Reactome | HMGA1 [nucleoplasm]

HMGA1 [nucleoplasm]

Stable Identifier

R-HSA-3004623

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

High mobility group protein HMG-I/HMG-Y, HMGA1_HUMAN, HMGI/Y

Locations in the PathwayBrowser for interactor UniProt:O75367 H2AY

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
      - Formation of Senescence-Associated Heterochromatin Foci (SAHF) (Homo sapiens)
        
        SAHF formation (Homo sapiens)
        
        HMGA1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P17096 HMGA1

Gene Names

HMGA1, HMGIY

Chain

initiator methionine:, chain:2-107

Reference Genes

BioGPS Gene:3159 HMGA1

COSMIC (genes):HMGA1 HMGA1

CTD Gene:3159 HMGA1

dbSNP Gene:3159 HMGA1

ENSEMBL:ENSG00000137309 HMGA1

HGNC:5010 HMGA1

KEGG:hsa:3159 HMGA1

Monarch:3159 HMGA1

NCBI Gene:3159 HMGA1

OMIM:600701 HMGA1

UCSC:P17096 HMGA1

Reference Transcript

Participates

as a component of

as an input of

SAHF formation (Homo sapiens)

Other forms of this molecule

HMGA1 [cytosol]

Inferred To

HMGA1 [nucleoplasm] (Canis familiaris)

HMGA1 [nucleoplasm] (Sus scrofa)

hmg-12 [nucleoplasm] (Caenorhabditis elegans)

Hmga1 [nucleoplasm] (Mus musculus)

Cross References

OpenTargets

ENSG00000137309

ENSEMBL

ENST00000311487, ENSP00000288245, ENSP00000399888, ENST00000401473, ENST00000447654, ENST00000374116, ENSP00000385693, ENSP00000308227, ENST00000347617, ENSG00000137309, ENSP00000363230

HPA

ENSG00000137309-HMGA1

GeneCards

HMGA1

PRO

P17096

Pharos - Targets

P17096

GlyGen

P17096

PDB

2EZG, 2EZF, 2EZD, 2EZE, 8CPG

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IUE6 H2AC21	11	AcK-HIST2H2AB [nucleoplasm] (R-HSA-4551335) HIST2H2AB [nucleoplasm] (R-HSA-4549212) MeR12-HIST2H2AB [nucleoplasm] (R-HSA-5229207) Me2aR12-HIST2H2AB [nucleoplasm] (R-HSA-5229314) MeR4-HIST2H2AB [nucleoplasm] (R-HSA-5244632) Me2aR4-HIST2H2AB [nucleoplasm] (R-HSA-5244588) MeR30-HIST2H2AB [nucleoplasm] (R-HSA-5244540) Me2aR30-HIST2H2AB [nucleoplasm] (R-HSA-5244567) AcK6-HIST2H2AB [nucleoplasm] (R-HSA-4568609) Ub-HIST2H2AB [nucleoplasm] (R-HSA-6782490) K63polyUb-HIST2H2AB [nucleoplasm] (R-HSA-6783295)	0.669	3
UniProt:Q9Y5N6 ORC6	4	ORC6 [nucleoplasm] (R-HSA-68539) ORC6 [cytosol] (R-HSA-9734663) p-T195-ORC6 [cytosol] (R-HSA-9734682) p-T195-ORC6 [nucleoplasm] (R-HSA-9734715)	0.602	4
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.564	2
UniProt:Q16778 H2BC21	9	HIST2H2BE [nucleoplasm] (R-HSA-181908) Ub-121-HIST2H2BE [nucleoplasm] (R-HSA-3364018) AcK16-HIST2H2BE [nucleoplasm] (R-HSA-4568660) AcK6-HIST2H2BE [nucleoplasm] (R-HSA-4568679) AcK21-HIST2H2BE [nucleoplasm] (R-HSA-4568716) AcK13-HIST2H2BE [nucleoplasm] (R-HSA-4568651) HIST2H2BE [extracellular region] (R-HSA-977571) Ack-HIST2H2BE [nucleoplasm] (R-HSA-4549257) Ub-HIST2H2BE [nucleoplasm] (R-HSA-6782539)	0.564	2
UniProt:P16402 H1-3	1	HIST1H1D [nucleoplasm] (R-HSA-211241)	0.564	2
UniProt:P08047 SP1	1	SP1 [nucleoplasm] (R-HSA-1592223)	0.544	4
UniProt:P17676 CEBPB	3	p-T235, S321-CEBPB [nucleoplasm] (R-HSA-3857339) p-T235-CEBPB [nucleoplasm] (R-HSA-3857343) CEBPB [nucleoplasm] (R-HSA-381378)	0.544	3
UniProt:O75367 H2AY			0.527	2
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) p-S-BMI1 [nucleoplasm] (R-HSA-3229116) monoSUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.527	2
IntAct:EBI-1566868 IL2RA			0.525	3

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