Reactome | MAPKAP1 [cytosol]

MAPKAP1 [cytosol]

Stable Identifier

R-HSA-3006620

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Target of rapamycin complex 2 subunit MAPKAP1, SIN1_HUMAN, Stress-activated map kinase interacting protein 1

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - mTORC2 phosphorylates AKT1 on serine-473 (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        MAPKAP1 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Expression and Degradation (Homo sapiens)
        
        Regulation of TP53 Degradation (Homo sapiens)
        
        TORC2 complex phosphorylates SGK1 (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        MAPKAP1 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-stimulation by CD28 (Homo sapiens)
      - CD28 dependent PI3K/Akt signaling (Homo sapiens)
        
        TORC2 (mTOR) phosphorylates AKT at S473 (Homo sapiens)
        
        TORC2 complex [cytosol] (Homo sapiens)
        
        MAPKAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BPZ7 MAPKAP1

Gene Names

MAPKAP1, MIP1, SIN1

Chain

initiator methionine:, chain:2-522

Reference Genes

BioGPS Gene:79109 MAPKAP1

COSMIC (genes):MAPKAP1 MAPKAP1

CTD Gene:79109 MAPKAP1

dbSNP Gene:79109 MAPKAP1

ENSEMBL:ENSG00000119487 MAPKAP1

HGNC:18752 MAPKAP1

KEGG:hsa:79109 MAPKAP1

Monarch:79109 MAPKAP1

NCBI Gene:79109 MAPKAP1

OMIM:610558 MAPKAP1

UCSC:Q9BPZ7 MAPKAP1

Reference Transcript

Other Identifiers

11719296_a_at

11719297_s_at

11719298_x_at

11723575_x_at

11726890_a_at

11748111_a_at

11748112_x_at

11751490_a_at

11756830_x_at

17098424

1906_at

217808_PM_s_at

217808_s_at

222426_PM_at

222426_at

229845_PM_at

229845_at

229846_PM_s_at

229846_s_at

3225457

3225458

3225459

3225463

3225464

3225467

3225468

3225476

3225478

3225479

3225481

3225482

3225483

3225489

3225490

3225491

3225499

3225508

3225509

3225510

3225511

3225518

3225519

3225521

3225524

3225525

3225526

3225527

3225534

3225535

3225536

3225537

3225538

3225539

3225540

3225541

3225546

3225549

46231_at

59749_at

65919_at

76321_at

79109

8164177

A_23_P216894

A_24_P43884

A_33_P3251538

A_33_P3397755

GE82806

GE87196

GE87197

GO:0005515

GO:0005546

GO:0005547

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0007010

GO:0008289

GO:0019901

GO:0021762

GO:0030307

GO:0031267

GO:0031410

GO:0031669

GO:0031932

GO:0033138

GO:0038203

GO:0043066

GO:0043226

GO:0043325

GO:0046580

GO:0048856

GO:0060090

GO:0070300

GO:0080025

GO:1900407

HMNXSV003004216

HMNXSV003042668

Hs.324178.0.S2_3p_at

Hs.324178.1.S1_3p_at

ILMN_1691526

ILMN_2268068

ILMN_2360229

PH_hs_0016132

TC09002791.hg

g13129137_3p_a_at

p27774

Participates

as a component of

TORC2 complex [cytosol] (Homo sapiens)

Inferred To

sin1 [cytosol] (Schizosaccharomyces pombe)

sinh-1 [cytosol] (Caenorhabditis elegans)

ripA [cytosol] (Dictyostelium discoideum)

AVO1 [cytosol] (Saccharomyces cerevisiae)

MAPKAP1 [cytosol] (Canis familiaris)

MAPKAP1 [cytosol] (Gallus gallus)

MAPKAP1 [cytosol] (Mus musculus)

MAPKAP1 [cytosol] (Rattus norvegicus)

MAPKAP1 [cytosol] (Sus scrofa)

Sin1 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

XP_011517312.1, NP_001006622.1, XP_016870615.1, NP_001006620.1, NP_077022.1, NP_001006621.1, XP_016870616.1, NP_001006619.1, NP_001006618.1

OpenTargets

ENSG00000119487

ENSEMBL

ENST00000373503, ENSP00000377627, ENSP00000265960, ENSP00000265961, ENSG00000119487, ENST00000394063, ENST00000394060, ENSP00000377624, ENSP00000362602, ENST00000265960, ENSP00000362610, ENST00000350766, ENST00000373498, ENSP00000362597, ENST00000373511

HPA

ENSG00000119487-MAPKAP1

GeneCards

MAPKAP1

PRO

Q9BPZ7

Pharos - Targets

Q9BPZ7

GlyGen

Q9BPZ7

HMDB Protein

HMDBP02503

PDB

7PE9, 7LC2, 7PE8, 7VVG, 7LC1, 7VVB, 7PE7, 3VOQ, 7TZO, 6ZWO, 5ZCS, 7VV8, 7VV9, 6ZWM

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.643	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	2
UniProt:P78527 PRKDC	4	p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.499	2