Reactome | HDAC7 [nucleoplasm]

HDAC7 [nucleoplasm]

Stable Identifier

R-HSA-3004534

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone deacetylase 7, HDAC7_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        UBE2I, HDAC7 SUMOylate PML with SUMO1 (Homo sapiens)
        
        UBE2I,HDAC7 [nucleoplasm] (Homo sapiens)
        
        HDAC7 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WUI4 HDAC7

Gene Names

HDAC7, HDAC7A

Chain

chain:1-952

Reference Genes

BioGPS Gene:51564 HDAC7

COSMIC (genes):HDAC7 HDAC7

CTD Gene:51564 HDAC7

dbSNP Gene:51564 HDAC7

ENSEMBL:ENSG00000061273 HDAC7

HGNC:14067 HDAC7

KEGG:hsa:51564 HDAC7

Monarch:51564 HDAC7

NCBI Gene:51564 HDAC7

OMIM:606542 HDAC7

UCSC:Q8WUI4 HDAC7

Reference Transcript

Participates

as a member of

Inferred To

hda-4 [nucleoplasm] (Caenorhabditis elegans)

hdaD [nucleoplasm] (Dictyostelium discoideum)

Homologues of HDAC7 [nucleoplasm] (Dictyostelium discoideum)

HDAC7 [nucleoplasm] (Bos taurus)

HDAC7 [nucleoplasm] (Canis familiaris)

HDAC7 [nucleoplasm] (Dictyostelium discoideum)

HDAC7 [nucleoplasm] (Drosophila melanogaster)

HDAC7 [nucleoplasm] (Gallus gallus)

HDAC7 [nucleoplasm] (Mus musculus)

HDAC7 [nucleoplasm] (Sus scrofa)

HDAC7 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001091886.1, XP_011536784.1, NP_056216.2, XP_011536783.1, NP_001295019.1

Guide to Pharmacology - Targets

2661

OpenTargets

ENSG00000061273

ENSEMBL

ENSP00000404394, ENSG00000061273, ENSP00000080059, ENST00000080059, ENSP00000351326, ENST00000552960, ENST00000427332, ENSP00000448532, ENST00000354334

ZINC - FDA approved

HDAC7_HUMAN

ZINC - Substances

HDAC7_HUMAN

ZINC - Biogenic

HDAC7_HUMAN

ZINC target

Q8WUI4

PRO

Q8WUI4

GlyGen

Q8WUI4

PDB

3C10, 8Q9Q, 3C0Y, 3C0Z, 3ZNR, 3ZNS

ZINC - Investigational

HDAC7_HUMAN

HPA

ENSG00000061273-HDAC7

GeneCards

HDAC7

Pharos - Targets

Q8WUI4

ZINC - Predictions - Purchasable

HDAC7_HUMAN

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.802	5
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.688	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.643	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:Q8CFN5 Mef2c	3	Mef2c [nucleoplasm] (R-MMU-199938) Mef2c [nucleoplasm] (R-MMU-1605569) phospho-Mef2c [nucleoplasm] (R-MMU-448838)	0.499	2