

ENST00000569477, ENSP00000455612, ENST00000354026, ENST00000565898, ENSP00000457023, ENSP00000315434, ENST00000564428, ENST00000395135, ENST00000395132, ENSP00000268058, ENSP00000455838, ENSG00000140464, ENSP00000394642, ENSP00000378567, ENSP00000378564, ENST00000435786, ENST00000567543, ENSP00000353004, ENSP00000395576, ENSP00000456277, ENST00000359928, ENST00000436891, ENSP00000268059, ENSP00000456486, ENST00000268058, ENST00000268059, ENST00000569965

PRO

P29590

Pharos - Targets

P29590

Orphanet

15112

PDB

6UYT, 6UYQ, 1BOR, 4WJO, 6IMQ, 2MVW, 8DJI, 6UYV, 6UYS, 5YUF, 8DJH, 6UYP, 6UYU, 6UYO, 6UYR, 2MWX, 4WJN

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.832	6
UniProt:Q9UER7 DAXX	13	monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX S138* [nucleoplasm] (R-HSA-9673081) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A36Qfs*108 [nucleoplasm] (R-HSA-9673105) DAXX [nucleoplasm] (R-HSA-3222068)	0.791	6
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.744	9
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.7	4
UniProt:P03243-1			0.621	3
UniProt:Q05516 ZBTB16	1	ZBTB16 [cytosol] (R-HSA-976047)	0.611	7
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.609	6
UniProt:Q13164 MAPK7	4	MAPK7 [nucleoplasm] (R-HSA-199961) MAPK7 [cytosol] (R-HSA-198754) p-T218,Y221-MAPK7 [cytosol] (R-HSA-198721) p-T218,Y221-MAPK7 [nucleoplasm] (R-HSA-198738)	0.571	6
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.556	3
UniProt:Q8UN00 Q8UN00			0.556	4
UniProt:P29590 PML	5	polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) PML [nucleoplasm] (R-HSA-1031706) PML [cytosol] (R-HSA-5624327)	0.553	2
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.524	4
UniProt:P25788 PSMA3	2	PSMA3 [nucleoplasm] (R-HSA-174323) PSMA3 [cytosol] (R-HSA-68728)	0.508	2
UniProt:P03255-1			0.463	2
UniProt:O15055 PER2	4	Ub-p-S-PER2 [cytosol] (R-HSA-517835) PER2 [cytosol] (R-HSA-400399) p-S-PER2 [nucleoplasm] (R-HSA-3325591) p-S-PER2 [cytosol] (R-HSA-400331)	0.463	3
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.463	3
UniProt:O15169 AXIN1	11	AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841)	0.463	2
UniProt:P27958-PRO_0000037566			0.463	6
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.463	2

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