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Hyp-K50-EIF5A [cytosol]
Stable Identifier
R-HSA-3006310
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Eukaryotic translation initiation factor 5A, IF5A1_HUMAN, Hyp50
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Homo sapiens)
Hypusine synthesis from eIF5A-lysine (Homo sapiens)
DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A (Homo sapiens)
Hyp-K50-EIF5A [cytosol] (Homo sapiens)
Hyp-K50-EIF5A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63241 EIF5A
Gene Names
EIF5A
Chain
initiator methionine:1, chain:2-154
Reference Genes
BioGPS Gene:1984 EIF5A
COSMIC (genes):EIF5A EIF5A
CTD Gene:1984 EIF5A
dbSNP Gene:1984 EIF5A
ENSEMBL:ENSG00000132507 EIF5A
ENSEMBL:ENSG00000288145 EIF5A
HGNC:3300 EIF5A
KEGG Gene (Homo sapiens):1984 EIF5A
Monarch:1984 EIF5A
NCBI Gene:1984 EIF5A
OMIM:600187 EIF5A
UCSC:P63241 EIF5A
Reference Transcript
RefSeq:NM_001143762.1 EIF5A
RefSeq:NM_001143761.1 EIF5A
RefSeq:NM_001143760.1 EIF5A
RefSeq:XM_005256509.2 EIF5A
RefSeq:NM_001970.4 EIF5A
Other Identifiers
0002100097
11737958_x_at
11744682_x_at
11753619_s_at
11758734_x_at
1984
201122_x_at
201123_s_at
213753_3p_x_at
213753_x_at
3253922
3253923
3253924
3253925
3253929
3253930
3253931
3253932
3297606
3297607
3297608
3297610
3708423
3708424
3708425
3708426
3708427
3708428
3708429
3708430
3708432
3708435
3708437
3708439
3708441
3708442
3708443
7928600
7928630
7934753
A_24_P31235
GE79692
GE88537
GO:0003674
GO:0003723
GO:0003746
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005642
GO:0005643
GO:0005737
GO:0005783
GO:0005789
GO:0005829
GO:0006406
GO:0006412
GO:0006414
GO:0006611
GO:0006810
GO:0006913
GO:0006915
GO:0008135
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009058
GO:0015031
GO:0016020
GO:0017070
GO:0032991
GO:0034641
GO:0043022
GO:0043226
GO:0045901
GO:0045905
GO:0047485
GO:0051028
Hs.119140.1.S1_3p_x_at
ILMN_1794522
S72024_s_at
TC17000088.hg
g4503544_3p_a_at
Participant Of
hasMember
Hyp-K50-EIF5A [cytosol]
Other forms of this molecule
EIF5A [cytosol]
Dhp-K50-EIF5A [cytosol]
Inferred To
eEF5 [cytosol] (Drosophila melanogaster)
tif51b [cytosol] (Schizosaccharomyces pombe)
Homologues of Hyp-K50-EIF5A [cytosol] (Schizosaccharomyces pombe)
iff-2 [cytosol] (Caenorhabditis elegans)
tif51a [cytosol] (Schizosaccharomyces pombe)
Eif5a [cytosol] (Mus musculus)
Eif5a [cytosol] (Rattus norvegicus)
EIF5A [cytosol] (Canis familiaris)
ANB1 [cytosol] (Saccharomyces cerevisiae)
Hyp-K50-EIF5A [cytosol] (Bos taurus)
Hyp-K50-EIF5A [cytosol] (Gallus gallus)
Hyp-K50-EIF5A [cytosol] (Plasmodium falciparum)
Hyp-K50-EIF5A [cytosol] (Sus scrofa)
eif5a [cytosol] (Danio rerio)
eif5a [cytosol] (Dictyostelium discoideum)
eif5a [cytosol] (Xenopus tropicalis)
Modified Residues
Name
hypusine at 50
Coordinate
50
PsiMod Name
hypusine [MOD:00125]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
Cross References
RefSeq
NP_001961.1
,
NP_001137234.1
,
NP_001137232.1
,
NP_001137233.1
,
XP_005256566.1
Target Pathogen
5b354852be737e166372e8a5
OpenTargets
ENSG00000132507
GeneCards
P63241
HPA
ENSG00000132507-EIF5A
Ensembl
ENST00000672755
,
ENSG00000132507
,
ENSP00000390677
,
ENST00000571955
,
ENST00000416016
,
ENST00000573542
,
ENST00000673304
,
ENSP00000459611
,
ENSP00000458269
,
ENST00000576930
,
ENSP00000396073
,
ENST00000672765
,
ENST00000672250
,
ENSG00000288145
,
ENSP00000500847
,
ENST00000673259
,
ENSP00000336702
,
ENSP00000500624
,
ENSP00000500669
,
ENST00000673099
,
ENSP00000500717
,
ENST00000336452
,
ENSP00000459196
,
ENSP00000500414
,
ENST00000419711
,
ENSP00000336776
,
ENSP00000499995
,
ENSP00000499855
,
ENST00000336458
,
ENST00000673210
PRO
P63241
HMDB Protein
HMDBP02415
PDB
3CPF
,
5DLQ
,
1FH4
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00560 SDCBP
3
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.556
3
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