Reactome | ITGB3BP [cytosol]

ITGB3BP [cytosol]

Stable Identifier

R-HSA-3006405

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Centromere protein R, CENPR_HUMAN, NRIF, Nuclear receptor-interacting factor 3

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Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        CCAN network [cytosol] (Homo sapiens)
        
        CENP-O complex [cytosol] (Homo sapiens)
        
        ITGB3BP [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13352 ITGB3BP

Gene Names

ITGB3BP, CENPR, NRIF3

Chain

chain:1-177

Reference Genes

BioGPS Gene:23421 ITGB3BP

COSMIC (genes):ITGB3BP ITGB3BP

CTD Gene:23421 ITGB3BP

dbSNP Gene:23421 ITGB3BP

ENSEMBL:ENSG00000142856 ITGB3BP

HGNC:6157 ITGB3BP

KEGG:hsa:23421 ITGB3BP

Monarch:23421 ITGB3BP

NCBI Gene:23421 ITGB3BP

OMIM:605494 ITGB3BP

UCSC:Q13352 ITGB3BP

Reference Transcript

Participates

as an input of

as an output of

gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)

as a component of

Other forms of this molecule

ITGB3BP [nucleoplasm]

Inferred To

Ghost homologue of ITGB3BP [cytosol] (Danio rerio)

Ghost homologue of ITGB3BP [cytosol] (Sus scrofa)

Ghost homologue of ITGB3BP [cytosol] (Xenopus tropicalis)

ITGB3BP [cytosol] (Bos taurus)

ITGB3BP [cytosol] (Canis familiaris)

ITGB3BP [cytosol] (Gallus gallus)

Itgb3bp [cytosol] (Mus musculus)

Itgb3bp [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001334077.1, NP_055103.3, NP_001193668.1

OpenTargets

ENSG00000142856

ENSEMBL

ENST00000489099, ENSP00000360133, ENSP00000432904, ENST00000271002, ENST00000371092, ENSP00000271002, ENSG00000142856

GeneCards

ITGB3BP

HPA

ENSG00000142856-ITGB3BP

PRO

Q13352

Pharos - Targets

Q13352

GlyGen

Q13352

HMDB Protein

HMDBP01805

PDB

7XHN, 7PKN, 7XHO, 7YWX, 7QOO, 7R5S, 7YYH, 7R5V, 7PB8

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.666	4
UniProt:Q9Y5P4 CERT1			0.666	4
UniProt:Q8WWB5 PIHD2			0.666	7
UniProt:Q71F23 CENPU	2	MLF1IP [nucleoplasm] (R-HSA-606309) MLF1IP [cytosol] (R-HSA-375315)	0.623	5
UniProt:P14927 UQCRB	1	UQCRB [mitochondrial inner membrane] (R-HSA-164287)	0.556	3
UniProt:A6NI15 MSGN1	1	MSGN1 [nucleoplasm] (R-HSA-9793376)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:Q969Y2 GTPBP3	1	GTPBP3 [mitochondrial matrix] (R-HSA-6787414)	0.556	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.556	3
UniProt:Q00613 HSF1	11	HSF1 [cytosol] (R-HSA-3371452) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) hC36,103-HSF1 [cytosol] (R-HSA-4793916) HSF1 [nucleoplasm] (R-HSA-5082385) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906)	0.556	3
UniProt:O14901 KLF11			0.556	6
UniProt:O14645 IDLC			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:X5D778 X5D778			0.556	3
UniProt:Q6ICG6-3 KIAA0930			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:P50440 GATM	1	GATM [mitochondrial intermembrane space] (R-HSA-71267)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q96AL5 Q96AL5			0.556	3
UniProt:Q13449 LSAMP	2	cleaved GPI-LSAMP [extracellular region] (R-HSA-8941032) GPI-LSAMP [plasma membrane] (R-HSA-8940809)	0.556	3
UniProt:P01112 HRAS	20	S-Farn-Me-2xPalmS HRAS [plasma membrane] (R-HSA-9647912) HRAS [plasma membrane] (R-HSA-62717) S-Farn-HRAS [endoplasmic reticulum membrane] (R-HSA-9647788) S-Farn-Me HRAS [endoplasmic reticulum membrane] (R-HSA-9647796) S-Farn-proHRAS [endoplasmic reticulum membrane] (R-HSA-9647918) proHRAS [cytosol] (R-HSA-9647765) S-Farn-Me PalmS HRAS [Golgi membrane] (R-HSA-9647896) S-Farn-Me HRAS [plasma membrane] (R-HSA-9665052) HRAS G12C [plasma membrane] (R-HSA-9656561) HRAS G12D [plasma membrane] (R-HSA-9656564) HRAS K117N [plasma membrane] (R-HSA-9656603) HRAS G13S [plasma membrane] (R-HSA-9656574) HRAS G13D [plasma membrane] (R-HSA-9656572) HRAS G13V [plasma membrane] (R-HSA-9656579) HRAS K117R [plasma membrane] (R-HSA-9656010) HRAS G13C [plasma membrane] (R-HSA-9656008) HRAS T58I [plasma membrane] (R-HSA-9656014) HRAS G12S [plasma membrane] (R-HSA-6802343) HRAS G12V [plasma membrane] (R-HSA-6802350) HRAS G13R [plasma membrane] (R-HSA-6802368)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:P62491 RAB11A	4	GGC-RAB11A [cytoplasmic vesicle membrane] (R-HSA-1458519) RAB11A [cytosol] (R-HSA-5623395) GGC-RAB11A [cytosol] (R-HSA-8873781) RAB11A [recycling endosome membrane] (R-HSA-2029023)	0.556	3
UniProt:Q5JVL4 EFHC1			0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:O75971-2 SNAPC5			0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.556	3
UniProt:Q9BVL2 NUP58			0.556	6
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) MAPK9 [cytosol] (R-HSA-450355)	0.556	3
UniProt:Q9Y2K6 USP20	1	USP20 [cytosol] (R-HSA-5696946)	0.556	3
UniProt:P51687 SUOX	1	SUOX [mitochondrial matrix] (R-HSA-1614570)	0.556	3
UniProt:O14770-4 MEIS2			0.556	3
UniProt:Q8N7C3 TRIMM			0.556	3
UniProt:Q9H7Z3 NRDE2			0.556	3
UniProt:Q9NWQ9 CN119			0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q7L2Z9 CENPQ	2	CENPQ [nucleoplasm] (R-HSA-606327) CENPQ [cytosol] (R-HSA-375298)	0.527	3
UniProt:Q9BU64 CENPO	2	CENPO [nucleoplasm] (R-HSA-606317) CENPO [cytosol] (R-HSA-375301)	0.527	4
UniProt:Q6IPU0 CENPP	2	CENPP [nucleoplasm] (R-HSA-606341) CENPP [cytosol] (R-HSA-375299)	0.527	4