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polySUMO2-K297-SP100 [nucleoplasm]
Stable Identifier
R-HSA-3000454
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SUMO2 N-glycyl-lys297 SP100, Nuclear autoantigen Sp-100, SP100_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P09429 HMGB1
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
RANBP2 SUMOylates SP100 with SUMO2 (Homo sapiens)
polySUMO2-K297-SP100 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25218447
Uncovering global SUMOylation signaling networks in a site-specific manner
Yang, B
,
Hendriks, IA
,
Verlaan-de Vries, M
,
Vertegaal, AC
,
D'Souza, RC
,
Mann, M
Nat. Struct. Mol. Biol.
2014
External Reference Information
External Reference
UniProt:P23497 SP100
Gene Names
SP100
Chain
initiator methionine:, chain:2-879
Reference Genes
BioGPS Gene:6672 SP100
COSMIC (genes):SP100 SP100
CTD Gene:6672 SP100
dbSNP Gene:6672 SP100
ENSEMBL:ENSG00000067066 SP100
ENSEMBL_homo_sapiens_GENE:ENSG00000067066.17 SP100
HGNC:11206 SP100
KEGG Gene (Homo sapiens):6672 SP100
Monarch:6672 SP100
NCBI Gene:6672 SP100
OMIM:604585 SP100
UCSC:P23497 SP100
Reference Transcript
RefSeq:NM_001080391.1 SP100
RefSeq:NM_003113.3 SP100
RefSeq:NM_001206703.1 SP100
RefSeq:NM_001206701.1 SP100
RefSeq:NM_001206704.1 SP100
RefSeq:NM_001206702.1 SP100
Other Identifiers
11737256_at
11737511_a_at
11744673_a_at
11744783_a_at
11745015_a_at
11747301_a_at
11754917_a_at
11759663_x_at
11759828_s_at
16891922
202863_PM_at
202863_at
202864_PM_s_at
202864_s_at
210218_PM_s_at
210218_s_at
210985_PM_s_at
210985_s_at
2531381
2531382
2531383
2531385
2531389
2531392
2531393
2531394
2531397
2531400
2531402
2531405
2531407
2531410
2531413
2531416
2531420
2531423
2531424
2531425
2531427
2531428
2531430
2531432
2531435
2531441
2531442
2531443
2531446
2531447
2531452
2531456
2531457
2531458
2531459
2531460
2531461
2531474
2531475
2531476
2531477
2531478
2531479
2531480
2531481
2531482
2531483
2531484
2531485
2586472
2613808
3508075
3508077
3631590
3631593
37352_at
37353_g_at
37354_at
3911151
6672
75252_at
8048940
A_14_P138924
A_23_P209712
A_24_P385611
A_33_P3228325
GE79707
GE88625
GO:0000122
GO:0000723
GO:0000781
GO:0000981
GO:0002376
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0006886
GO:0006913
GO:0010596
GO:0012501
GO:0016604
GO:0016605
GO:0019900
GO:0019904
GO:0023052
GO:0030330
GO:0030870
GO:0032200
GO:0032526
GO:0032897
GO:0034097
GO:0034340
GO:0034341
GO:0034399
GO:0042802
GO:0042803
GO:0043226
GO:0043392
GO:0043433
GO:0045185
GO:0045765
GO:0045892
GO:0045944
GO:0046826
GO:0046983
GO:0048384
GO:0048856
GO:0048870
GO:0051091
GO:0060333
GO:0060337
GO:0061629
GO:0070087
GO:0098542
GO:0140110
GO:1902041
GO:1902044
HMNXSV003000701
HMNXSV003017970
HMNXSV003029863
ILMN_1690920
ILMN_2284998
ILMN_2390586
PH_hs_0040866
TC02001377.hg
U36501_at
g1173655_3p_a_at
g3252910_3p_s_at
g4507164_3p_at
Participates
as an output of
RANBP2 SUMOylates SP100 with SUMO2 (Homo sapiens)
Other forms of this molecule
monoSUMO1-K297-SP100 [nucleoplasm]
SP100 [nucleoplasm]
Inferred To
Sp100 [nucleoplasm]
(Mus musculus)
Sp100 [nucleoplasm]
(Rattus norvegicus)
aire [nucleoplasm]
(Xenopus tropicalis)
LOC100517129 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
sumoylated lysine (polySUMO2 [nucleoplasm]) at 297
Coordinate
297
Modification
polySUMO2 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001193631.1
,
NP_001073860.1
,
NP_001193633.1
,
NP_001193632.1
,
NP_003104.2
,
NP_001193630.1
Guide to Pharmacology - Targets
2777
OpenTargets
ENSG00000067066
HPA
ENSG00000067066-SP100
GeneCards
P23497
Ensembl
ENST00000427101
,
ENSP00000399389
,
ENSP00000386404
,
ENSP00000386998
,
ENSP00000264052
,
ENST00000264052
,
ENSG00000067066
,
ENST00000409112
,
ENST00000340126
,
ENST00000409341
,
ENST00000409897
,
ENSP00000386427
,
ENSP00000343023
PRO
P23497
Pharos - Targets
P23497
PDB
5PY2
,
5PX3
,
5PWK
,
5PWT
,
5PWL
,
5PZ6
,
5PX4
,
5PXS
,
5PWV
,
5PZ9
,
5PXL
,
5PYV
,
5PZ8
,
5PXE
,
5PXM
,
5PWW
,
5PXD
,
5PZ2
,
5PZA
,
5PXN
,
5PYP
,
5PYY
,
5PYZ
,
5PZC
,
5PWR
,
5PY0
,
5PX1
,
5PXZ
,
5PWI
,
5PYI
,
5PWJ
,
5PX2
,
5PY8
,
5PYQ
,
5PWS
,
5PYH
,
5PYU
,
5PXR
,
5PYB
,
5PXT
,
5PYT
,
5PX5
,
5PXU
,
5PYX
,
5PZ0
,
5PWM
,
5PYC
,
5PY4
,
5PYW
,
5PX6
,
5PYF
,
5PXF
,
5PYG
,
5PXG
,
5PY6
,
5PZ1
,
5PYO
,
5PY9
,
5PXP
,
5PY1
,
5PY3
,
5PZD
,
5PZ5
,
5PWU
,
5PYJ
,
5PYA
,
6G5P
,
5PYD
,
5PY5
,
5PWN
,
5PXV
,
5PWE
,
5PZF
,
5PWF
,
5PWO
,
5PX7
,
5PWX
,
5PY7
,
5FB0
,
5FB1
,
1H5P
,
5PYN
,
5PYE
,
5PX8
,
5PZH
,
5PXO
,
5PXW
,
5PWY
,
5PXH
,
5PYK
,
5PXJ
,
4PTB
,
5PZ7
,
5PZE
,
5PXC
,
5PXK
,
5PXB
,
5PYM
,
5PZG
,
5PYL
,
6G5N
,
5PWP
,
5PZJ
,
5PWG
,
5PXX
,
5PX0
,
5PZI
,
5PWQ
,
5PWH
,
5PWZ
,
5PYR
,
5PX9
,
5PYS
,
5PXA
,
5PZ3
,
5PZB
,
5PXI
,
5PZ4
,
5PXY
,
5PXQ
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.764
6
UniProt:P35609 ACTN2
3
ACTN2 [cytosol]
(R-HSA-390562)
ACTN2 [platelet alpha granule lumen]
(R-HSA-349727)
ACTN2 [extracellular region]
(R-HSA-349725)
0.666
6
UniProt:Q9Y228 T3JAM
0.666
4
UniProt:Q8TF65 GIPC2
0.666
4
UniProt:P03169 VIE1
0.625
4
UniProt:Q9UKL3 CASP8AP2
2
monoSUMO1-K1813-CASP8AP2 [nucleoplasm]
(R-HSA-3927850)
CASP8AP2 [nucleoplasm]
(R-HSA-3927945)
0.602
5
UniProt:Q59GP6 Q59GP6
0.556
3
UniProt:Q9Y6K1 DNMT3A
2
monoSUMO1-K-DNMT3A [nucleoplasm]
(R-HSA-4655415)
DNMT3A [nucleoplasm]
(R-HSA-212287)
0.556
3
UniProt:Q96GY0 ZC21A
0.556
3
UniProt:P0DTD1-PRO_0000449627 REP
0.556
3
UniProt:V9HWG0 V9HWG0
0.556
3
UniProt:Q96JM7 LMBL3
0.556
3
UniProt:Q9Y2J4-4 AMOTL2
0.556
3
UniProt:Q92630 DYRK2
3
PolyUb-DYRK2 [nucleoplasm]
(R-HSA-6798383)
p-T106,S442-DYRK2 [nucleoplasm]
(R-HSA-6798368)
DYRK2 [nucleoplasm]
(R-HSA-3215037)
0.556
3
UniProt:Q14D33 RTP5
0.556
3
UniProt:Q14498-3 RBM39
0.556
3
UniProt:P23497 SP100
3
polySUMO2-K297-SP100 [nucleoplasm]
(R-HSA-3000454)
monoSUMO1-K297-SP100 [nucleoplasm]
(R-HSA-3000382)
SP100 [nucleoplasm]
(R-HSA-1031705)
0.553
2
UniProt:Q8TAD8 SNIP1
1
SNIP1 [nucleoplasm]
(R-HSA-3222315)
0.547
2
UniProt:P09429 HMGB1
5
HMGB1 [secretory granule lumen]
(R-HSA-6803337)
HMGB1 [ficolin-1-rich granule lumen]
(R-HSA-6803291)
HMGB1 [extracellular region]
(R-HSA-879382)
HMGB1 [nucleoplasm]
(R-HSA-266221)
HC23,45-HMGB1 [extracellular region]
(R-HSA-6797422)
0.527
2
UniProt:P55854 SUMO3
5
SUMO3(1-103) [nucleoplasm]
(R-HSA-2990830)
UBA2-G92-SUMO3 [nucleoplasm]
(R-HSA-3730627)
lysyl-G92-SUMOyl-K11-SUMO3 [nucleoplasm]
(R-HSA-9761547)
SUMO3 [nucleoplasm]
(R-HSA-2984269)
UBE2I-G92-SUMO3 [nucleoplasm]
(R-HSA-3730611)
0.524
2
UniProt:P14921 ETS1
2
ETS1 [nucleoplasm]
(R-HSA-1629809)
p-T38-ETS1 [nucleoplasm]
(R-HSA-3132720)
0.508
4
UniProt:Q85601 REX
0.488
2
UniProt:Q03060 CREM
0.488
2
UniProt:P0C206 REX
0.488
2
UniProt:P03410 TAX
0.488
2
UniProt:Q8AZK7 EBNA5
0.482
2
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