Reactome | HDAC5 [nucleoplasm]

HDAC5 [nucleoplasm]

Stable Identifier

R-HSA-3004533

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone deacetylase 5, HDAC5_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UQL6 HDAC5

Gene Names

HDAC5, KIAA0600

Chain

chain:1-1122

Reference Genes

BioGPS Gene:10014 HDAC5

COSMIC (genes):HDAC5 HDAC5

CTD Gene:10014 HDAC5

dbSNP Gene:10014 HDAC5

ENSEMBL:ENSG00000108840 HDAC5

HGNC:14068 HDAC5

KEGG Gene (Homo sapiens):10014 HDAC5

Monarch:10014 HDAC5

NCBI Gene:10014 HDAC5

OMIM:605315 HDAC5

UCSC:Q9UQL6 HDAC5

Reference Transcript

Other Identifiers

0003990280

0003990364

0003990575

10014

11717036_a_at

11717037_a_at

16845537

202455_at

229408_at

3758843

3758844

3758846

3758847

3758848

3758850

3758852

3758853

3758854

3758855

3758857

3758859

3758860

3758863

3758864

3758865

3758866

3758867

3758869

3758871

3758872

3758873

3758874

3758875

3758876

3758877

3758878

3758879

3758880

3758881

3758882

3758885

3758886

3758887

3758888

3758890

3758891

3758892

3758893

3758894

3758908

3758915

3758916

3758917

3758918

3758919

38810_at

47794_at

74391_at

8015914

A_23_P26916

A_23_P26922

A_24_P125283

A_32_P112359

GE81517

GE88399

GO:0000118

GO:0000122

GO:0000976

GO:0000978

GO:0001085

GO:0002376

GO:0003674

GO:0003677

GO:0003682

GO:0004407

GO:0005080

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0006325

GO:0006338

GO:0006342

GO:0006464

GO:0006476

GO:0006950

GO:0006954

GO:0008134

GO:0008150

GO:0009058

GO:0010830

GO:0010832

GO:0014823

GO:0016575

GO:0016607

GO:0016787

GO:0016810

GO:0019899

GO:0030154

GO:0030182

GO:0030183

GO:0032041

GO:0032869

GO:0032991

GO:0033558

GO:0034641

GO:0040011

GO:0040029

GO:0042113

GO:0042220

GO:0042493

GO:0042802

GO:0042826

GO:0043167

GO:0043226

GO:0043393

GO:0045892

GO:0045944

GO:0046872

GO:0048646

GO:0048856

GO:0048870

GO:0051091

GO:0051276

GO:0070491

GO:0070932

GO:0071222

GO:0090051

Hs.99969.1.A1_3p_at

ILMN_1810856

ILMN_2388166

PH_hs_0000951

TC17001572.hg

g13259520_3p_at

Participant Of

hasMember

Inferred To

HDAC5 [nucleoplasm] (Canis familiaris)

HDAC5 [nucleoplasm] (Sus scrofa)

hdac5 [nucleoplasm] (Danio rerio)

HDAC4 [nucleoplasm] (Drosophila melanogaster)

Hdac5 [nucleoplasm] (Mus musculus)

Hdac5 [nucleoplasm] (Rattus norvegicus)

wdr35 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001015053.1, XP_005256963.1, NP_005465.2

ZINC - World Drugs

HDAC5_HUMAN

OpenTargets

ENSG00000108840

ZINC - FDA approved

HDAC5_HUMAN

ZINC - Substances

HDAC5_HUMAN

ZINC - Biogenic

HDAC5_HUMAN

ZINC target

Q9UQL6

PRO

Q9UQL6

PDB

5UWI

ZINC - Investigational

HDAC5_HUMAN

IntEnz

3.5.1.98

HPA

ENSG00000108840-HDAC5

GeneCards

Q9UQL6

Ensembl

ENST00000225983, ENSP00000225983, ENSG00000108840, ENST00000586802, ENST00000336057, ENSP00000337290, ENSP00000468004

ZINC - Predictions - Purchasable

HDAC5_HUMAN

HMDB Protein

HMDBP09109

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.669	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.547	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2
UniProt:Q13761 RUNX3	7	RUNX3 [cytosol] (R-HSA-8937797) RUNX3 [nucleoplasm] (R-HSA-8865393) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417)	0.499	5

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