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MAX [nucleoplasm]
Stable Identifier
R-HSA-3006627
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Protein max, MAX_HUMAN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G0 and Early G1 (Homo sapiens)
Transcription of E2F targets under negative control by DREAM complex (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
MYC:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
MYC:MAX:CDC25A gene [nucleoplasm] (Homo sapiens)
MYC:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
MYC:MAX binds the CDC25A gene (Homo sapiens)
MYC:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
MYC:MAX:CDC25A gene [nucleoplasm] (Homo sapiens)
MYC:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
MYC:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
MYC:MAX:CDC25A gene [nucleoplasm] (Homo sapiens)
MYC:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex (Homo sapiens)
MYC:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
MYC:MAX:CDC25A gene [nucleoplasm] (Homo sapiens)
MYC:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
MGA:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
MGA:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
MGA:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
MGA:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
MGA:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
MGA:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
E2F6:TFDP1 binds to MGA:MAX (Homo sapiens)
E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
MGA:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
MGA:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)
E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
MGA:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX [nucleoplasm] (Homo sapiens)
MGA:MAX [nucleoplasm] (Homo sapiens)
MAX [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61244 MAX
Gene Names
MAX, BHLHD4
Chain
initiator methionine:, chain:2-160, initiator methionine:
Reference Genes
COSMIC (genes):MAX MAX
dbSNP Gene:4149 MAX
ENSEMBL:ENSG00000125952 MAX
Participates
as a component of
MGA:MAX [nucleoplasm] (Homo sapiens)
MYC:MAX [nucleoplasm] (Homo sapiens)
Inferred To
MAX [nucleoplasm]
(Bos taurus)
MAX [nucleoplasm]
(Canis familiaris)
MAX [nucleoplasm]
(Gallus gallus)
MAX [nucleoplasm]
(Sus scrofa)
Max [nucleoplasm]
(Drosophila melanogaster)
Max [nucleoplasm]
(Mus musculus)
Max [nucleoplasm]
(Rattus norvegicus)
mxl-3 [nucleoplasm]
(Caenorhabditis elegans)
max [nucleoplasm]
(Danio rerio)
max [nucleoplasm]
(Xenopus tropicalis)
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.982
50
UniProt:P04198 MYCN
1
MYCN [nucleoplasm]
(R-HSA-452357)
0.844
10
UniProt:Q969R5 L3MBTL2
2
L3MBTL2 [nucleoplasm]
(R-HSA-6804477)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(R-HSA-6804480)
0.803
8
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.773
7
UniProt:O75461 E2F6
2
E2F6 [nucleoplasm]
(R-HSA-8953089)
p-S12-E2F6 [nucleoplasm]
(R-HSA-9007536)
0.708
6
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.643
5
UniProt:Q14582 MXD4
1
MXD4 [nucleoplasm]
(R-HSA-9612293)
0.643
4
UniProt:Q8N9N5 BANP
1
BANP [nucleoplasm]
(R-HSA-3221973)
0.556
3
UniProt:Q9Y4A5 TRRAP
1
TRRAP [nucleoplasm]
(R-HSA-3322951)
0.527
2
UniProt:Q96ST3 SIN3A
2
SIN3A [nucleoplasm]
(R-HSA-351657)
monoSUMO1-SIN3A [nucleoplasm]
(R-HSA-4086071)
0.527
2
UniProt:Q96L91 EP400
1
EP400 [nucleoplasm]
(R-HSA-3321987)
0.527
2
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.527
2
UniProt:O95619 YEATS4
1
YEATS4 [nucleoplasm]
(R-HSA-3322940)
0.508
2
UniProt:P05549 TFAP2A
1
TFAP2A [nucleoplasm]
(R-HSA-8864280)
0.499
2
UniProt:P29692 EEF1D
1
EEF1D [cytosol]
(R-HSA-156914)
0.499
2
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