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RANBP2 SUMOylates PML with SUMO2

Stable Identifier
R-HSA-3000411
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO2 to PML
Locations in the PathwayBrowser
Summation

RANBP2 of the nuclear pore complex SUMOylates PML with SUMO2 at lysine-65, lysine-160, and lysine-490 (Kamitani et al. 1998, Tatham et al. 2005). RANBP2 contains both a binding site for SUMO1 and a binding site for UBE2I (Tatham et al. 2005). The binding site for UBE2I participates in SUMOylation of PML with SUMO2. SUMO2 colocalizes significantly with PML bodies (Vertegaal et al. 2004).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of Nuclear Pore Complex (NPC) [nuclear envelope]
Physical Entity
Activity
Orthologous Events