Reactome: A Curated Pathway Database

RANBP2 SUMOylates SP100 with SUMO1

Stable Identifier
R-HSA-3000399
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO1 to SP100
Locations in the PathwayBrowser
Summation

RANBP2 SUMOylates SP100 with SUMO1 at lysine-297 (Pichler et al. 2002, Tatham et al. 2005). RANBP2 has a binding site for SUMO1 and a binding site for UBE2I (UBC9) which may recruit the SUMO1:UBE2I (SUMO1:UBC9) complex (Tatham et al. 2005). RANBP2 is located on the cytoplasmic filaments of the nuclear pore so that SUMOylation may occur during nuclear import of SP100 (Pichler et al. 2002)

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope] Nuclear Pore Complex (NPC) [nuclear envelope] SUMO transferase activity (0019789)
Orthologous Events