Reactome | polySUMO2-K65,K160,K490-PML [nucleoplasm]

polySUMO2-K65,K160,K490-PML [nucleoplasm]

Stable Identifier

R-HSA-3000423

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SUMO2 N-glycyl-lys65,160,490 PML, Protein PML, PML_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
24782567	Proteome-wide identification of SUMO2 modification sites Tammsalu, T, Matic, I, Jaffray, EG, Ibrahim, AF, Tatham, MH, Hay, RT	Sci Signal	2014
16608850	Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3 Gong, L, Yeh, ET	J. Biol. Chem.	2006
9452416	Covalent modification of PML by the sentrin family of ubiquitin-like proteins Kamitani, T, Nguyen, HP, Kito, K, Fukuda-Kamitani, T, Yeh, ET	J. Biol. Chem.	1998

External Reference Information

External Reference

UniProt:P29590 PML

Gene Names

PML, MYL, PP8675, RNF71, TRIM19

Chain

chain:1-882

Reference Genes

BioGPS Gene:5371 PML

COSMIC (genes):PML PML

CTD Gene:5371 PML

dbSNP Gene:5371 PML

ENSEMBL:ENSG00000140464 PML

HGNC:9113 PML

KEGG:hsa:5371 PML

Monarch:5371 PML

NCBI Gene:5371 PML

OMIM:102578 PML

UCSC:P29590 PML

Reference Transcript

Participates

as an output of

RANBP2 SUMOylates PML with SUMO2 (Homo sapiens)

Other forms of this molecule

PML [cytosol]

PML [nucleoplasm]

monoSUMO1-K65,160,490-PML [nucleoplasm]

polySUMO3-K65,K160,K490-PML [nucleoplasm]

Inferred To

polySUMO2-K65,K160,K490-PML [nucleoplasm] (Dictyostelium discoideum)

Pml [nucleoplasm] (Mus musculus)

Pml [nucleoplasm] (Rattus norvegicus)

mei-P26 [nucleoplasm] (Drosophila melanogaster)

PML [nucleoplasm] (Bos taurus)

PML [nucleoplasm] (Gallus gallus)

PML [nucleoplasm] (Sus scrofa)

Modified Residues

Name

sumoylated lysine (polySUMO2 [nucleoplasm]) at 65

Coordinate

Modification

polySUMO2 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (polySUMO2 [nucleoplasm]) at 160

Coordinate

160

Modification

polySUMO2 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (polySUMO2 [nucleoplasm]) at 490

Coordinate

490

Modification

polySUMO2 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Cross References

RefSeq

NP_002666.1, NP_150242.1, NP_150247.2, NP_150250.2, NP_150253.2, NP_150249.1, NP_150243.2, NP_150252.1, NP_150241.2

OpenTargets

ENSG00000140464

ENSEMBL

ENST00000354026, ENSP00000394642, ENST00000569477, ENST00000395132, ENST00000565898, ENST00000395135, ENSP00000457023, ENSP00000456277, ENST00000564428, ENSP00000315434, ENST00000436891, ENSP00000395576, ENST00000268059, ENST00000569965, ENST00000268058, ENSP00000455838, ENSP00000268058, ENST00000435786, ENST00000567543, ENSP00000268059, ENSP00000456486, ENSG00000140464, ENSP00000378567, ENSP00000455612, ENSP00000353004, ENSP00000378564, ENST00000359928

GeneCards

PML

HPA

ENSG00000140464-PML

PRO

P29590

Pharos - Targets

P29590

GlyGen

P29590

Orphanet

PML

HMDB Protein

HMDBP14480

PDB

5YUF, 6UYO, 6UYV, 6UYT, 8DJI, 4WJN, 6UYU, 8DJH, 6UYP, 6UYQ, 8J25, 2MVW, 6IMQ, 2MWX, 6UYS, 6UYR, 8J2P, 8YTC, 4WJO, 1BOR

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.832	6
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.813	11
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.791	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.7	4
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.622	5
UniProt:P03243-1			0.621	3
UniProt:Q05516 ZBTB16	1	ZBTB16 [cytosol] (R-HSA-976047)	0.611	7
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.609	6
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.589	3
UniProt:Q13164 MAPK7	4	p-T218,Y221-MAPK7 [nucleoplasm] (R-HSA-198738) p-T218,Y221-MAPK7 [cytosol] (R-HSA-198721) MAPK7 [cytosol] (R-HSA-198754) MAPK7 [nucleoplasm] (R-HSA-199961)	0.571	6
UniProt:Q8UN00 Q8UN00			0.556	4
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.556	3
UniProt:P29590 PML	5	PML [cytosol] (R-HSA-5624327) PML [nucleoplasm] (R-HSA-1031706) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386)	0.553	2
UniProt:O14734 ACOT8	2	ACOT8 [cytosol] (R-HSA-9033134) ACOT8 [peroxisomal matrix] (R-HSA-193426)	0.527	2
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.527	2
UniProt:P02585 TNNC2	1	TNNC2 [cytosol] (R-HSA-390531)	0.527	2
UniProt:Q9HD26 GOPC	3	GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067) GOPC [plasma membrane] (R-HSA-5626572) GOPC [lysosomal membrane] (R-HSA-5627281)	0.527	2
UniProt:O43678 NDUFA2	1	NDUFA2 [mitochondrial inner membrane] (R-HSA-60178)	0.527	2
UniProt:Q9Y5W9 SNX11			0.527	2
UniProt:P28331 NDUFS1	1	NDUFS1 [mitochondrial matrix] (R-HSA-6788513)	0.527	2
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.524	4
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.508	2
UniProt:Q8N9N5 BANP	2	BANP [cytosol] (R-HSA-9934681) BANP [nucleoplasm] (R-HSA-3221973)	0.463	3
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.463	2
UniProt:O15055 PER2	5	PER2 [cytosol] (R-HSA-400399) p-7S-PER2 [nucleoplasm] (R-HSA-9920680) p-7S-PER2 [cytosol] (R-HSA-9920710) p-S396-PER2 [cytosol] (R-HSA-9920705) K48polyUb-K,p-7S-PER2 [cytosol] (R-HSA-9932526)	0.463	3
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) RibC-AXIN1 [cytosol] (R-HSA-3640841) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.463	2
UniProt:P27958-PRO_0000037566			0.463	6
UniProt:P03255-1			0.463	2

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