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HDAC5 [nucleoplasm]
Stable Identifier
R-HSA-3004533
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone deacetylase 5, HDAC5_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NICD1 PEST domain mutants displace co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Notch-HLH transcription pathway (Homo sapiens)
Formation of CSL NCOR corepressor complex (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
NR2E1 associated with transcription repressors binds PTEN promoter (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
HDAC3,5,7 [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
HDAC3,5,7 [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
HDAC3,5,7 [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7):PTEN Gene [nucleoplasm] (Homo sapiens)
NR2E1:(CoREST complex,ATN1,HDAC3,HDAC5,HDAC7) [nucleoplasm] (Homo sapiens)
CoREST complex,ATN1,HDAC3,5,7 [nucleoplasm] (Homo sapiens)
HDAC3,5,7 [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
NICD1 displaces co-repressor complex from RBPJ (CSL) (Homo sapiens)
NCOR:HDAC:TBL1 [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
RBPJ:NCOR corepressor complex [nucleoplasm] (Homo sapiens)
HDAC [nucleoplasm] (Homo sapiens)
HDAC5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UQL6 HDAC5
Gene Names
HDAC5, KIAA0600
Chain
chain:1-1122
Reference Genes
BioGPS Gene:10014 HDAC5
COSMIC (genes):HDAC5 HDAC5
CTD Gene:10014 HDAC5
dbSNP Gene:10014 HDAC5
ENSEMBL:ENSG00000108840 HDAC5
HGNC:14068 HDAC5
KEGG Gene (Homo sapiens):10014 HDAC5
Monarch:10014 HDAC5
NCBI Gene:10014 HDAC5
OMIM:605315 HDAC5
UCSC:Q9UQL6 HDAC5
Reference Transcript
RefSeq:XM_005256906.4 HDAC5
RefSeq:NM_005474.4 HDAC5
RefSeq:NM_001015053.1 HDAC5
Other Identifiers
0003990280
0003990364
0003990575
10014
11717036_a_at
11717037_a_at
16845537
19400
202455_at
229408_at
30991
3758843
3758844
3758846
3758847
3758848
3758850
3758852
3758853
3758854
3758855
3758857
3758859
3758860
3758863
3758864
3758865
3758866
3758867
3758869
3758871
3758872
3758873
3758874
3758875
3758876
3758877
3758878
3758879
3758880
3758881
3758882
3758885
3758886
3758887
3758888
3758890
3758891
3758892
3758893
3758894
3758908
3758915
3758916
3758917
3758918
3758919
38810_at
47794_at
5UWI
74391_at
8015914
A_23_P26916
A_23_P26922
A_24_P125283
A_32_P112359
AAC18040
AAD29047
AAH13140
AAH51824
AB011172
AC023855
AF039691
AF132608
BAA25526
BC013140
BC051824
BK000028
BX458255
CAB019400
CCDS32663
CCDS45696
DAA00017
ENSG00000108840
ENSP00000225983
ENSP00000337290
ENSP00000468004
ENST00000225983
ENST00000225983.10
ENST00000336057
ENST00000336057.9
ENST00000586802
ENST00000586802.5
EntrezGene:10014
EntrezGene:HDAC5
g13259520_3p_at
GE81517
GE88399
GO:0000118
GO:0000122
GO:0000978
GO:0001085
GO:0002376
GO:0003674
GO:0003677
GO:0003682
GO:0004407
GO:0005080
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005829
GO:0006325
GO:0006338
GO:0006342
GO:0006464
GO:0006476
GO:0006950
GO:0006954
GO:0008134
GO:0008150
GO:0009058
GO:0010830
GO:0010832
GO:0014823
GO:0016575
GO:0016607
GO:0016787
GO:0016810
GO:0019899
GO:0030154
GO:0030182
GO:0030183
GO:0032041
GO:0032869
GO:0032991
GO:0033558
GO:0034641
GO:0040011
GO:0040029
GO:0042113
GO:0042220
GO:0042493
GO:0042826
GO:0043167
GO:0043226
GO:0043393
GO:0044212
GO:0045892
GO:0045944
GO:0046872
GO:0048646
GO:0048856
GO:0048870
GO:0051091
GO:0051276
GO:0070491
GO:0070932
GO:0071222
GO:0090051
HDAC5
HDAC5-201
HDAC5-202
HDAC5-204
HGNC:14068
HPA030991
Hs.99969.1.A1_3p_at
ILMN_1810856
ILMN_2388166
IPR000286
IPR017320
IPR023696
IPR023801
IPR024643
IPR030703
IPR037138
K7EJL6
K7EJZ7
K7ES01
MIM:605315
NM_001015053
NM_005474
NP_001015053
NP_005465
PF00850
PF12203
PH_hs_0000951
PR01270
TC17001572.hg
UPI0000161FB3
UPI0000201355
UPI0000508BBA
XM_005256905
XM_005256906
XM_011524149
XM_011524150
XM_017023988
XM_017023989
XM_017023990
XM_017023991
XM_017023992
XM_017023993
XM_017023996
XP_005256962
XP_005256963
XP_011522451
XP_011522452
XP_016879477
XP_016879478
XP_016879479
XP_016879480
XP_016879481
XP_016879482
XP_016879485
Participant Of
hasMember
HDAC [nucleoplasm]
HDAC3,5,7 [nucleoplasm]
Inferred To
HDAC5 [nucleoplasm] (Bos taurus)
HDAC5 [nucleoplasm] (Canis familiaris)
HDAC5 [nucleoplasm] (Danio rerio)
HDAC5 [nucleoplasm] (Drosophila melanogaster)
HDAC5 [nucleoplasm] (Mus musculus)
HDAC5 [nucleoplasm] (Rattus norvegicus)
HDAC5 [nucleoplasm] (Schizosaccharomyces pombe)
HDAC5 [nucleoplasm] (Sus scrofa)
HDAC5 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_005465.2
,
XP_005256963.1
,
NP_001015053.1
ZINC - World Drugs
HDAC5_HUMAN
OpenTargets
ENSG00000108840
ZINC - FDA approved
HDAC5_HUMAN
ZINC - Substances
HDAC5_HUMAN
ZINC target
Q9UQL6
ZINC - Biogenic
HDAC5_HUMAN
PRO
Q9UQL6
PDB
5UWI
ZINC - Investigational
HDAC5_HUMAN
IntEnz
3.5.1.98
GeneCards
Q9UQL6
ZINC - Predictions - Purchasable
HDAC5_HUMAN
HMDB Protein
HMDBP09109
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.669
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.547
3
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.527
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
3
UniProt:Q13761 RUNX3
7
p-Y-RUNX3 [cytosol]
(R-HSA-8937805)
PolyUb-RUNX3 [nucleoplasm]
(R-HSA-8952417)
PolyUb-K94,K148-RUNX3 [nucleoplasm]
(R-HSA-8952387)
PolyUb-K94,K148-RUNX3 [cytosol]
(R-HSA-8952400)
Ac-K94,K171-RUNX3 [nucleoplasm]
(R-HSA-8951965)
RUNX3 [cytosol]
(R-HSA-8937797)
RUNX3 [nucleoplasm]
(R-HSA-8865393)
0.499
5
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