Reactome | SUMO1-K524-RANGAP1 [nuclear envelope]

SUMO1-K524-RANGAP1 [nuclear envelope]

Stable Identifier

R-HSA-3000416

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

SUMO1 N-glycyl-lys524 RANGAP1, Ran GTPase-activating protein 1, RAGP1_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
19721078	"ChopNSpice," a mass spectrometric approach that allows identification of endogenous small ubiquitin-like modifier-conjugated peptides Hsiao, HH, Meulmeester, E, Melchior, F, Urlaub, H, Frank, BT	Mol. Cell Proteomics	2009
11853669	Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1 Sampson, DA, Bernier-Villamor, V, Matunis, MJ, Lima, CD	Cell	2002

External Reference Information

External Reference

UniProt:P46060 RANGAP1

Gene Names

RANGAP1, KIAA1835, SD

Chain

initiator methionine:1, chain:2-587

Reference Genes

BioGPS Gene:5905 RANGAP1

COSMIC (genes):RANGAP1 RANGAP1

CTD Gene:5905 RANGAP1

dbSNP Gene:5905 RANGAP1

ENSEMBL:ENSG00000100401 RANGAP1

HGNC:9854 RANGAP1

KEGG Gene (Homo sapiens):5905 RANGAP1

Monarch:5905 RANGAP1

NCBI Gene:5905 RANGAP1

OMIM:602362 RANGAP1

UCSC:P46060 RANGAP1

Reference Transcript

Other Identifiers

0005340739

11717164_a_at

11717165_a_at

1553535_a_at

16935396

212125_at

212127_at

32151_at

3961843

3961844

3961845

3961846

3961847

3961848

3961851

3961852

3961855

3961857

3961858

3961859

3961860

3961862

3961864

3961865

3961869

3961872

3961873

3961874

3961876

3961877

3961878

3961879

3961880

3961881

3961883

3961885

3961886

3961887

3961888

3961889

5905

8076307

A_23_P333420

A_33_P3263307

GE62508

GO:0000278

GO:0000775

GO:0000776

GO:0000777

GO:0003674

GO:0003723

GO:0005096

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005694

GO:0005737

GO:0005819

GO:0005829

GO:0005856

GO:0006464

GO:0006810

GO:0006913

GO:0006950

GO:0007010

GO:0007049

GO:0007052

GO:0007084

GO:0007165

GO:0008150

GO:0015031

GO:0016235

GO:0016925

GO:0019899

GO:0030234

GO:0030425

GO:0031267

GO:0031625

GO:0031965

GO:0032991

GO:0043226

GO:0043231

GO:0043547

GO:0044614

GO:0045296

GO:0046826

GO:0048471

GO:0048678

GO:0061024

GO:0071375

GO:0072686

GO:0090630

GO:0140014

GO:1904115

GO:1904117

GO:1990723

HMNXSV003050468

Hs.183800.0.S1_3p_at

Hs.183800.0.S2_3p_at

Hs2.183800.1.S1_3p_s_at

ILMN_1662198

PH_hs_0029369

TC22000823.hg

Participates

as a component of

SUMO1:RANGAP1 [nuclear envelope] (Homo sapiens)

Other forms of this molecule

RANGAP1 [nuclear envelope]

RANGAP1 [cytosol]

Inferred To

RanGAP [nuclear envelope] (Drosophila melanogaster)

rna1 [nuclear envelope] (Schizosaccharomyces pombe)

Rangap1 [nuclear envelope] (Mus musculus)

Rangap1 [nuclear envelope] (Rattus norvegicus)

ran-2 [nuclear envelope] (Caenorhabditis elegans)

rangap1 [nuclear envelope] (Xenopus tropicalis)

RANGAP1 [nuclear envelope] (Sus scrofa)

SUMO1-K524-RANGAP1 [nuclear envelope] (Dictyostelium discoideum)

SUMO1-K524-RANGAP1 [nuclear envelope] (Gallus gallus)

rangap1a [nuclear envelope] (Danio rerio)

RNA1 [nuclear envelope] (Saccharomyces cerevisiae)

Modified Residues

Name

Inter-chain Crosslink via sumoylated lysine at 524 and 97

Coordinate

524

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

XP_011528597.1, NP_002874.1, XP_016884383.1, XP_016884385.1, XP_011528596.1, NP_001304859.1, XP_006724352.1, XP_016884382.1, XP_016884384.1, XP_016884386.1, NP_001265580.1

OpenTargets

ENSG00000100401

GeneCards

P46060

HPA

ENSG00000100401-RANGAP1

Ensembl

ENST00000405486, ENST00000356244, ENSP00000385866, ENSP00000348577, ENST00000455915, ENSG00000100401, ENSP00000401470

PRO

P46060

Pharos - Targets

P46060

GlyGen

P46060

Orphanet

24848

PDB

5D2M, 2GRQ, 2GRP, 3UIP, 3UIN, 2GRO, 2GRR, 2IY0, 2GRN, 2IO3, 2IO2, 1Z5S, 3UIO

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	20	K676-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090396) ING2-G97-SUMO1 [nucleoplasm] (R-HSA-4086096) K554-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782555) K2592-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551627) K804-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782561) K2723-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551737) K750-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090298) TOPORS-G97-SUMO1 [nucleoplasm] (R-HSA-4551623) K2650-RANBP2-G97-SUMO1 [nuclear envelope] (R-HSA-4551591) K788-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085297) K731-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085312) K779-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-3782585) K171-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551632) K239-Ncoa2-G97-SUMO1 [nucleoplasm] (R-HSA-4085320) PIAS4-G97-SUMO1 [nucleoplasm] (R-HSA-3968375) K196-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551630) K14-UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-4085334) K159-VHL-G97-SUMO1 [nucleoplasm] (R-HSA-4551713) MDM-G97-SUMO1 [nucleoplasm] (R-HSA-3730829) K575-TRIM28-G97-SUMO1 [nucleoplasm] (R-HSA-4090305)	0.962	14
UniProt:P63279 UBE2I	8	SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [nuclear envelope] (R-HSA-4655408) UBE2I [cytosol] (R-HSA-4655342) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481)	0.946	13
UniProt:P61956 SUMO2	5	SUMO2(1-95) [nucleoplasm] (R-HSA-2990837) MDC1-SUMO2 [nucleoplasm] (R-HSA-5684062) SUMO2 [nucleoplasm] (R-HSA-2984281) UBE2I-G93-SUMO2 [nucleoplasm] (R-HSA-3730625) UBA2-G93-SUMO2 [nucleoplasm] (R-HSA-3730618)	0.75	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:P49792 RANBP2	6	RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2 [nuclear envelope] (R-HSA-2993756) RANBP2(1-867)-p-7Y ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2 [cytosol] (R-HSA-157703) SUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720) SUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599)	0.623	4
UniProt:Q9P0U3 SENP1	2	SENP1 [cytosol] (R-HSA-9715128) SENP1 [nucleoplasm] (R-HSA-2984299)	0.591	4
UniProt:Q9HC62 SENP2	1	SENP2 [nucleoplasm] (R-HSA-2984298)	0.591	6
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.527	2
UniProt:P05412 JUN	4	p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.462	2

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