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MCF2 [cytosol]
Stable Identifier
R-HSA-3006639
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Proto-oncogene DBL, MCF2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
MCF2 [cytosol] (Homo sapiens)
p75NTR regulates axonogenesis (Homo sapiens)
Axonal growth inhibition (RHOA activation) (Homo sapiens)
RhoA is activated by nucleotide exchange and inhibits axonal growth (Homo sapiens)
MCF2 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
MCF2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
MCF2 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
MCF2 [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 GEFs activate RAC2 (Homo sapiens)
RAC2 GEFs [cytosol] (Homo sapiens)
MCF2 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 GEFs activate RAC3 (Homo sapiens)
RAC3 GEFs [cytosol] (Homo sapiens)
MCF2 [cytosol] (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA GEFs activate RHOA (Homo sapiens)
RHOA GEFs [cytosol] (Homo sapiens)
MCF2 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB GEFs activate RHOB (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
MCF2 [cytosol] (Homo sapiens)
RHOC GTPase cycle (Homo sapiens)
RHOC GEFs activate RHOC (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
MCF2 [cytosol] (Homo sapiens)
RHOG GTPase cycle (Homo sapiens)
RHOG GEFs activate RHOG (Homo sapiens)
RHOG GEFs [cytosol] (Homo sapiens)
MCF2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10911 MCF2
Gene Names
MCF2, DBL
Chain
chain:1-925, chain:398-925, chain:498-925
Reference Genes
BioGPS Gene:4168 MCF2
COSMIC (genes):MCF2 MCF2
CTD Gene:4168 MCF2
dbSNP Gene:4168 MCF2
ENSEMBL:ENSG00000101977 MCF2
HGNC:6940 MCF2
KEGG:hsa:4168 MCF2
Monarch:4168 MCF2
NCBI Gene:4168 MCF2
OMIM:311030 MCF2
UCSC:P10911 MCF2
Reference Transcript
RefSeq:NM_001171876.1 MCF2
RefSeq:NM_001171877.1 MCF2
RefSeq:NM_001171878.1 MCF2
RefSeq:NM_001171879.1 MCF2
RefSeq:XM_011531339.2 MCF2
RefSeq:NM_005369.4 MCF2
RefSeq:XM_017029531.1 MCF2
RefSeq:NM_001099855.1 MCF2
Other Identifiers
11733434_a_at
11733435_x_at
11747021_x_at
11749471_a_at
11754152_a_at
1555313_PM_a_at
1555313_a_at
17114606
1806_at
1807_g_at
208017_PM_s_at
208017_s_at
217004_PM_s_at
217004_s_at
4024096
4024097
4024098
4024099
4024100
4024101
4024103
4024104
4024105
4024106
4024107
4024108
4024109
4024110
4024111
4024112
4024113
4024114
4024115
4024118
4024119
4024120
4024121
4024123
4024124
4024125
4024126
4024127
4024128
4024129
4024130
4024131
4024132
4024133
4024134
4024135
4024137
4024138
4024139
4024146
4024147
4024148
4024149
4168
8175457
GE56450
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005856
GO:0016020
GO:0016358
GO:0019898
GO:0035556
GO:0043226
GO:0048856
GO:0050771
GO:0051056
GO:0098772
GO:1990830
HMNXSV003023716
Hs.89543.3.S1_3p_a_at
Hs2.89543.3.S1_3p_s_at
ILMN_1752750
PH_hs_0024419
TC0X001427.hg
X12556_at
g4885478_3p_a_at
Participates
as a member of
RHOA GEFs [cytosol] (Homo sapiens)
RHOC GEFs [cytosol] (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
RAC2 GEFs [cytosol] (Homo sapiens)
RHOB GEFs [cytosol] (Homo sapiens)
RHOG GEFs [cytosol] (Homo sapiens)
RAC3 GEFs [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
as a candidate of
RAC1 GEFs [cytosol] (Homo sapiens)
Inferred To
cgef-1 [cytosol]
(Caenorhabditis elegans)
MCF2 [cytosol]
(Bos taurus)
MCF2 [cytosol]
(Canis familiaris)
MCF2 [cytosol]
(Gallus gallus)
MCF2 [cytosol]
(Sus scrofa)
CG12183 [cytosol]
(Drosophila melanogaster)
Mcf2 [cytosol]
(Mus musculus)
Mcf2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
XP_011529641.1
,
XP_016885020.1
,
NP_001165348.1
,
NP_001165350.1
,
NP_001165347.1
,
NP_001165349.1
,
NP_005360.3
,
NP_001093325.1
OpenTargets
ENSG00000101977
ENSEMBL
ENST00000414978
,
ENSP00000359608
,
ENSP00000359605
,
ENST00000370576
,
ENST00000536274
,
ENST00000338585
,
ENSP00000342204
,
ENST00000370573
,
ENSP00000430276
,
ENSP00000397055
,
ENST00000519895
,
ENSP00000438155
HPA
ENSG00000101977-MCF2
PRO
P10911
Pharos - Targets
P10911
HMDB Protein
HMDBP01783
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35241 RDX
2
p-T564-RDX [cytosol]
(R-HSA-9662922)
RDX [cytosol]
(R-HSA-437348)
0.544
2
UniProt:P15531 NME1
1
NME1 [cytosol]
(R-HSA-60022)
0.532
4
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