PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1

Stable Identifier
R-HSA-3000434
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Conjugation of SUMO1 to MDM2
Locations in the PathwayBrowser
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PML TRIM27, PIAS1, and PIAS2-1 can each SUMOylate MDM2 with SUMO1 at lysine-182 (Miyauchi et al. 2002, Chu and Yang 2011). An unSUMOylatable mutant of MDM2 accumulates in the cytosol so SUMOylation may be part of the process of nuclear import of MDM2 (Miyauchi et al. 2002).

Literature References
PubMed ID Title Journal Year
12393906 Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes

Miyauchi, Y, Yogosawa, S, Honda, R, Nishida, T, Yasuda, H

J. Biol. Chem. 2002
20972456 SUMO E3 ligase activity of TRIM proteins

Chu, Y, Yang, X

Oncogene 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PML,TRIM27,PIAS1,2-1 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created