Reactome | MAX [nucleoplasm]

MAX [nucleoplasm]

Stable Identifier

R-HSA-3006627

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Protein max, MAX_HUMAN

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by E2F6 (Homo sapiens)
      - CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
      - E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
        
        E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
      - E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
      - E2F6:TFDP1 binds to MGA:MAX (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
      - EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
        
        E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MGA:MAX [nucleoplasm] (Homo sapiens)
        
        MAX [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61244 MAX

Gene Names

MAX, BHLHD4

Chain

initiator methionine:1, chain:2-160, initiator methionine:1

Reference Genes

BioGPS Gene:4149 MAX

COSMIC (genes):MAX MAX

CTD Gene:4149 MAX

dbSNP Gene:4149 MAX

ENSEMBL:ENSG00000125952 MAX

HGNC:6913 MAX

KEGG:hsa:4149 MAX

Monarch:4149 MAX

NCBI Gene:4149 MAX

OMIM:154950 MAX

UCSC:P61244 MAX

Reference Transcript

Participates

as a component of

Inferred To

MAX [nucleoplasm] (Bos taurus)

MAX [nucleoplasm] (Canis familiaris)

MAX [nucleoplasm] (Gallus gallus)

MAX [nucleoplasm] (Sus scrofa)

Max [nucleoplasm] (Drosophila melanogaster)

Max [nucleoplasm] (Mus musculus)

Max [nucleoplasm] (Rattus norvegicus)

mxl-3 [nucleoplasm] (Caenorhabditis elegans)

max [nucleoplasm] (Danio rerio)

max [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001394024.1, NP_001394023.1, NP_932061.1, NP_660087.1, NP_001257997.1, NP_001394033.1, NP_001394032.1, NP_002373.3, NP_660089.1, NP_660088.1

OpenTargets

ENSG00000125952

ENSEMBL

ENSG00000125952, ENSP00000351490, ENSP00000246163, ENSP00000378104, ENST00000341653, ENST00000394606, ENSP00000351175, ENST00000556979, ENSP00000451907, ENSP00000342482, ENST00000553928, ENSP00000452378, ENST00000284165, ENST00000358402, ENST00000246163, ENSP00000284165, ENST00000358664

HPA

ENSG00000125952-MAX

GeneCards

MAX

ZINC - Substances

MAX_HUMAN

ZINC target

P61244

PRO

P61244

Pharos - Targets

P61244

Orphanet

MAX

PDB

1NKP, 6G6L, 6G6K, 8OTT, 1AN2, 8OTS, 1R05, 6G6J, 1NLW, 5EYO, 1HLO

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.982	50
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.847	9
UniProt:P04198 MYCN	1	MYCN [nucleoplasm] (R-HSA-452357)	0.844	10
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.773	7
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.708	6
UniProt:Q14582 MXD4	1	MXD4 [nucleoplasm] (R-HSA-9612293)	0.643	4
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.643	5
UniProt:Q8N9N5 BANP	2	BANP [cytosol] (R-HSA-9934681) BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.527	2
UniProt:Q9Y4A5 TRRAP	1	TRRAP [nucleoplasm] (R-HSA-3322951)	0.527	2
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.527	2
UniProt:Q96L91 EP400	1	EP400 [nucleoplasm] (R-HSA-3321987)	0.527	2
UniProt:O95619 YEATS4	1	YEATS4 [nucleoplasm] (R-HSA-3322940)	0.508	2
UniProt:P05549 TFAP2A	1	TFAP2A [nucleoplasm] (R-HSA-8864280)	0.499	2
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.499	2