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ITSN1 [cytosol]
Stable Identifier
R-HSA-3006481
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Intersectin-1, ITSN1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O00401
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
EPHB binds ITSN1 (Homo sapiens)
ITSN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15811 ITSN1
Gene Names
ITSN1, ITSN, SH3D1A
Chain
chain:1-1721
Reference Genes
BioGPS Gene:6453 ITSN1
COSMIC (genes):ITSN1 ITSN1
CTD Gene:6453 ITSN1
dbSNP Gene:6453 ITSN1
ENSEMBL:ENSG00000205726 ITSN1
HGNC:6183 ITSN1
KEGG Gene (Homo sapiens):6453 ITSN1
Monarch:6453 ITSN1
NCBI Gene:6453 ITSN1
OMIM:602442 ITSN1
UCSC:Q15811 ITSN1
Reference Transcript
RefSeq:NM_001331009.1 ITSN1
RefSeq:XM_017028433.1 ITSN1
RefSeq:NM_001331012.1 ITSN1
RefSeq:XM_017028428.1 ITSN1
RefSeq:XM_017028440.1 ITSN1
RefSeq:NM_001331011.1 ITSN1
RefSeq:NM_001001132.1 ITSN1
RefSeq:XM_011529693.2 ITSN1
RefSeq:NM_003024.2 ITSN1
RefSeq:NM_001331010.1 ITSN1
RefSeq:XM_011529692.1 ITSN1
RefSeq:XM_017028432.1 ITSN1
Other Identifiers
11722550_a_at
11722551_s_at
11722552_x_at
11736139_at
11736140_a_at
11736141_a_at
11745505_x_at
11746778_a_at
11750609_a_at
11759181_at
11760588_at
1557279_at
1557280_s_at
16922327
207322_at
209297_at
209298_s_at
230042_at
2848453
2848455
2848457
2848460
35776_at
3918780
3918790
3918791
3918792
3918793
3918796
3918805
3918806
3918807
3918810
3918811
3918813
3918814
3918815
3918817
3918818
3918820
3918821
3918823
3918824
3918826
3918827
3918829
3918831
3918834
3918836
3918843
3918845
3918846
3918853
3918855
3918861
3918865
3918866
3918867
3918868
3918869
3918870
3918871
3918881
3918884
3918890
3918896
3918898
3918903
3918904
3918905
3918906
3918907
3918908
3918909
3918910
3918911
3918912
3918913
3918914
3918915
3918916
3918917
3918918
3918919
3918920
3918921
3918937
3918939
3918941
488_at
4898019C_3p_x_at
55412_at
6453
8068305
A_14_P104004
A_14_P116756
A_23_P252962
A_23_P91504
A_24_P111061
A_24_P918500
A_33_P3250595
A_33_P3277728
GE54587
GE736570
GE79207
GE84040
GE88249
GO:0003674
GO:0005085
GO:0005509
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0005905
GO:0006810
GO:0006887
GO:0006897
GO:0007165
GO:0007186
GO:0007264
GO:0007267
GO:0007420
GO:0008150
GO:0008219
GO:0012505
GO:0015031
GO:0016020
GO:0016032
GO:0016192
GO:0016197
GO:0019209
GO:0019899
GO:0030027
GO:0030054
GO:0030139
GO:0030154
GO:0030234
GO:0031410
GO:0033674
GO:0034330
GO:0034613
GO:0035556
GO:0042995
GO:0043005
GO:0043025
GO:0043065
GO:0043167
GO:0043197
GO:0043226
GO:0043524
GO:0044305
GO:0044403
GO:0045202
GO:0046872
GO:0048013
GO:0048488
GO:0048856
GO:0051056
GO:0051897
GO:0055037
GO:0060090
GO:0060124
GO:0060999
GO:0061024
GO:0070064
GO:0097440
GO:0097708
GO:0098833
GO:0098978
GO:0150007
GO:1905274
GO:2001288
Hs.90221.0.A1_3p_at
Hs.90221.0.A1_3p_x_at
Hs2.407005.1.S1_3p_s_at
ILMN_1651848
ILMN_1672741
ILMN_1718769
ILMN_1861392
PH_hs_0005037
PH_hs_0035443
TC21000131.hg
TC21000681.hg
TC21000683.hg
TC21000684.hg
TC21000685.hg
g4504796_3p_at
g4808824_3p_s_at
Participant Of
hasMember
GEFs [cytosol]
ITSNs [cytosol]
input
EPHB binds ITSN1
hasComponent
ITSN1:N-WASP [cytosol]
p-EPHBs:EFNBs:ITSN1 [plasma membrane]
Inferred To
Homologues of ITSN1 [cytosol] (Saccharomyces cerevisiae)
Homologues of ITSN1 [cytosol] (Schizosaccharomyces pombe)
Itsn1 [cytosol] (Mus musculus)
Itsn1 [cytosol] (Rattus norvegicus)
ITSN1 [cytosol] (Canis familiaris)
ITSN1 [cytosol] (Gallus gallus)
ITSN1 [cytosol] (Schizosaccharomyces pombe)
Dap160 [cytosol] (Drosophila melanogaster)
itsn1 [cytosol] (Danio rerio)
rps6ka1 [cytosol] (Xenopus tropicalis)
itsn-1 [cytosol] (Caenorhabditis elegans)
pan1 [cytosol] (Schizosaccharomyces pombe)
PAN1 [cytosol] (Saccharomyces cerevisiae)
Ghost homologue of ITSN1 [cytosol] (Sus scrofa)
end3 [cytosol] (Schizosaccharomyces pombe)
END3 [cytosol] (Saccharomyces cerevisiae)
Cross References
RefSeq
XP_016883922.1
,
XP_016883921.1
,
NP_001317940.1
,
XP_011527995.1
,
XP_016883917.1
,
XP_016883929.1
,
NP_001317941.1
,
NP_001317939.1
,
XP_011527994.1
,
NP_003015.2
,
NP_001001132.1
,
NP_001317938.1
OpenTargets
ENSG00000205726
GeneCards
Q15811
HPA
ENSG00000205726-ITSN1
Ensembl
ENST00000399353
,
ENST00000399352
,
ENSP00000370691
,
ENSP00000382286
,
ENST00000381291
,
ENSP00000382275
,
ENSP00000382290
,
ENSP00000370719
,
ENSP00000382301
,
ENSP00000382289
,
ENST00000399349
,
ENST00000399338
,
ENST00000381318
,
ENST00000399367
,
ENSG00000205726
PRO
Q15811
Orphanet
28565
PDB
4IIM
,
5HZJ
,
3FIA
,
5HZK
,
5HZI
,
6H5T
,
6GBU
,
1KI1
,
2KHN
,
2KGR
,
3QBV
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P22681 CBL
39
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL del366-409 [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL R499* [cytosol]
(R-HSA-9706670)
CBL H398R [cytosol]
(R-HSA-9706638)
CBL H398P [cytosol]
(R-HSA-9706637)
CBL G375fs*16 [cytosol]
(R-HSA-9706211)
CBL R420* [cytosol]
(R-HSA-9706208)
CBL H398D [cytosol]
(R-HSA-9706631)
CBL Y371C [cytosol]
(R-HSA-9706694)
CBL G375S [cytosol]
(R-HSA-9706214)
CBL Y371D [cytosol]
(R-HSA-9706687)
CBL Y371S [cytosol]
(R-HSA-9706674)
CBL P417S [cytosol]
(R-HSA-9706642)
CBL H398N [cytosol]
(R-HSA-9706641)
CBL R420P [cytosol]
(R-HSA-9706193)
CBL Y371N [cytosol]
(R-HSA-9706679)
CBL R499Q [cytosol]
(R-HSA-9706677)
CBL R420L [cytosol]
(R-HSA-9706197)
CBL P417H [cytosol]
(R-HSA-9706644)
p-Y371-CBL [plasma membrane]
(R-HSA-182923)
p-Y-CBL [cytosol]
(R-HSA-8875457)
p-Y371-CBL [cytosol]
(R-HSA-182940)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
CBL [cytosol]
(R-HSA-112199)
0.729
12
UniProt:P50570 DNM2
5
DNM2 [plasma membrane]
(R-HSA-2984201)
DNM2 [Golgi membrane]
(R-HSA-2980842)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
0.713
3
UniProt:O00401 WASL
4
N-WASP [cytosol]
(R-HSA-201873)
p-Y256-WASL [cytosol]
(R-HSA-2197672)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.704
5
UniProt:Q07889 SOS1
3
SOS1 [plasma membrane]
(R-HSA-983559)
p-4S-SOS1 [cytosol]
(R-HSA-109821)
SOS1 [cytosol]
(R-HSA-64847)
0.636
7
UniProt:Q05193 DNM1
3
DNM1 [cytosol]
(R-HSA-2213182)
DNM1 [lysosomal membrane]
(R-HSA-196150)
DNM1 [plasma membrane]
(R-HSA-177488)
0.623
3
UniProt:P42566 EPS15
2
p-Y850 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.564
3
UniProt:Q3UQN2
1
Fcho2 [cytosol]
(R-MMU-8862260)
0.557
3
UniProt:Q9NRI5 DISC1
0.553
4
UniProt:P60953-1 CDC42
0.544
2
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