Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SMAD6 [cytosol]
Stable Identifier
R-HSA-3006350
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Mothers against decapentaplegic homolog 6, SMAD6_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
RUNX2 regulates bone development (Homo sapiens)
SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-Smad competes with Co-Smad for R-Smad1/5/8 (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-SMAD:p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
I-SMAD [cytosol] (Homo sapiens)
SMAD6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43541 SMAD6
Gene Names
SMAD6, MADH6
Chain
chain:1-496
Reference Genes
COSMIC (genes):SMAD6 SMAD6
dbSNP Gene:4091 SMAD6
ENSEMBL:ENSG00000137834 SMAD6
Participates
as a member of
I-SMAD [cytosol] (Homo sapiens)
as an output of
SMAD6 gene expression is stimulated by RUNX2 and SMAD1 (Homo sapiens)
Inferred To
tag-68 [cytosol]
(Caenorhabditis elegans)
Smad6 [cytosol]
(Rattus norvegicus)
SMAD6 [cytosol]
(Bos taurus)
SMAD6 [cytosol]
(Canis familiaris)
SMAD6 [cytosol]
(Gallus gallus)
SMAD6 [cytosol]
(Mus musculus)
SMAD6 [cytosol]
(Sus scrofa)
smad6b [cytosol]
(Danio rerio)
Dad [cytosol]
(Drosophila melanogaster)
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51817 PRKX
1
PRKX [nucleoplasm]
(R-HSA-3222308)
0.633
5
UniProt:Q15797 SMAD1
4
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
SMAD1 [cytosol]
(R-HSA-201468)
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
0.567
4
UniProt:O43541 SMAD6
1
SMAD6 [cytosol]
(R-HSA-3006350)
0.508
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text