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ITSN1 [cytosol]
Stable Identifier
R-HSA-3006481
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Intersectin-1, ITSN1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q07889 SOS1
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
EPHB binds ITSN1 (Homo sapiens)
ITSN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15811 ITSN1
Gene Names
ITSN1, ITSN, SH3D1A
Chain
chain:1-1721
Reference Genes
COSMIC (genes):ITSN1 ITSN1
dbSNP Gene:6453 ITSN1
ENSEMBL:ENSG00000205726 ITSN1
Participates
as a member of
ITSNs [cytosol] (Homo sapiens)
RHOG GEFs [cytosol] (Homo sapiens)
RHOQ GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
as an input of
EPHB binds ITSN1 (Homo sapiens)
as a component of
p-EPHBs:EFNBs:ITSN1 [plasma membrane] (Homo sapiens)
ITSN1:N-WASP [cytosol] (Homo sapiens)
Inferred To
Homologues of ITSN1 [cytosol]
(Canis familiaris)
Homologues of ITSN1 [cytosol]
(Plasmodium falciparum)
Homologues of ITSN1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of ITSN1 [cytosol]
(Schizosaccharomyces pombe)
ITSN1 [cytosol]
(Bos taurus)
ITSN1 [cytosol]
(Canis familiaris)
ITSN1 [cytosol]
(Gallus gallus)
ITSN1 [cytosol]
(Mus musculus)
ITSN1 [cytosol]
(Plasmodium falciparum)
ITSN1 [cytosol]
(Rattus norvegicus)
ITSN1 [cytosol]
(Saccharomyces cerevisiae)
ITSN1 [cytosol]
(Schizosaccharomyces pombe)
ITSN1 [cytosol]
(Sus scrofa)
Dap160 [cytosol]
(Drosophila melanogaster)
LOC119867035 [cytosol]
(Canis familiaris)
itsn-1 [cytosol]
(Caenorhabditis elegans)
pan1 [cytosol]
(Schizosaccharomyces pombe)
ucp8 [cytosol]
(Schizosaccharomyces pombe)
Ghost homologue of ITSN1 [cytosol]
(Danio rerio)
IRS4 [cytosol]
(Saccharomyces cerevisiae)
end3 [cytosol]
(Schizosaccharomyces pombe)
eps15 [cytosol]
(Dictyostelium discoideum)
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63010 AP2B1
4
AP2B1 [endolysosome membrane]
(R-HSA-6784827)
AP2B1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130489)
AP2B1 [cytosol]
(R-HSA-182166)
AP2B1 [plasma membrane]
(R-HSA-167690)
0.764
5
UniProt:Q9UBC2 EPS15L1
2
EPS15L1 [plasma membrane]
(R-HSA-182937)
EPS15L1 [cytosol]
(R-HSA-8935900)
0.738
5
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL [cytosol]
(R-HSA-112199)
p-Y371-CBL [cytosol]
(R-HSA-182940)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
0.729
12
UniProt:Q07889 SOS1
3
SOS1 [cytosol]
(R-HSA-64847)
SOS1 [plasma membrane]
(R-HSA-983559)
p-4S-SOS1 [cytosol]
(R-HSA-109821)
0.722
8
UniProt:P50570 DNM2
5
DNM2 [Golgi membrane]
(R-HSA-2980842)
DNM2 [endocytic vesicle membrane]
(R-HSA-2029000)
DNM2 [cytosol]
(R-HSA-2213180)
DNM2 [lysosomal membrane]
(R-HSA-2980840)
DNM2 [plasma membrane]
(R-HSA-2984201)
0.713
3
UniProt:O00401 WASL
4
p-Y256-WASL [cytosol]
(R-HSA-2197672)
N-WASP [cytosol]
(R-HSA-201873)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.704
5
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.643
5
UniProt:Q05193 DNM1
3
DNM1 [plasma membrane]
(R-HSA-177488)
DNM1 [lysosomal membrane]
(R-HSA-196150)
DNM1 [cytosol]
(R-HSA-2213182)
0.623
3
UniProt:O43426 SYNJ1
1
SYNJ1 [cytosol]
(R-HSA-1604634)
0.573
2
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.564
3
UniProt:Q3UQN2
1
Fcho2 [cytosol]
(R-MMU-8862260)
0.557
3
UniProt:Q9NRI5 DISC1
0.553
4
UniProt:Q9Y2W2 WBP11
1
WBP11 [nucleoplasm]
(R-HSA-8867887)
0.553
2
UniProt:P61968 LMO4
0.553
3
UniProt:Q12840 KIF5A
1
KIF5A [cytosol]
(R-HSA-983190)
0.553
2
UniProt:P60953-1 CDC42
0.544
2
UniProt:P53680 AP2S1
4
AP2S1 [endolysosome membrane]
(R-HSA-6784821)
AP2S1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130707)
AP2S1 [cytosol]
(R-HSA-182197)
AP2S1 [plasma membrane]
(R-HSA-389382)
0.527
3
UniProt:P60880 SNAP25
7
SNAP25(1-197) [plasma membrane]
(R-HSA-3004546)
SNAP25(198-206) [cytosol]
(R-HSA-5244499)
SNAP25(1-198) [plasma membrane]
(R-HSA-3004550)
SNAP25(199-206) [cytosol]
(R-HSA-5244501)
SNAP25 [tertiary granule membrane]
(R-HSA-6806142)
SNAP25 [specific granule membrane]
(R-HSA-6806154)
SNAP25 [plasma membrane]
(R-HSA-2029017)
0.502
2
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