Reactome: A Curated Pathway Database

SUMOylation of PML with SUMO3

Stable Identifier
R-HSA-3000433
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO3 to PML
Locations in the PathwayBrowser
Summation

PML is observed to be SUMOylated with SUMO3 at lysine-65, lysine-160, and lysine-490 (Kamitani et al. 1998). SUMO3 is almost identical with SUMO2 therefore the same E3 ligase (RANBP2) that SUMOylate PML with SUMO2 may also be active with SUMO3, but this has not been proven. PML colocalizes with SUMO3 in nuclear bodies and disruption of SUMO3 expression reduces the number of nuclear bodies (Fu et al. 2005).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
SUMO transferase activity of SUMO3:UBE2I [nucleoplasm] SUMO3:UBE2I [nucleoplasm] SUMO transferase activity (0019789)
Orthologous Events