Scavenging by Class A Receptors

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R-HSA-3000480
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Pathway
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Homo sapiens
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Class A scavenger receptors contain an intracellular domain, a transmembrane region, a coiled-coil domain, a collagenous domain, and the SR cysteine-rich domain (reviewed in Areschoug and Gordon 2009, Bowdish and Gordon 2009). The coiled coil domains interact to form trimers. The collagenous domain (Rohrer et al. 1990, Acton et al. 1993) and/or the SR cysteine-rich domain (Brannstrom et al. 2002) bind ligands and determine the specificity of the receptor.

Literature References
PubMed ID Title Journal Year
19388903 Scavenger receptors: role in innate immunity and microbial pathogenesis

Areschoug, T, Gordon, S

Cell. Microbiol. 2009
8429029 The collagenous domains of macrophage scavenger receptors and complement component C1q mediate their similar, but not identical, binding specificities for polyanionic ligands

Acton, S, Resnick, D, Freeman, M, Ekkel, Y, Ashkenas, J, Krieger, M

J. Biol. Chem. 1993
2300208 Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II

Rohrer, L, Freeman, M, Kodama, T, Penman, M, Krieger, M

Nature 1990
11820786 Arginine residues in domain V have a central role for bacteria-binding activity of macrophage scavenger receptor MARCO

Brännström, A, Sankala, M, Tryggvason, K, Pikkarainen, T

Biochem. Biophys. Res. Commun. 2002
19120472 Conserved domains of the class A scavenger receptors: evolution and function

Bowdish, DM, Gordon, S

Immunol. Rev. 2009
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