Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-S473-PPP1R12A [nucleoplasm]
Stable Identifier
R-HSA-3002801
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S473-MYPT1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Regulation of PLK1 Activity at G2/M Transition (Homo sapiens)
Myosin phosphatase dephosphorylates PLK1 (Homo sapiens)
Phosphorylated Myosin Phosphatase [nucleoplasm] (Homo sapiens)
p-S473-PPP1R12A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14974 PPP1R12A
Gene Names
PPP1R12A, MBS, MYPT1
Chain
chain:1-1030
Reference Genes
BioGPS Gene:4659 PPP1R12A
COSMIC (genes):PPP1R12A PPP1R12A
CTD Gene:4659 PPP1R12A
dbSNP Gene:4659 PPP1R12A
ENSEMBL:ENSG00000058272 PPP1R12A
ENSEMBL_homo_sapiens_GENE:ENSG00000058272.19 PPP1R12A
HGNC:7618 PPP1R12A
KEGG Gene (Homo sapiens):4659 PPP1R12A
Monarch:4659 PPP1R12A
NCBI Gene:4659 PPP1R12A
OMIM:602021 PPP1R12A
UCSC:O14974 PPP1R12A
Reference Transcript
RefSeq:NM_001143885.1 PPP1R12A
RefSeq:NM_001143886.1 PPP1R12A
RefSeq:NM_002480.2 PPP1R12A
RefSeq:XM_011538383.2 PPP1R12A
RefSeq:NM_001244990.1 PPP1R12A
RefSeq:NM_001244992.1 PPP1R12A
Other Identifiers
11733074_s_at
11733075_a_at
11733076_x_at
11733077_a_at
11733078_a_at
16767932
201602_PM_s_at
201602_s_at
201603_PM_at
201603_at
201604_PM_s_at
201604_s_at
3463569
3463570
3463572
3463573
3463574
3463575
3463578
3463581
3463584
3463587
3463595
3463596
3463597
3463598
3463599
3463600
3463601
3463603
3463605
3463606
3463608
3463610
3463613
3463614
3463618
3463620
3463621
3463623
3463629
3463631
3463632
3463641
3463651
3463652
3463653
3463654
40438_at
4659
79022_at
7965123
A_23_P204564
A_24_P364412
A_24_P56252
GE499062
GE57421
GO:0000278
GO:0000776
GO:0001725
GO:0004857
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0006470
GO:0006913
GO:0007010
GO:0007098
GO:0007155
GO:0007165
GO:0015629
GO:0019208
GO:0019901
GO:0023052
GO:0030018
GO:0030155
GO:0031672
GO:0035507
GO:0035508
GO:0036211
GO:0043086
GO:0043226
GO:0043292
GO:0045944
GO:0046822
GO:0071466
GO:0071889
GO:0072357
GO:0098772
HMNXSV003029505
HMNXSV003055085
Hs.16533.0.S1_3p_a_at
Hs.16533.0.S3_3p_at
PH_hs_0024292
TC12001766.hg
g4505316_3p_a_at
Participates
as a component of
Phosphorylated Myosin Phosphatase [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T696,S852-PPP1R12A [cytosol]
PPP1R12A [cytosol]
p-T696-PPP1R12A [cytosol]
Inferred To
phospho-Ppp1r12a [nucleoplasm]
(Mus musculus)
phospho-Ppp1r12a [nucleoplasm]
(Rattus norvegicus)
phospho-mel-11 [nucleoplasm]
(Caenorhabditis elegans)
phospho-Mbs [nucleoplasm]
(Drosophila melanogaster)
phospho-PPP1R12A [nucleoplasm]
(Bos taurus)
phospho-PPP1R12A [nucleoplasm]
(Canis familiaris)
phospho-PPP1R12A [nucleoplasm]
(Gallus gallus)
phospho-PPP1R12A [nucleoplasm]
(Sus scrofa)
phospho-ppp1r12a [nucleoplasm]
(Danio rerio)
phospho-ppp1r12a [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 473
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001231919.1
,
NP_001137358.1
,
NP_002471.1
,
XP_011536685.1
,
NP_001137357.1
,
NP_001231921.1
OpenTargets
ENSG00000058272
HPA
ENSG00000058272-PPP1R12A
GeneCards
O14974
Ensembl
ENSP00000416769
,
ENST00000550107
,
ENSG00000058272
,
ENSP00000449514
,
ENST00000546369
,
ENSP00000261207
,
ENSP00000446855
,
ENST00000437004
,
ENST00000261207
,
ENSP00000389168
,
ENST00000450142
PRO
O14974
Pharos - Targets
O14974
PDB
2KJY
,
5HUZ
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
13
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.564
2
UniProt:O18734
2
phospho-CPI17 [cytosol]
(R-SSC-5671764)
CPI17 [cytosol]
(R-SSC-5671761)
0.544
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.483
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text